Page last updated: 2024-12-07

1-(1-naphthyl)ethylamine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

1-(1-naphthyl)ethylamine, also known as **1-NPEA**, is a naturally occurring compound found in plants, specifically in the **leaves and stems of the khat plant (Catha edulis)**. It's a **monoamine alkaloid** with a structure similar to amphetamine.

Here's why it's important for research:

**1. Pharmacological Effects:**

* **Stimulant:** 1-NPEA possesses stimulant properties, similar to amphetamine, but weaker. It can increase alertness, energy levels, and mood.
* **Possible antidepressant potential:** Some studies suggest 1-NPEA might have antidepressant-like effects, potentially by influencing the serotonin system.
* **Effects on the central nervous system:** 1-NPEA acts as a neurotransmitter and affects various brain regions, including the hypothalamus, the amygdala, and the hippocampus. This makes it a potential target for research on mood disorders, anxiety, and other neurological conditions.

**2. Role in Khat Use:**

* **Main psychoactive component:** 1-NPEA is one of the main psychoactive components of the khat plant, contributing to its stimulating and mood-altering effects.
* **Understanding khat's effects:** Studying 1-NPEA helps researchers understand the mechanisms behind khat use and its potential risks and benefits.

**3. Potential Therapeutic Applications:**

* **Antidepressant development:** Due to its potential antidepressant effects, 1-NPEA is being investigated as a possible lead compound for developing new antidepressant medications.
* **Treating other neurological disorders:** Its effects on the central nervous system suggest possible therapeutic applications in treating other neurological conditions like ADHD, anxiety, and cognitive impairment.

**4. Research Challenges:**

* **Limited availability:** 1-NPEA is a naturally occurring compound with limited availability, making it challenging to study.
* **Ethical considerations:** Research involving khat and its derivatives requires careful ethical considerations due to its potential for abuse and addiction.

**Overall, 1-NPEA is a fascinating compound with potential for both scientific understanding and therapeutic development. Research into its pharmacological effects and its role in khat use is ongoing, with potential implications for various fields, including medicine, pharmacology, and neurobiology.**

Cross-References

ID SourceID
PubMed CID98089
CHEMBL ID217783
SCHEMBL ID1906169
SCHEMBL ID128713
SCHEMBL ID21538667
MeSH IDM0156102

Synonyms (69)

Synonym
3309-13-5
nsc-180601
nsc180601
(+/-)1-(1-naphthyl)ethylamine
nsc75881
42882-31-5
nsc-75881
nsc75882
1-naphthalenemethanamine, (.+-.)-
nsc-75882
1-(1-naphthyl)ethylamine, 98%
STK486972
1-(naphthalen-1-yl)ethanamine
CHEMBL217783
1-naphthalen-1-ylethanamine
FT-0690506
dl-alpha-(1-aminoethyl)naphthalene
N0523
dl-1-(1-naphthyl)ethylamine
AKOS000121452
BBL017842
SCHEMBL1906169
A826048
cyclopropylmethyl cyclobutanecarboxylate;1-(1-naphthyl)ethylamine
nsc 75881
nsc 180601
1-naphthalenemethanamine, alpha-methyl-
1-(1-naphthyl)ethylamine
1-naphthalenemethanamine, alpha-methyl-, (alphar)-
einecs 223-425-5
1-naphthalenemethanamine, alpha-methyl-, (r)-(+)-
r-(+)-1-(1-naphthyl)ethylamine
(r)-alpha-methyl-1-naphthalenemethanamine
ai3-26857
FT-0604442
FT-0605082
FT-0601942
1-naphthalenemethanamine, .alpha.-methyl-, (.alpha.s)-
(+/-)-1-(1-naphthyl)ethylamine
1-naphthalenemethanamine, .alpha.-methyl-
CS-M0087
1-(1-naphthyl)ethanamine
alpha-naphthylethylamine
dl-1-(1-naphthyl)-ethyl amine
1-(1-napthyl)ethylamine
1-(naphth-1-yl)ethylamine
(+/-)-1-(1-naphthyl)ethanamine
alpha-naphthyl ethyl amine
SCHEMBL128713
AKOS016050384
SY004251
1-naphthalenemethanamine, .alpha.-methyl-, (.alpha.r)-
J-500066
SY020862
1-naphthalenemethanamine, .alpha.-methyl-, (.+/-.)-
.+/-.-1-(1-naphthyl)ethylamine
mfcd00004014
1-(naphthalen-1-yl)ethan-1-amine
SY032143
FT-0672644
BCP19747
DS-14626
SCHEMBL21538667
AMY31218
SB36972
DTXSID40885878
STARBLD0002964
PB48766
EN300-21182
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (2)

Assay IDTitleYearJournalArticle
AID273097Activity of human SSAO measured as hydrogen peroxide production at 1 mM relative to benzylamine oxidation2006Journal of medicinal chemistry, Oct-19, Volume: 49, Issue:21
New efficient substrates for semicarbazide-sensitive amine oxidase/VAP-1 enzyme: analysis by SARs and computational docking.
AID273098Activity of mouse SSAO measured as hydrogen peroxide production at 100 uM relative to benzylamine oxidation2006Journal of medicinal chemistry, Oct-19, Volume: 49, Issue:21
New efficient substrates for semicarbazide-sensitive amine oxidase/VAP-1 enzyme: analysis by SARs and computational docking.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (12)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (8.33)18.7374
1990's3 (25.00)18.2507
2000's3 (25.00)29.6817
2010's4 (33.33)24.3611
2020's1 (8.33)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 33.23

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index33.23 (24.57)
Research Supply Index2.56 (2.92)
Research Growth Index4.92 (4.65)
Search Engine Demand Index31.59 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (33.23)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other12 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]