enanthotoxin: poisonous principle of Oenanthe crocata (Water Dropwort); RN given refers to (E,E,E)-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| Flora | Rank | Flora Definition | Family | Family Definition |
|---|---|---|---|---|
| Oenanthe | genus | A plant genus of the family APIACEAE that is sometimes called Hemlock Water Dropwort but should not be confused with HEMLOCK. It contains enanthotoxin.[MeSH] | Apiaceae | A large plant family in the order Apiales, also known as Umbelliferae. Most are aromatic herbs with alternate, feather-divided leaves that are sheathed at the base. The flowers often form a conspicuous flat-topped umbel. Each small individual flower is usually bisexual, with five sepals, five petals, and an enlarged disk at the base of the style. The fruits are ridged and are composed of two parts that split open at maturity.[MeSH] |
| Oenanthe crocata | species | [no description available] | Apiaceae | A large plant family in the order Apiales, also known as Umbelliferae. Most are aromatic herbs with alternate, feather-divided leaves that are sheathed at the base. The flowers often form a conspicuous flat-topped umbel. Each small individual flower is usually bisexual, with five sepals, five petals, and an enlarged disk at the base of the style. The fruits are ridged and are composed of two parts that split open at maturity.[MeSH] |
| ID Source | ID |
|---|---|
| PubMed CID | 44138996 |
| CHEMBL ID | 550225 |
| CHEBI ID | 144406 |
| SCHEMBL ID | 1170273 |
| MeSH ID | M0056443 |
| Synonym |
|---|
| enanthotoxin |
| oenanthotoxin |
| CHEMBL550225 |
| unii-4gd5a2rg2n |
| 4gd5a2rg2n , |
| 20311-78-8 |
| C20044 |
| enanthotoxin [mi] |
| enanthotoxin, (+)- |
| (2e,8e,10e,14r)-2,8,10-heptadecatriene-4,6-diyne-1,14-diol |
| 2,8,10-heptadecatriene-4,6-diyne-1,14-diol, (2e,8e,10e,14r)- |
| enanthotoxin, (r)- |
| SCHEMBL1170273 |
| DTXSID60897236 |
| Q3080860 |
| (r,2e,8e,10e)-heptadeca-2,8,10-trien-4,6-diyne-1,14-diol |
| (2e,8e,10e,14r)-heptadeca-2,8,10-trien-4,6-diyne-1,14-diol |
| CHEBI:144406 |
| Class | Description |
|---|---|
| long-chain fatty alcohol | A fatty alcohol with a chain length ranging from C13 to C22. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID424755 | Antagonist activity at GABAA receptor in Wistar rat neuronal cells assessed inhibition of GABA-evoked response by patch-clamp technique | 2009 | Journal of natural products, May-22, Volume: 72, Issue:5 | Polyacetylenes from sardinian Oenanthe fistulosa: a molecular clue to risus sardonicus. |
| AID1239046 | Cytotoxicity against mouse NIH/3T3 cells after 96 hrs by sulforhodamine B assay | 2015 | Bioorganic & medicinal chemistry, Sep-01, Volume: 23, Issue:17 | Chemoenzymatic synthesis and cytotoxicity of oenanthotoxin and analogues. |
| AID1239045 | Cytotoxicity against human MCF7 cells after 96 hrs by sulforhodamine B assay | 2015 | Bioorganic & medicinal chemistry, Sep-01, Volume: 23, Issue:17 | Chemoenzymatic synthesis and cytotoxicity of oenanthotoxin and analogues. |
| AID1239042 | Cytotoxicity against human A2780 cells after 96 hrs by sulforhodamine B assay | 2015 | Bioorganic & medicinal chemistry, Sep-01, Volume: 23, Issue:17 | Chemoenzymatic synthesis and cytotoxicity of oenanthotoxin and analogues. |
| AID1239041 | Cytotoxicity against human 8505C cells after 96 hrs by sulforhodamine B assay | 2015 | Bioorganic & medicinal chemistry, Sep-01, Volume: 23, Issue:17 | Chemoenzymatic synthesis and cytotoxicity of oenanthotoxin and analogues. |
| AID1239043 | Cytotoxicity against human A549 cells after 96 hrs by sulforhodamine B assay | 2015 | Bioorganic & medicinal chemistry, Sep-01, Volume: 23, Issue:17 | Chemoenzymatic synthesis and cytotoxicity of oenanthotoxin and analogues. |
| AID1239044 | Cytotoxicity against human HT-29 cells after 96 hrs by sulforhodamine B assay | 2015 | Bioorganic & medicinal chemistry, Sep-01, Volume: 23, Issue:17 | Chemoenzymatic synthesis and cytotoxicity of oenanthotoxin and analogues. |
| AID1239040 | Cytotoxicity against human 518A2 cells after 96 hrs by sulforhodamine B assay | 2015 | Bioorganic & medicinal chemistry, Sep-01, Volume: 23, Issue:17 | Chemoenzymatic synthesis and cytotoxicity of oenanthotoxin and analogues. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 10 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (20.00) | 29.6817 |
| 2010's | 5 (25.00) | 24.3611 |
| 2020's | 1 (5.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (4.76%) | 6.00% |
| Case Studies | 4 (19.05%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 16 (76.19%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||