retinol transmembrane transporter activity
Definition
Target type: molecularfunction
Enables the transfer of retinol from one side of a membrane to the other. Retinol is vitamin A1, 2,6,6-trimethyl-1-(9'-hydroxy-3',7'-dimethylnona-1',3',5',7'-tetraenyl)cyclohex-1-ene, one of the three components that makes up vitamin A. [GOC:BHF, GOC:mah, GOC:vk]
Retinol transmembrane transporter activity is a molecular function associated with proteins involved in the transport of retinol (vitamin A) across cell membranes. Retinol is an essential nutrient that plays a crucial role in vision, immune function, cell growth and differentiation, and reproduction. Retinol transmembrane transporters facilitate the movement of retinol from the extracellular environment into the cell, where it can be utilized for various metabolic processes. These transporters typically exhibit high specificity for retinol and are often regulated by the concentration of retinol in the cell. They can be found in a variety of tissues, including the liver, intestines, retina, and skin. The activity of retinol transmembrane transporters is critical for maintaining retinol homeostasis and ensuring that adequate levels of retinol are available for cellular functions. Deficiencies in retinol transmembrane transporter activity can lead to various health problems, including night blindness, immune deficiency, and impaired growth.'
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Proteins (1)
| Protein | Definition | Taxonomy |
|---|---|---|
| Retinol-binding protein 4 | A retinol-binding protein 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P02753] | Homo sapiens (human) |
Compounds (5)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| retinol | all-trans-retinol : A retinol in which all four exocyclic double bonds have E- (trans-) geometry. retinol : A retinoid consisting of 3,7-dimethylnona-2,4,6,8-tetraen-1-ol substituted at position 9 by a 2,6,6-trimethylcyclohex-1-en-1-yl group (geometry of the four exocyclic double bonds is not specified). vitamin A : Any member of a group of fat-soluble retinoids produced via metabolism of provitamin A carotenoids that exhibit biological activity against vitamin A deficiency. Vitamin A is involved in immune function, vision, reproduction, and cellular communication. Vitamin A: Retinol and derivatives of retinol that play an essential role in metabolic functioning of the retina, the growth of and differentiation of epithelial tissue, the growth of bone, reproduction, and the immune response. Dietary vitamin A is derived from a variety of CAROTENOIDS found in plants. It is enriched in the liver, egg yolks, and the fat component of dairy products. | retinol; vitamin A | human metabolite; mouse metabolite; plant metabolite |
| fenretinide | 4-hydroxyphenyl retinamide : A retinoid obtained by formal condensation of the carboxy group of all-trans retinoic acid and the anilino group of 4-hydroxyaniline. Synthetic retinoid agonist. Antiproliferative, antioxidant and anticancer agent with a long half-life in vivo. Apoptotic effects appear to be mediated by a mechanism distinct from that of 'classical' retinoids. Fenretinide: A synthetic retinoid that is used orally as a chemopreventive against prostate cancer and in women at risk of developing contralateral breast cancer. It is also effective as an antineoplastic agent. | monocarboxylic acid amide; retinoid | antineoplastic agent; antioxidant |
| n-(2-hydroxyethyl)retinamide | N-(2-hydroxyethyl)retinamide: RN given refers to cpd without isomeric designation | ||
| tafamidis | tafamidis : A member of the class of 1,3-benzoxazoles that is 1,3-benzoxazole-6-carboxylic acid in which the hydrogen at position 2 is replaced by a 3,5-dichlorophenyl group. Used (as its meglumine salt) for the amelioration of transthyretin-related hereditary amyloidosis. tafamidis: may be effective in treating transthyretin amyloid polyneuropathy | 1,3-benzoxazoles; dichlorobenzene; monocarboxylic acid | central nervous system drug |
| idarucizumab |