Compounds > e 5110
Page last updated: 2024-09-03

e 5110 and indomethacin

e 5110 has been researched along with indomethacin in 4 studies

Compound Research Comparison

Studies
(e 5110)		Trials
(e 5110)		Recent Studies (post-2010)
(e 5110)		Studies
(indomethacin)		Trials
(indomethacin)		Recent Studies (post-2010) (indomethacin)
120029,5271,8383,396

Protein Interaction Comparison

ProteinTaxonomye 5110 (IC50)indomethacin (IC50)
Chain A, membrane-associated prostaglandin E synthase-2Macaca fascicularis (crab-eating macaque)1000
Prostaglandin-H2 D-isomeraseMus musculus (house mouse)1.1
Multidrug resistance-associated protein 4Homo sapiens (human)5.8
Prostaglandin G/H synthase 1 Bos taurus (cattle)0.9994
Prostaglandin G/H synthase 2 Bos taurus (cattle)0.7764
Cytochrome c oxidase subunit 2Homo sapiens (human)0.34
Prostaglandin G/H synthase 1Ovis aries (sheep)0.5605
Neuronal acetylcholine receptor subunit alpha-4Rattus norvegicus (Norway rat)0.004
Interleukin-8Homo sapiens (human)0.05
Neuronal acetylcholine receptor subunit beta-2Rattus norvegicus (Norway rat)0.004
Aldo-keto reductase family 1 member B1Homo sapiens (human)6
Aldo-keto reductase family 1 member B1Bos taurus (cattle)5
Prostaglandin G/H synthase 1Mus musculus (house mouse)0.011
Prostaglandin G/H synthase 1Homo sapiens (human)0.4848
Sodium- and chloride-dependent GABA transporter 1Rattus norvegicus (Norway rat)0.2
Thromboxane-A synthase Homo sapiens (human)0.1
Indoleamine 2,3-dioxygenase 1Mus musculus (house mouse)0.082
Nitric oxide synthase, inducibleMus musculus (house mouse)4.5
Substance-P receptorCavia porcellus (domestic guinea pig)5.7
Sodium- and chloride-dependent GABA transporter 2Rattus norvegicus (Norway rat)0.2
Sodium- and chloride-dependent GABA transporter 3Rattus norvegicus (Norway rat)0.2
Prostaglandin G/H synthase 2Homo sapiens (human)1.5128
Prostaglandin G/H synthase 2 Rattus norvegicus (Norway rat)0.5504
Aldo-keto reductase family 1 member C3Homo sapiens (human)3.4486
Sodium- and chloride-dependent betaine transporterRattus norvegicus (Norway rat)0.2
C-X-C chemokine receptor type 3Homo sapiens (human)0.05
Aldo-keto reductase family 1 member C2 Homo sapiens (human)8.97
Prostaglandin G/H synthase 2Ovis aries (sheep)3.4647
Prostaglandin G/H synthase 2Mus musculus (house mouse)0.4233
Solute carrier family 22 member 6Homo sapiens (human)3
Sigma intracellular receptor 2Rattus norvegicus (Norway rat)0.49
Rho-associated protein kinase 2Rattus norvegicus (Norway rat)7.7
Prostaglandin G/H synthase 1 Rattus norvegicus (Norway rat)0.5461
P2Y purinoceptor 12Rattus norvegicus (Norway rat)0.96

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19904 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ikuta, H; Katayama, K; Kobayashi, S; Shirota, H; Yamada, K; Yamagishi, Y; Yamatsu, I1
Ikuta, H; Katayama, K; Kobayashi, S; Sakuma, Y; Shirota, H; Terato, K; Yamada, K; Yamagishi, Y; Yamatsu, I1
Chiba, K; Ikuta, H; Katayama, K; Kobayashi, S; Ono, H; Shirota, H; Terato, K; Yamamoto, H; Yamatsu, I1
Chiba, K; Ikuta, H; Katayama, K; Kobayashi, S; Ono, H; Shirota, H; Terato, K; Yamatsu, I1

Other Studies

4 other study(ies) available for e 5110 and indomethacin

ArticleYear
Synthesis and antiinflammatory activities of 3-(3,5-di-tert-butyl-4-hydroxybenzylidene)pyrrolidin-2-ones.
    Journal of medicinal chemistry, 1987, Volume: 30, Issue:11

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzylidene Compounds; Cyclooxygenase Inhibitors; Dinoprostone; Humans; Male; Prostaglandins E; Pyrrolidinones; Rats; Rats, Inbred Strains; Stomach Ulcer

1987
Effect of the novel non-steroidal antiinflammatory agent N-methoxy-3-(3,5-di-tert-butyl-4-hydroxybenzylidene)pyrrolidin-2-one on in vitro generation of some inflammatory mediators.
    Arzneimittel-Forschung, 1987, Volume: 37, Issue:8

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dinoprostone; Humans; Indomethacin; Inflammation; Interleukin-1; Leukocytes; Leukotriene B4; Piroxicam; Prostaglandins E; Pyrogens; Pyrrolidinones; Rats; Superoxides

1987
Pharmacological properties of the novel non-steroidal antiinflammatory agent N-methoxy-3-(3,5-di-tert-butyl-4-hydroxybenzylidene)pyrrolidin-2 -one.
    Arzneimittel-Forschung, 1987, Volume: 37, Issue:8

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Body Temperature; Capillary Permeability; Indomethacin; Mice; Piroxicam; Pyrrolidinones; Rats

1987
Pharmacological properties of N-methoxy-3-(3,5-ditert-butyl-4-hydroxybenzylidene)-2-pyrrolidone (E-5110), a novel nonsteroidal antiinflammatory agent.
    Agents and actions, 1987, Volume: 21, Issue:3-4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Fever; Indomethacin; Inflammation; Pain; Piroxicam; Pyrrolidinones; Rats; Stomach Ulcer

1987
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