Page last updated: 2024-08-07 18:30:59
60S ribosomal protein L35a
A large ribosomal subunit protein eL33 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P18077]
Synonyms
Cell growth-inhibiting gene 33 protein;
Large ribosomal subunit protein eL33
Research
Bioassay Publications (3)
Timeframe | Studies on this Protein(%) | All Drugs % |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 3 (100.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Compounds (2)
Drugs with Inhibition Measurements
Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
---|---|---|---|---|---|
gentamicin sulfate | Homo sapiens (human) | IC50 | 26.0000 | 1 | 1 |
PF-06446846 | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
Enables
This protein enables 4 target(s):
Target | Category | Definition |
---|---|---|
tRNA binding | molecular function | Binding to a transfer RNA. [GOC:ai] |
RNA binding | molecular function | Binding to an RNA molecule or a portion thereof. [GOC:jl, GOC:mah] |
structural constituent of ribosome | molecular function | The action of a molecule that contributes to the structural integrity of the ribosome. [GOC:mah] |
protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
Located In
This protein is located in 5 target(s):
Target | Category | Definition |
---|---|---|
cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
membrane | cellular component | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] |
extracellular exosome | cellular component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |
cytosolic ribosome | cellular component | A ribosome located in the cytosol. [GOC:mtg_sensu] |
Part Of
This protein is part of 1 target(s):
Target | Category | Definition |
---|---|---|
cytosolic large ribosomal subunit | cellular component | The large subunit of a ribosome located in the cytosol. [GOC:mtg_sensu] |
Involved In
This protein is involved in 4 target(s):
Target | Category | Definition |
---|---|---|
cytoplasmic translation | biological process | The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein. [GOC:hjd] |
rRNA processing | biological process | Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. [GOC:curators] |
translation | biological process | The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. [GOC:go_curators] |
ribosomal large subunit biogenesis | biological process | A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis. [GOC:jl] |