1,4-3,6-dianhydromannitol profile

1,4:3,6-dianhydromannitol (DAM) is a cyclic ether derived from the sugar mannitol. It's a white, crystalline solid that's soluble in water and organic solvents.

Here's why DAM is important in research:

**1. Applications in Polymer Science:**

* **Crosslinking Agent:** DAM is used as a crosslinking agent for polymers, particularly for creating thermoset resins. It forms strong bonds between polymer chains, enhancing the material's strength, stiffness, and thermal stability. This is particularly useful in the development of high-performance plastics and resins used in various industries.

**2. Biomedical Applications:**

* **Drug Delivery:** DAM can be modified to create drug delivery systems. Its structure allows it to be conjugated with various drugs, leading to targeted drug delivery and controlled release. This is particularly important in areas like cancer therapy and gene delivery.

**3. Material Science:**

* **Nanomaterials:** DAM has been investigated for its role in the synthesis of nanomaterials. It can act as a template or building block for the fabrication of nanostructured materials with unique properties. This area has potential in electronics, catalysis, and energy storage.

**4. Analytical Chemistry:**

* **Chiral Analysis:** DAM derivatives can be used as chiral selectors in chromatography. This helps in separating and analyzing enantiomers, which are mirror-image molecules with different biological activities.

**5. Other Applications:**

* **Antiviral Agent:** Research suggests that DAM might have antiviral activity against certain viruses.
* **Antibacterial Agent:** Some studies indicate potential antibacterial properties of DAM, although further research is needed.

**Overall, DAM's unique chemical structure and properties make it a valuable molecule in various research fields. Its applications continue to be explored, with promising potential for advancements in materials science, drug delivery, and other areas.**

1,4-3,6-dianhydromannitol: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	99937
SCHEMBL ID	244589
MeSH ID	M0487169

Synonym
AKOS009031419
einecs 248-906-7
mannitol, 1,4:3,6-dianhydro-
nsc270938
nsc-270938
d-mannitol,4:3,6-dianhydro-
OPREA1_439690
nsc-231906
nsc231906
2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3,6-diol
A834663
einecs 211-374-1
nsc 270938
1,4-3,6-dianhydromannitol
28218-68-0
FT-0606757
FT-0627423
SCHEMBL244589
hexahydro-furo[3,2-b]furan-3,6-diol
hexahydrofuro[3,2-b]furan-3,6-diol
SY003633
28948-16-5
d-sorbitol, 1,4:3,6-dianhydro
CS-0077330
d-isosorbide; dianhydro-d-glucitol;dianhydrosorbitol
BCP13451
CS-11040
SY263338
mfcd32202826
89825-36-5
(s)-3-ethyl-6-[(benzylamino)methyl]-1,3-oxazinan-2-one
mannitol,1,4:3,6-dianhydro-
EN300-20516
DTXSID801031676
d-iditol, 1,4:3,6-dianhydro-

Excerpt	Relevance	Reference
" NCX 667 or vehicle (30 µL) was instilled in a crossover, masked fashion and intraocular pressure (IOP) measured before dosing (baseline) and for several hours thereafter."	( NCX 667, a Novel Nitric Oxide Donor, Lowers Intraocular Pressure in Rabbits, Dogs, and Non-Human Primates and Enhances TGFβ2-Induced Outflow in HTM/HSC Constructs. Ahmed, F; Almirante, N; Bastia, E; Bergamini, MVW; Brambilla, S; Galli, C; Impagnatiello, F; Masini, E; Navratil, T; Sgambellone, S; Toris, CB; Torrejon, KY; Unser, AM, 2021)	0.62

Assay ID	Title	Year	Journal	Article
AID1794808	Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).	2014	Journal of biomolecular screening, Jul, Volume: 19, Issue:6	A High-Throughput Assay to Identify Inhibitors of the Apicoplast DNA Polymerase from Plasmodium falciparum.
AID1794808	Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	3 (18.75)	18.7374
1990's	0 (0.00)	18.2507
2000's	2 (12.50)	29.6817
2010's	7 (43.75)	24.3611
2020's	4 (25.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	16 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
carbamates [no description available]	2.41	1	amino-acid anion
carbon monoxide Carbon Monoxide: Carbon monoxide (CO). A poisonous colorless, odorless, tasteless gas. It combines with hemoglobin to form carboxyhemoglobin, which has no oxygen carrying capacity. The resultant oxygen deprivation causes headache, dizziness, decreased pulse and respiratory rates, unconsciousness, and death. (From Merck Index, 11th ed). carbon monoxide : A one-carbon compound in which the carbon is joined only to a single oxygen. It is a colourless, odourless, tasteless, toxic gas.	2.1	1	carbon oxide; gas molecular entity; one-carbon compound	biomarker; EC 1.9.3.1 (cytochrome c oxidase) inhibitor; human metabolite; ligand; metabolite; mitochondrial respiratory-chain inhibitor; mouse metabolite; neurotoxin; neurotransmitter; P450 inhibitor; probe; signalling molecule; vasodilator agent
sorbitol [no description available]	2.61	3	hexitol
mannitol [no description available]	2.35	2	mannitol	allergen; antiglaucoma drug; compatible osmolytes; Escherichia coli metabolite; food anticaking agent; food bulking agent; food humectant; food stabiliser; food thickening agent; hapten; metabolite; osmotic diuretic; sweetening agent
1-octene 1-octene: RN given refers to parent cpd. 1-octene : An octene with an unsaturation C-1.	2.1	1	octene
oxazoles Oxazoles: Five-membered heterocyclic ring structures containing an oxygen in the 1-position and a nitrogen in the 3-position, in distinction from ISOXAZOLES where they are at the 1,2 positions.. 1,3-oxazole : A five-membered monocyclic heteroarene that is an analogue of cyclopentadiene with O in place of CH2 at position 1 and N in place of CH at position 3.. oxazole : An azole based on a five-membered heterocyclic aromatic skeleton containing one N and one O atom.	2.05	1	1,3-oxazoles; mancude organic heteromonocyclic parent; monocyclic heteroarene
isosorbide Isosorbide: 1,4:3,6-Dianhydro D-glucitol. Chemically inert osmotic diuretic used mainly to treat hydrocephalus; also used in glaucoma.	2.91	4	organic molecular entity
mannose mannopyranose : The pyranose form of mannose.	2.02	1	D-aldohexose; D-mannose; mannopyranose	metabolite
palladium Palladium: A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.. palladium : Chemical element (nickel group element atom) with atomic number 46.	2.1	1	metal allergen; nickel group element atom; platinum group metal atom
iodine [no description available]	2.1	1	halide anion; monoatomic iodine	human metabolite
alkenes [no description available]	2.1	1
iditol iditol: RN refers to L-isomer. L-iditol : The L-enantiomer of iditol.	1.92	1	iditol	fungal metabolite; human metabolite
cyclic gmp Cyclic GMP: Guanosine cyclic 3',5'-(hydrogen phosphate). A guanine nucleotide containing one phosphate group which is esterified to the sugar moiety in both the 3'- and 5'-positions. It is a cellular regulatory agent and has been described as a second messenger. Its levels increase in response to a variety of hormones, including acetylcholine, insulin, and oxytocin and it has been found to activate specific protein kinases. (From Merck Index, 11th ed). 3',5'-cyclic GMP : A 3',5'-cyclic purine nucleotide in which the purine nucleobase is specified as guanidine.	2.31	1	3',5'-cyclic purine nucleotide; guanyl ribonucleotide	Escherichia coli metabolite; human metabolite; mouse metabolite; plant metabolite; Saccharomyces cerevisiae metabolite

Condition	Relationship Strength	Studies
Plasmodium falciparum Malaria [description not available]	2.1	1
Malaria, Falciparum Malaria caused by PLASMODIUM FALCIPARUM. This is the severest form of malaria and is associated with the highest levels of parasites in the blood. This disease is characterized by irregularly recurring febrile paroxysms that in extreme cases occur with acute cerebral, renal, or gastrointestinal manifestations.	2.1	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.31	1
Glaucoma, Suspect [description not available]	2.31	1
Intraocular Pressure The pressure of the fluids in the eye.	2.31	1
Ocular Hypertension A condition in which the intraocular pressure is elevated above normal and which may lead to glaucoma.	2.31	1
Flaviviridae Infections Infections with viruses of the family FLAVIVIRIDAE.	2.02	1

1,4-3,6-dianhydromannitol

Description

Cross-References

Synonyms (35)

Research Excerpts

Dosage Studied

Bioassays (2)

Research

Studies (16)

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Research Demand Index: 11.91

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