Compounds > kr 30450
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kr 30450

Description

KR 30450: activates the cardiac ATP-sensitive potassium channel; structure in first source [MeSH]

Cross-References

ID SourceID
PubMed CID9906213
MeSH IDM0254472

Synonyms (13)

Synonym
172489-10-0
skp-450
unii-48ye39tytk
kr-30450
2-(1'',3''-dioxolan-2''-yl)-2-methyl-4-(2'-oxo-1'-pyrrolidinyl)-6-nitro-2h-1-benzopyran
(-)-skp-450
2-pyrrolidinone, 1-(2-(1,3-dioxolan-2-yl)-2-methyl-6-nitro-2h-1-benzopyran-4-yl)-, (r)-
kr 30450
48YE39TYTK ,
(r)-1-(2-(1,3-dioxolan-2-yl)-2-methyl-6-nitro-2h-chromen-4-yl)pyrrolidin-2-one
2-(1',3'-dioxolan-2'-yl)-2-methyl-6-nitro -4-(2'-oxopyrrolidin-1'-yl)-2h-1-benzopyran
1-[(2r)-2-(1,3-dioxolan-2-yl)-2-methyl-6-nitrochromen-4-yl]pyrrolidin-2-one
AKOS040748674

Research

Studies (12)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's11 (91.67)18.2507
2000's1 (8.33)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (8.33%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other11 (91.67%)84.16%
SubstanceStudiesClassesRolesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
glyburide
3
monochlorobenzenes;
N-sulfonylurea		anti-arrhythmia drug;
EC 2.7.1.33 (pantothenate kinase) inhibitor;
EC 3.6.3.49 (channel-conductance-controlling ATPase) inhibitor;
hypoglycemic agent		1995199926.7medium003000
6-anilino-5,8-quinolinedione
1
aminoquinoline;
aromatic amine;
p-quinones;
quinolone		antineoplastic agent;
EC 4.6.1.2 (guanylate cyclase) inhibitor		1999199925.0low001000
pinacidil
1
pyridines1999199925.0low001000
desoxycorticosterone
1
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
mineralocorticoid;
primary alpha-hydroxy ketone		human metabolite;
mouse metabolite		1998199826.0low001000
pyrroles
3
pyrrole;
secondary amine		1995199827.0medium003000
copper sulfate
1
metal sulfateemetic;
fertilizer;
sensitiser		1999199925.0low001000
ng-nitroarginine methyl ester
1
alpha-amino acid ester;
L-arginine derivative;
methyl ester;
N-nitro compound		EC 1.14.13.39 (nitric oxide synthase) inhibitor1999199925.0low001000
nicorandil
1
nitrate ester;
pyridinecarboxamide		potassium channel opener;
vasodilator agent		1999199925.0low001000
cromakalim
6
1995199926.3high006000
aprikalim
1
1999199925.0low001000
charybdotoxin
1
1999199925.0low001000
ConditionIndicatedStudiesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
Anesthesia0
1
1998199826.0low001000
Bilateral Headache0
1
2000200024.0low101000
Blood Pressure, High0
3
1998199925.7medium003000
Disease Models, Animal0
1
1999199925.0low001000
Elevated Cholesterol0
1
1999199925.0low001000
Gastric Ulcer0
1
1999199925.0low001000
Headache0
1
2000200024.0low101000
Heart Disease, Ischemic0
1
1998199826.0low001000
Hypercholesterolemia0
1
1999199925.0low001000
Hypertension0
3
1998199925.7medium003000
Hypertension, Renal0
1
1998199826.0low001000
Injury, Myocardial Reperfusion0
1
1998199826.0low001000
Muscle Contraction0
1
1998199826.0low001000
Muscle Relaxation0
1
1999199925.0low001000
Myocardial Ischemia0
1
1998199826.0low001000
Stomach Ulcer0
1
1999199925.0low001000

Pharmacokinetics (1)

ArticleYear
Pharmacokinetic/pharmacodynamic evaluation of a novel potassium channel opener, SKP-450, in healthy volunteers.
Journal of clinical pharmacology, , Volume: 40, Issue:7		2000

Bioavailability (1)

ArticleYear
Disposition and metabolism of 2-(2''(1'',3''-dioxolan-2-yl)-2- methyl-4-(2'-oxopyrrolidin-1-Yl)-6-nitro-2h-1-benzopyran (SKP-450) in rats.
Drug metabolism and disposition: the biological fate of chemicals, , Volume: 27, Issue:4		1999

Dosage (1)

ArticleYear
Pharmacokinetic/pharmacodynamic evaluation of a novel potassium channel opener, SKP-450, in healthy volunteers.
Journal of clinical pharmacology, , Volume: 40, Issue:7		2000