Compounds > lasiodin
Page last updated: 2024-11-13

lasiodin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

lasiodin: has antineoplastic activity; isolated from Rabdosia serra; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
Rabdosiagenus[no description available]LamiaceaeThe mint plant family. They are characteristically aromatic, and many of them are cultivated for their oils. Most have square stems, opposite leaves, and two-lipped, open-mouthed, tubular corollas (united petals), with five-lobed, bell-like calyxes (united sepals).[MeSH]

Cross-References

ID SourceID
PubMed CID73348360
CHEMBL ID2368597
SCHEMBL ID16285420
MeSH IDM000601459

Synonyms (5)

Synonym
28957-08-6
CHEMBL2368597
lasiodin
SCHEMBL16285420
FS-7746

Research Excerpts

Treatment

ExcerptReferenceRelevance
"The treatment with lasiodin inhibited cell viability and migration."( Lasiodin inhibits proliferation of human nasopharyngeal carcinoma cells by simultaneous modulation of the Apaf-1/caspase, AKT/MAPK and COX-2/NF-κB signaling pathways.
Chen, W; Deng, W; Fu, L; Lin, L; Luo, W; Shi, D; Tian, Y; Wang, J; Zhao, M, 2014)		2.16
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (23)

Assay IDTitleYearJournalArticle
AID1702654Antiproliferative activity against mouse B16 cells assessed as reduction in cell viability after 48 hrs by MTT assay2020European journal of medicinal chemistry, Feb-01, Volume: 187Hydrogen sulfide releasing oridonin derivatives induce apoptosis through extrinsic and intrinsic pathways.
AID1702657Cytotoxicity against human PBMC cells assessed as cell viability after 48 hrs by MTT assay2020European journal of medicinal chemistry, Feb-01, Volume: 187Hydrogen sulfide releasing oridonin derivatives induce apoptosis through extrinsic and intrinsic pathways.
AID606255Cytotoxicity against human MCF7 cells after 48 hrs by MTT method2011Journal of natural products, May-27, Volume: 74, Issue:5
Structure and cytotoxicity of diterpenoids from Isodon adenolomus.
AID762093Cytotoxicity against human A549 cells after 48 hrs by MTT assay2013Journal of natural products, Jul-26, Volume: 76, Issue:7
Bioactive ent-kaurane diterpenoids from Isodon rosthornii.
AID1702652Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTT assay2020European journal of medicinal chemistry, Feb-01, Volume: 187Hydrogen sulfide releasing oridonin derivatives induce apoptosis through extrinsic and intrinsic pathways.
AID762095Cytotoxicity against human SMMC7721 cells after 48 hrs by MTT assay2013Journal of natural products, Jul-26, Volume: 76, Issue:7
Bioactive ent-kaurane diterpenoids from Isodon rosthornii.
AID1702655Antiproliferative activity against human K562 cells assessed as reduction in cell viability after 48 hrs by MTT assay2020European journal of medicinal chemistry, Feb-01, Volume: 187Hydrogen sulfide releasing oridonin derivatives induce apoptosis through extrinsic and intrinsic pathways.
AID1153328Antimycobacterial activity against Mycobacterium marinum ATCC 927 after 7 days2014Bioorganic & medicinal chemistry letters, Jul-01, Volume: 24, Issue:13
Design, synthesis and antimycobacterial activity evaluation of natural oridonin derivatives.
AID762092Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 18 hrs by Griess method2013Journal of natural products, Jul-26, Volume: 76, Issue:7
Bioactive ent-kaurane diterpenoids from Isodon rosthornii.
AID762090Cytotoxicity against mouse RAW264.7 cells after 18 hrs by MTS assay2013Journal of natural products, Jul-26, Volume: 76, Issue:7
Bioactive ent-kaurane diterpenoids from Isodon rosthornii.
AID606254Cytotoxicity against human A549 cells after 48 hrs by MTT method2011Journal of natural products, May-27, Volume: 74, Issue:5
Structure and cytotoxicity of diterpenoids from Isodon adenolomus.
AID1702653Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability after 48 hrs by MTT assay2020European journal of medicinal chemistry, Feb-01, Volume: 187Hydrogen sulfide releasing oridonin derivatives induce apoptosis through extrinsic and intrinsic pathways.
AID1153326Antimycobacterial activity against Mycobacterium phlei ATCC 355 after 1 day by alamar blue assay2014Bioorganic & medicinal chemistry letters, Jul-01, Volume: 24, Issue:13
Design, synthesis and antimycobacterial activity evaluation of natural oridonin derivatives.
AID1702651Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay2020European journal of medicinal chemistry, Feb-01, Volume: 187Hydrogen sulfide releasing oridonin derivatives induce apoptosis through extrinsic and intrinsic pathways.
AID606256Cytotoxicity against human SW480 cells after 48 hrs by MTT method2011Journal of natural products, May-27, Volume: 74, Issue:5
Structure and cytotoxicity of diterpenoids from Isodon adenolomus.
AID762091Cytotoxicity against human SW480 cells after 48 hrs by MTT assay2013Journal of natural products, Jul-26, Volume: 76, Issue:7
Bioactive ent-kaurane diterpenoids from Isodon rosthornii.
AID762094Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay2013Journal of natural products, Jul-26, Volume: 76, Issue:7
Bioactive ent-kaurane diterpenoids from Isodon rosthornii.
AID1702656Cytotoxicity against human L02 cells assessed as cell viability after 48 hrs by MTT assay2020European journal of medicinal chemistry, Feb-01, Volume: 187Hydrogen sulfide releasing oridonin derivatives induce apoptosis through extrinsic and intrinsic pathways.
AID606252Cytotoxicity against human HL60 cells after 48 hrs by MTT method2011Journal of natural products, May-27, Volume: 74, Issue:5
Structure and cytotoxicity of diterpenoids from Isodon adenolomus.
AID606253Cytotoxicity against human SMMC7721 cells after 48 hrs by MTT method2011Journal of natural products, May-27, Volume: 74, Issue:5
Structure and cytotoxicity of diterpenoids from Isodon adenolomus.
AID762096Cytotoxicity against human HL60 cells after 48 hrs by MTT assay2013Journal of natural products, Jul-26, Volume: 76, Issue:7
Bioactive ent-kaurane diterpenoids from Isodon rosthornii.
AID405779Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells assessed as nitrite formation2008Journal of natural products, Jun, Volume: 71, Issue:6
ent-Kaurane diterpenoids from Isodon japonicus.
AID1153327Antimycobacterial activity against Mycobacterium smegmatis ATCC 19420 after 1 day2014Bioorganic & medicinal chemistry letters, Jul-01, Volume: 24, Issue:13
Design, synthesis and antimycobacterial activity evaluation of natural oridonin derivatives.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (16.67)29.6817
2010's4 (66.67)24.3611
2020's1 (16.67)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 13.26

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index13.26 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index5.21 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (13.26)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
pimagedine
pimagedine: diamine oxidase & nitric oxide synthase inhibitor; an advanced glycosylation end product inhibitor; used in the treatment of diabetic complications; structure. aminoguanidine : A one-carbon compound whose unique structure renders it capable of acting as a derivative of hydrazine, guanidine or formamide.		2.0410guanidines;
one-carbon compound		EC 1.14.13.39 (nitric oxide synthase) inhibitor;
EC 1.4.3.4 (monoamine oxidase) inhibitor
fluorouracil
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.. 5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.		2.2510nucleobase analogue;
organofluorine compound		antimetabolite;
antineoplastic agent;
environmental contaminant;
immunosuppressive agent;
radiosensitizing agent;
xenobiotic
streptomycin
[no description available]		2.110antibiotic antifungal drug;
antibiotic fungicide;
streptomycins		antibacterial drug;
antifungal agrochemical;
antimicrobial agent;
antimicrobial drug;
bacterial metabolite;
protein synthesis inhibitor
paclitaxel
Taxus: Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL).		2.4820taxane diterpenoid;
tetracyclic diterpenoid		antineoplastic agent;
human metabolite;
metabolite;
microtubule-stabilising agent
benzyloxycarbonylleucyl-leucyl-leucine aldehyde
benzyloxycarbonylleucyl-leucyl-leucine aldehyde: proteasome inhibitor. N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal : A tripeptide that is L-leucyl-L-leucyl-L-leucine in which the C-terminal carboxy group has been reduced to the corresponding aldehyde and the N-terminal amino group is protected as its benzyloxycarbonyl derivative.		2.0810amino aldehyde;
carbamate ester;
tripeptide		proteasome inhibitor
desmethylanethol trithione
desmethylanethol trithione: metabolite of anethol trithione; structure given in first source		2.2510
oridonin
[no description available]		2.0810cyclic hemiketal;
enone;
ent-kaurane diterpenoid;
organic heteropentacyclic compound;
secondary alcohol		angiogenesis inhibitor;
anti-asthmatic agent;
antibacterial agent;
antineoplastic agent;
apoptosis inducer;
plant metabolite
cytochrome c-t
Cytochromes c: Cytochromes of the c type that are found in eukaryotic MITOCHONDRIA. They serve as redox intermediates that accept electrons from MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX III and transfer them to MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX IV.		2.110
ConditionIndicatedRelationship StrengthStudiesTrials
Nasopharyngeal Carcinoma
A carcinoma that originates in the EPITHELIUM of the NASOPHARYNX and includes four subtypes: keratinizing squamous cell, non-keratinizing, basaloid squamous cell, and PAPILLARY ADENOCARCINOMA. It is most prevalent in Southeast Asian populations and is associated with EPSTEIN-BARR VIRUS INFECTIONS. Somatic mutations associated with this cancer have been identified in NPCR, BAP1, UBAP1, ERBB2, ERBB3, MLL2, PIK3CA, KRAS, NRAS, and ARID1A genes.		07.110
Carcinoma, Anaplastic
[description not available]		02.110
Cancer of Nasopharynx
[description not available]		02.110
Carcinoma
A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm and not a synonym for cancer.		07.110
Nasopharyngeal Neoplasms
Tumors or cancer of the NASOPHARYNX.		02.110