60S ribosomal protein L27a

A eukaryotic-type large ribosomal subunit protein uL15 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P46776]

Large ribosomal subunit protein uL15

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
gentamicin sulfate	Homo sapiens (human)	IC50	26.0000	1	1
PF-06446846	Homo sapiens (human)	IC50	2.1250	4	4

This protein enables 3 target(s):

Target	Category	Definition
RNA binding	molecular function	Binding to an RNA molecule or a portion thereof. [GOC:jl, GOC:mah]
structural constituent of ribosome	molecular function	The action of a molecule that contributes to the structural integrity of the ribosome. [GOC:mah]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]

This protein is located in 6 target(s):

Target	Category	Definition
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
endoplasmic reticulum	cellular component	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
cytosolic ribosome	cellular component	A ribosome located in the cytosol. [GOC:mtg_sensu]

This protein is part of 1 target(s):

Target	Category	Definition
cytosolic large ribosomal subunit	cellular component	The large subunit of a ribosome located in the cytosol. [GOC:mtg_sensu]

This protein is involved in 2 target(s):

Target	Category	Definition
cytoplasmic translation	biological process	The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein. [GOC:hjd]
translation	biological process	The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. [GOC:go_curators]