A eukaryotic-type large ribosomal subunit protein uL5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P62913]
CLL-associated antigen KW-12;
Large ribosomal subunit protein uL5
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| gentamicin sulfate | Homo sapiens (human) | IC50 | 26.0000 | 1 | 1 |
| PF-06446846 | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
This protein enables 6 target(s):
| Target | Category | Definition |
|---|---|---|
| RNA binding | molecular function | Binding to an RNA molecule or a portion thereof. [GOC:jl, GOC:mah] |
| structural constituent of ribosome | molecular function | The action of a molecule that contributes to the structural integrity of the ribosome. [GOC:mah] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| 5S rRNA binding | molecular function | Binding to a 5S ribosomal RNA, the smallest RNA constituent of a ribosome. [GOC:jl, ISBN:0321000382] |
| ubiquitin protein ligase binding | molecular function | Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins. [GOC:vp] |
| ubiquitin ligase inhibitor activity | molecular function | Binds to and stops, prevents or reduces the activity of a ubiquitin ligase. [GOC:dph, GOC:vw, PMID:21389117] |
This protein is located in 7 target(s):
| Target | Category | Definition |
|---|---|---|
| nucleoplasm | cellular component | That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653] |
| nucleolus | cellular component | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. [ISBN:0198506732] |
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| membrane | cellular component | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] |
| extracellular exosome | cellular component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |
| cytosolic ribosome | cellular component | A ribosome located in the cytosol. [GOC:mtg_sensu] |
This protein is part of 2 target(s):
| Target | Category | Definition |
|---|---|---|
| cytosolic large ribosomal subunit | cellular component | The large subunit of a ribosome located in the cytosol. [GOC:mtg_sensu] |
| protein-containing complex | cellular component | A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. [GOC:dos, GOC:mah] |
This protein is involved in 16 target(s):
| Target | Category | Definition |
|---|---|---|
| ribosomal large subunit assembly | biological process | The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit. [GOC:jl, PMID:30467428] |
| cytoplasmic translation | biological process | The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein. [GOC:hjd] |
| rRNA processing | biological process | Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. [GOC:curators] |
| translation | biological process | The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. [GOC:go_curators] |
| protein targeting | biological process | The process of targeting specific proteins to particular regions of the cell, typically membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif. [GOC:ma] |
| positive regulation of gene expression | biological process | Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). [GOC:txnOH-2018] |
| positive regulation of protein binding | biological process | Any process that activates or increases the frequency, rate or extent of protein binding. [GOC:mah] |
| negative regulation of proteasomal ubiquitin-dependent protein catabolic process | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. [GOC:mah] |
| protein localization to nucleus | biological process | A process in which a protein transports or maintains the localization of another protein to the nucleus. [GOC:ecd] |
| ribosomal large subunit biogenesis | biological process | A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis. [GOC:jl] |
| protein stabilization | biological process | Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation. [GOC:ai] |
| regulation of signal transduction by p53 class mediator | biological process | Any process that modulates the frequency, rate or extent of signal transduction by p53 class mediator. [GOC:TermGenie] |
| positive regulation of signal transduction by p53 class mediator | biological process | Any process that activates or increases the frequency, rate or extent of signal transduction by p53 class mediator. [GOC:TermGenie] |
| negative regulation of ubiquitin protein ligase activity | biological process | Any process that stops, prevents or reduces the frequency, rate or extent of ubiquitin protein ligase activity. [GO_REF:0000059, GOC:dph, GOC:tb, GOC:TermGenie, PMID:26216882] |
| negative regulation of ubiquitin-dependent protein catabolic process | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of ubiquitin-dependent protein catabolic process. [GOC:BHF] |
| negative regulation of protein neddylation | biological process | Any process that stops, prevents or reduces the frequency, rate or extent of protein neddylation. [GOC:obol] |