Page last updated: 2024-12-06

isamoxole

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

isamoxole: potential anti-allergy cpd; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID42118
CHEMBL ID2105068
SCHEMBL ID637131
MeSH IDM0068170

Synonyms (35)

Synonym
nsc301203
57067-46-6
nsc-301203
propanamide, n-butyl-2-methyl-n-(4-methyl-2-oxazolyl)-
isamoxole
compound 90606
n-butyl-2-methyl-n-(4-methyl-2-oxazolyl)propionamide
isamoxole (usan/inn)
D04618
n-butyl-2-methyl-n-(4-methyl-1,3-oxazol-2-yl)propanamide
CHEMBL2105068
isamoxolum
nsc 301203
isamoxol [inn-spanish]
unii-24qib5vsgx
isamoxol
isamoxolum [inn-latin]
isamoxole [usan:inn:ban]
24qib5vsgx ,
ly 90606
isamoxole [inn]
compound-90606
isamoxole [usan]
SCHEMBL637131
2-(n-butylisobutyramido)-4-methyloxazole
4-methyl-2-(n-butyl isobutyramido)oxazole
4-methyl-2(n-butylisobutyramido)oxazole
2-(n-n-butyl-2-methylpropanamido)-4-methyloxazole
2-(n-butyl isobutyramido)-4-methyloxazole
n-butyl-2-methyl-n-(4-methyl-2-isoxazolyl)propionamide
2-(n-butyl-n-(2-methylpropanoyl))amino-4-methyl-oxazole
n-butyl-n-(4-methyloxazol-2-yl)-2-methylpropanamide
n-butyl-2-methyl-n-(4-methyl-1,3-oxazol-2-yl)propanamide #
DTXSID40205678
Q27253869

Research Excerpts

Overview

Isamoxole is a moderately potent, selective inhibitor of SRS-A activity on the guinea-pig ileum. It does not antagonize histamine, 5-hydroxytryptamine, or bradykinin.

ExcerptReferenceRelevance
"4. Isamoxole is a moderately potent, selective inhibitor of SRS-A activity on the guinea-pig ileum in vitro, at concentrations that do not antagonize histamine, 5-hydroxytryptamine, or bradykinin."( The pharmacology of isamoxole [2-methyl-n-butyl-n(4-methyloxazol-2-yl) propanamide] LRCL 3950, a new anti-allergic compound.
Dawson, W; Sweatman, WJ, 1980
)
1.1
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (7)

Assay IDTitleYearJournalArticle
AID1124120Antianaphylactic activity in ovalbumin/ovalbumin aerosol sensitized guinea pig bronchospasm model assessed as ratio of mean collapse time after pretreatment with compound to mean collapse time of control animal at 2 x 100 mg/kg, po compound administered p1979Journal of medicinal chemistry, Apr, Volume: 22, Issue:4
Antianaphylactic agents. 1. 2-(Acylamino)oxazoles.
AID1124118Antianaphylactic activity in human chopped lung treated with atopic serum isolated from patients allergic to cocksfoot pollen assessed as inhibition of antigen-induced slow-reacting substance of anaphylaxis release at 10 ug/mL after 15 mins relative to co1979Journal of medicinal chemistry, Apr, Volume: 22, Issue:4
Antianaphylactic agents. 1. 2-(Acylamino)oxazoles.
AID1124115Antianaphylactic activity in ovalbumin sensitized albino guinea pig chopped lung assessed as inhibition of antigen-induced slow-reacting substance of anaphylaxis release at 10 ug/mL after 15 mins relative to control1979Journal of medicinal chemistry, Apr, Volume: 22, Issue:4
Antianaphylactic agents. 1. 2-(Acylamino)oxazoles.
AID1124117Antianaphylactic activity in human chopped lung treated with atopic serum isolated from patients allergic to cocksfoot pollen assessed as inhibition of antigen-induced histamine release at 10 ug/mL after 15 mins relative to control1979Journal of medicinal chemistry, Apr, Volume: 22, Issue:4
Antianaphylactic agents. 1. 2-(Acylamino)oxazoles.
AID1124116Antianaphylactic activity in ovalbumin sensitized albino guinea pig chopped lung assessed as inhibition of antigen-induced histamine release at 10 ug/mL after 15 mins relative to control1979Journal of medicinal chemistry, Apr, Volume: 22, Issue:4
Antianaphylactic agents. 1. 2-(Acylamino)oxazoles.
AID1124122Antianaphylactic activity in ovalbumin/ovalbumin aerosol sensitized guinea pig bronchospasm model assessed as ratio of mean collapse time after pretreatment with compound in presence of mepyramine to mean collapse time of control animal at 2 x 100 mg/kg, 1979Journal of medicinal chemistry, Apr, Volume: 22, Issue:4
Antianaphylactic agents. 1. 2-(Acylamino)oxazoles.
AID1124114Antianaphylactic activity in antiovalbumin IgE serum-treated Wistar rat at 2 x 100 mg/kg, po administered 2.5 hrs prior to ovalbumin challenge measured after 45 mins by passive cutaneous anaphylaxis test1979Journal of medicinal chemistry, Apr, Volume: 22, Issue:4
Antianaphylactic agents. 1. 2-(Acylamino)oxazoles.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19905 (83.33)18.7374
1990's0 (0.00)18.2507
2000's1 (16.67)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (16.67%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (83.33%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]