viscolin has been researched along with Edema* in 1 studies
1 other study(ies) available for viscolin and Edema
| Article | Year |
|---|---|
A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions.
In the present report, a concise synthesis of viscolin (1) has been achieved. The anti-inflammatory effect of viscolin was investigated in vitro and in vivo. Viscolin blocked the expression of iNOS and COX-2, and it also inhibited the ERK for the activation of NF-κB in LPS-stimulated RAW 264.7 macrophages. Western blotting and immunohistochemical analysis revealed that viscolin decreased Carr-induced iNOS and COX-2 expressions. These results could help to deduce the anti-inflammatory mechanisms. Topics: Animals; Anti-Inflammatory Agents; Biphenyl Compounds; Blotting, Western; Cell Line; Cyclooxygenase 2; Dinoprostone; Edema; Extracellular Signal-Regulated MAP Kinases; Immunohistochemistry; Macrophages; Mice; Nitric Oxide Synthase Type II; Propane; Tumor Necrosis Factor-alpha | 2012 |