lasiodin and oridonin

lasiodin has been researched along with oridonin* in 2 studies

*oridonin: Antineoplastic Agents, Phytogenic from Isodon; structure; RN given refers to (alpha,6beta,7alpha,14R)-isomer; RN for parent cpd not available 10;90 [MeSH]

*oridonin: Antineoplastic Agents, Phytogenic from Isodon; structure; RN given refers to (alpha,6beta,7alpha,14R)-isomer; RN for parent cpd not available 10;90 [MeSH]

Other Studies

2 other study(ies) available for lasiodin and oridonin

ArticleYear
Hydrogen sulfide releasing oridonin derivatives induce apoptosis through extrinsic and intrinsic pathways.
    European journal of medicinal chemistry, 2020, Feb-01, Volume: 187

    Hydrogen sulfide (H

    Topics: Apoptosis; Diterpenes, Kaurane; Dose-Response Relationship, Drug; Hep G2 Cells; Humans; Hydrogen Sulfide; K562 Cells; Membrane Potential, Mitochondrial; Molecular Structure; Structure-Activity Relationship

2020
Design, synthesis and antimycobacterial activity evaluation of natural oridonin derivatives.
    Bioorganic & medicinal chemistry letters, 2014, Jul-01, Volume: 24, Issue:13

    In an effort to develop novel potent antitubercular drugs, thirty-one oridonin derivatives were designed and prepared. All the compounds obtained were screened for their in vitro activities against Mycobacterium phlei, Mycobacterium smegmatis and Mycobacterium marinum. Among them, thirteen compounds showed significant inhibitory activity against M. phlei with MICs less than 2 μg/mL. Compounds 2k, 8d, 10c, 10d containing trans-cinnamic acid moiety were the most potent (MIC=0.5 μg/mL), comparable to the well-known antitubercular drug streptomycin. The preliminary structure-activity relationships (SARs) were also analyzed.

    Topics: Anti-Bacterial Agents; Diterpenes, Kaurane; Dose-Response Relationship, Drug; Drug Design; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium; Structure-Activity Relationship

2014