60S acidic ribosomal protein P1

A large ribosomal subunit protein P1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P05386]

Large ribosomal subunit protein P1

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
gentamicin sulfate	Homo sapiens (human)	IC50	26.0000	1	1
PF-06446846	Homo sapiens (human)	IC50	2.1250	4	4

This protein enables 4 target(s):

Target	Category	Definition
structural constituent of ribosome	molecular function	The action of a molecule that contributes to the structural integrity of the ribosome. [GOC:mah]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
ribonucleoprotein complex binding	molecular function	Binding to a complex of RNA and protein. [GOC:bf, GOC:go_curators, GOC:vk]
protein kinase activator activity	molecular function	Binds to and increases the activity of a protein kinase, an enzyme which phosphorylates a protein. [GOC:ai]

This protein is located in 4 target(s):

Target	Category	Definition
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
focal adhesion	cellular component	A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ). [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002]
cytosolic ribosome	cellular component	A ribosome located in the cytosol. [GOC:mtg_sensu]

This protein is part of 1 target(s):

Target	Category	Definition
cytosolic large ribosomal subunit	cellular component	The large subunit of a ribosome located in the cytosol. [GOC:mtg_sensu]

This protein is involved in 3 target(s):

Target	Category	Definition
cytoplasmic translation	biological process	The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein. [GOC:hjd]
translation	biological process	The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. [GOC:go_curators]
translational elongation	biological process	The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. [GOC:ems]