Compounds > isamoxole
Page last updated: 2024-12-06

isamoxole

Description

isamoxole: potential anti-allergy cpd; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID42118
CHEMBL ID2105068
SCHEMBL ID637131
MeSH IDM0068170

Synonyms (35)

Synonym
nsc301203
57067-46-6
nsc-301203
propanamide, n-butyl-2-methyl-n-(4-methyl-2-oxazolyl)-
isamoxole
compound 90606
n-butyl-2-methyl-n-(4-methyl-2-oxazolyl)propionamide
isamoxole (usan/inn)
D04618
n-butyl-2-methyl-n-(4-methyl-1,3-oxazol-2-yl)propanamide
CHEMBL2105068
isamoxolum
nsc 301203
isamoxol [inn-spanish]
unii-24qib5vsgx
isamoxol
isamoxolum [inn-latin]
isamoxole [usan:inn:ban]
24qib5vsgx ,
ly 90606
isamoxole [inn]
compound-90606
isamoxole [usan]
SCHEMBL637131
2-(n-butylisobutyramido)-4-methyloxazole
4-methyl-2-(n-butyl isobutyramido)oxazole
4-methyl-2(n-butylisobutyramido)oxazole
2-(n-n-butyl-2-methylpropanamido)-4-methyloxazole
2-(n-butyl isobutyramido)-4-methyloxazole
n-butyl-2-methyl-n-(4-methyl-2-isoxazolyl)propionamide
2-(n-butyl-n-(2-methylpropanoyl))amino-4-methyl-oxazole
n-butyl-n-(4-methyloxazol-2-yl)-2-methylpropanamide
n-butyl-2-methyl-n-(4-methyl-1,3-oxazol-2-yl)propanamide #
DTXSID40205678
Q27253869

Research Excerpts

Overview

Isamoxole is a moderately potent, selective inhibitor of SRS-A activity on the guinea-pig ileum. It does not antagonize histamine, 5-hydroxytryptamine, or bradykinin.

ExcerptReferenceRelevance
"4. Isamoxole is a moderately potent, selective inhibitor of SRS-A activity on the guinea-pig ileum in vitro, at concentrations that do not antagonize histamine, 5-hydroxytryptamine, or bradykinin."( The pharmacology of isamoxole [2-methyl-n-butyl-n(4-methyloxazol-2-yl) propanamide] LRCL 3950, a new anti-allergic compound.
Dawson, W; Sweatman, WJ, 1980)		1.1
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (7)

Assay IDTitleYearJournalArticle
AID1124120Antianaphylactic activity in ovalbumin/ovalbumin aerosol sensitized guinea pig bronchospasm model assessed as ratio of mean collapse time after pretreatment with compound to mean collapse time of control animal at 2 x 100 mg/kg, po compound administered p1979Journal of medicinal chemistry, Apr, Volume: 22, Issue:4
Antianaphylactic agents. 1. 2-(Acylamino)oxazoles.
AID1124118Antianaphylactic activity in human chopped lung treated with atopic serum isolated from patients allergic to cocksfoot pollen assessed as inhibition of antigen-induced slow-reacting substance of anaphylaxis release at 10 ug/mL after 15 mins relative to co1979Journal of medicinal chemistry, Apr, Volume: 22, Issue:4
Antianaphylactic agents. 1. 2-(Acylamino)oxazoles.
AID1124115Antianaphylactic activity in ovalbumin sensitized albino guinea pig chopped lung assessed as inhibition of antigen-induced slow-reacting substance of anaphylaxis release at 10 ug/mL after 15 mins relative to control1979Journal of medicinal chemistry, Apr, Volume: 22, Issue:4
Antianaphylactic agents. 1. 2-(Acylamino)oxazoles.
AID1124117Antianaphylactic activity in human chopped lung treated with atopic serum isolated from patients allergic to cocksfoot pollen assessed as inhibition of antigen-induced histamine release at 10 ug/mL after 15 mins relative to control1979Journal of medicinal chemistry, Apr, Volume: 22, Issue:4
Antianaphylactic agents. 1. 2-(Acylamino)oxazoles.
AID1124116Antianaphylactic activity in ovalbumin sensitized albino guinea pig chopped lung assessed as inhibition of antigen-induced histamine release at 10 ug/mL after 15 mins relative to control1979Journal of medicinal chemistry, Apr, Volume: 22, Issue:4
Antianaphylactic agents. 1. 2-(Acylamino)oxazoles.
AID1124122Antianaphylactic activity in ovalbumin/ovalbumin aerosol sensitized guinea pig bronchospasm model assessed as ratio of mean collapse time after pretreatment with compound in presence of mepyramine to mean collapse time of control animal at 2 x 100 mg/kg, 1979Journal of medicinal chemistry, Apr, Volume: 22, Issue:4
Antianaphylactic agents. 1. 2-(Acylamino)oxazoles.
AID1124114Antianaphylactic activity in antiovalbumin IgE serum-treated Wistar rat at 2 x 100 mg/kg, po administered 2.5 hrs prior to ovalbumin challenge measured after 45 mins by passive cutaneous anaphylaxis test1979Journal of medicinal chemistry, Apr, Volume: 22, Issue:4
Antianaphylactic agents. 1. 2-(Acylamino)oxazoles.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19905 (83.33)18.7374
1990's0 (0.00)18.2507
2000's1 (16.67)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (16.67%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (83.33%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
melatonin
[no description available]		3.1410acetamides;
tryptamines		anticonvulsant;
central nervous system depressant;
geroprotector;
hormone;
human metabolite;
immunological adjuvant;
mouse metabolite;
radical scavenger
lidocaine
Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.. lidocaine : The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.		3.1410benzenes;
monocarboxylic acid amide;
tertiary amino compound		anti-arrhythmia drug;
drug allergen;
environmental contaminant;
local anaesthetic;
xenobiotic
indomethacin
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.. indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.		1.9610aromatic ether;
indole-3-acetic acids;
monochlorobenzenes;
N-acylindole		analgesic;
drug metabolite;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
environmental contaminant;
gout suppressant;
non-steroidal anti-inflammatory drug;
xenobiotic metabolite;
xenobiotic
ketotifen
Ketotifen: A cycloheptathiophene blocker of histamine H1 receptors and release of inflammatory mediators. It has been proposed for the treatment of asthma, rhinitis, skin allergies, and anaphylaxis.. ketotifen : An organic heterotricyclic compound that is 4,9-dihydro-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one which is substituted at position 4 by a 1-methylpiperidin-4-ylidene group. A blocker of histamine H1 receptors with a stabilising action on mast cells, it is used (usually as its hydrogen fumarate salt) for the treatment of asthma, where it may take several weeks to exert its full effect.		1.9510cyclic ketone;
olefinic compound;
organic heterotricyclic compound;
organosulfur heterocyclic compound;
piperidines;
tertiary amino compound		anti-asthmatic drug;
H1-receptor antagonist
meclofenamic acid
Meclofenamic Acid: A non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis.. meclofenamic acid : An aminobenzoic acid that is anthranilic acid in which one of the hydrogens attached to the nitrogen is replaced by a 2,6-dichloro-3-methylphenyl group. A non-steroidal anti-inflammatory drug, it is used as the sodium salt for the treatment of dysmenorrhoea (painful periods), osteoarthritis and rheumatoid arthritis.		1.9610aminobenzoic acid;
organochlorine compound;
secondary amino compound		analgesic;
anticonvulsant;
antineoplastic agent;
antipyretic;
antirheumatic drug;
EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
non-steroidal anti-inflammatory drug
methadone
Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3). methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.. 6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.		3.1410benzenes;
diarylmethane;
ketone;
tertiary amino compound
mitoxantrone
Mitoxantrone: An anthracenedione-derived antineoplastic agent.. mitoxantrone : A dihydroxyanthraquinone that is 1,4-dihydroxy-9,10-anthraquinone which is substituted by 6-hydroxy-1,4-diazahexyl groups at positions 5 and 8.		3.1410dihydroxyanthraquinoneanalgesic;
antineoplastic agent
pyrilamine
Pyrilamine: A histamine H1 antagonist. It has mild hypnotic properties and some local anesthetic action and is used for allergies (including skin eruptions) both parenterally and locally. It is a common ingredient of cold remedies.. mepyramine : An ethylenediamine derivative that is ethylenediamine in which one of the amino nitrogens is substituted by two methyl groups and the remaining amino nitrogen is substituted by a 4-methoxybenzyl and a pyridin-2-yl group.		1.9510aromatic ether;
ethylenediamine derivative		H1-receptor antagonist
phenidone
phenidone: photographic developer; RN given refers to parent cpd; structure		1.9610
oxazoles
Oxazoles: Five-membered heterocyclic ring structures containing an oxygen in the 1-position and a nitrogen in the 3-position, in distinction from ISOXAZOLES where they are at the 1,2 positions.. 1,3-oxazole : A five-membered monocyclic heteroarene that is an analogue of cyclopentadiene with O in place of CH2 at position 1 and N in place of CH at position 3.. oxazole : An azole based on a five-membered heterocyclic aromatic skeleton containing one N and one O atom.		4.16501,3-oxazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
etidocaine
Etidocaine: A local anesthetic with rapid onset and long action, similar to BUPIVACAINE.. etidocaine : An amino acid amide in which 2-[ethyl(propyl)amino]butanoic acid and 2,6-dimethylaniline have combined to form the amide bond. Used as a local anaesthetic (amide caine), it has rapid onset and long action properties, similar to bupivacaine, and is given by injection during surgical procedures and during labour and delivery.		3.1410amino acid amidelocal anaesthetic
tocainide
Tocainide: An antiarrhythmic agent which exerts a potential- and frequency-dependent block of SODIUM CHANNELS.. tocainide : A monocarboxylic acid amide in which 2,6-dimethylphenylaniline and isobutyric acid have combined to form the amide bond; used as a local anaesthetic.		3.1410monocarboxylic acid amideanti-arrhythmia drug;
local anaesthetic;
sodium channel blocker
bw-755c
4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine: A dual inhibitor of both cyclooxygenase and lipoxygenase pathways. It exerts an anti-inflammatory effect by inhibiting the formation of prostaglandins and leukotrienes. The drug also enhances pulmonary hypoxic vasoconstriction and has a protective effect after myocardial ischemia.		1.9610
proxicromil
proxicromil: RN given refers to parent cpd; structure		1.9610
masoprocol
Masoprocol: A potent lipoxygenase inhibitor that interferes with arachidonic acid metabolism. The compound also inhibits formyltetrahydrofolate synthetase, carboxylesterase, and cyclooxygenase to a lesser extent. It also serves as an antioxidant in fats and oils.. masoprocol : The meso-form of nordihydroguaiaretic acid. An antioxidant found in the creosote bush, Larrea divaricata, it is a potent lipoxygenase inhibitor that interferes with arachidonic acid metabolism. It also inhibits (though to a lesser extent) formyltetrahydrofolate synthetase, carboxylesterase, and cyclooxygenase.		1.9610nordihydroguaiaretic acidantineoplastic agent;
hypoglycemic agent;
lipoxygenase inhibitor;
metabolite
fpl 55712
FPL 55712: inhibitor of SRS-A and LTC4 and LTD4 receptors		1.9610aromatic ketone
ci 922
CI 922: inhibits IgE induced release of histamine		1.9610
n-formylmethionine leucyl-phenylalanine
N-Formylmethionine Leucyl-Phenylalanine: A formylated tripeptide originally isolated from bacterial filtrates that is positively chemotactic to polymorphonuclear leucocytes, and causes them to release lysosomal enzymes and become metabolically activated.. N-formyl-L-methionyl-L-leucyl-L-phenylalanine : A tripeptide composed of L-Met, L-Leu and L-Phe in a linear sequence with a formyl group at the amino terminus. It acts as a potent inducer of leucocyte chemotaxis and macrophage activator as well as a ligand for the FPR receptor.		1.9610tripeptide
ketotifen fumarate
ketotifen fumarate : An organoammonium salt consisting of equimolar amounts of ketotifen(1+) and fumarate(1-) ions. A blocker of histamine H1 receptors with a stabilising action on mast cells, it is a non-bronchodilator anti-asthmatic drug.		1.9510organoammonium saltanti-asthmatic drug;
H1-receptor antagonist
ConditionIndicatedRelationship StrengthStudiesTrials
Anaphylactic Reaction
[description not available]		01.9510
Bronchospasm
[description not available]		02.3620
Anaphylaxis
An acute hypersensitivity reaction due to exposure to a previously encountered ANTIGEN. The reaction may include rapidly progressing URTICARIA, respiratory distress, vascular collapse, systemic SHOCK, and death.		01.9510
Bronchial Spasm
Spasmodic contraction of the smooth muscle of the bronchi.		02.3620
Allergic Reaction
[description not available]		02.3620
Hypersensitivity
Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.		02.3620
chemdatabank.com