cAMP-dependent protein kinase type I-alpha regulatory subunit

A cAMP-dependent protein kinase type I-alpha regulatory subunit that is encoded in the genome of human. [PRO:DNx, UniProtKB:P10644]

Synonyms

Tissue-specific extinguisher 1;
TSE1

Research

Bioassay Publications (1)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	1 (100.00)	24.3611
2020's	0 (0.00)	2.80

Compounds (1)

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
cyclic amp, monosodium salt	Homo sapiens (human)	Kact	0.1330	1	1

Enables

This protein enables 7 target(s):

Target	Category	Definition
cAMP-dependent protein kinase inhibitor activity	molecular function	Binds to and stops, prevents or reduces the activity of a cAMP-dependent protein kinase. [GOC:mah]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
cAMP-dependent protein kinase regulator activity	molecular function	Modulation of the activity of the enzyme cAMP-dependent protein kinase. [GOC:ai]
protein domain specific binding	molecular function	Binding to a specific domain of a protein. [GOC:go_curators]
ubiquitin protein ligase binding	molecular function	Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins. [GOC:vp]
protein kinase A catalytic subunit binding	molecular function	Binding to one or both of the catalytic subunits of protein kinase A. [GOC:mah]
cAMP binding	molecular function	Binding to cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate). [GOC:ai]

Located In

This protein is located in 10 target(s):

Target	Category	Definition
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
multivesicular body	cellular component	A type of endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm. [PMID:11566881, PMID:16533950]
centrosome	cellular component	A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle. [GOC:mah, ISBN:0198547684]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
neuromuscular junction	cellular component	The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential. [GOC:nln]
plasma membrane raft	cellular component	A membrane raft that is part of the plasma membrane. [GOC:jl]
sperm connecting piece	cellular component	The segment of the sperm flagellum that attaches to the implantation fossa of the nucleus in the sperm head; from the remnant of the centriole at this point, the axoneme extends throughout the length of the flagellum. [GOC:cjm, MP:0009830]
ciliary base	cellular component	Area of the cilium (also called flagellum) where the basal body and the axoneme are anchored to the plasma membrane. The ciliary base encompasses the distal part of the basal body, transition fibers and transition zone and is structurally and functionally very distinct from the rest of the cilium. In this area proteins are sorted and filtered before entering the cilium, and many ciliary proteins localize specifically to this area. [GOC:cilia, GOC:krc, PMID:22653444]
glutamatergic synapse	cellular component	A synapse that uses glutamate as a neurotransmitter. [GOC:dos]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

Part Of

This protein is part of 3 target(s):

Target	Category	Definition
nucleotide-activated protein kinase complex	cellular component	A protein complex that possesses nucleotide-dependent protein kinase activity. The nucleotide can be AMP (in S. pombe and human) or ADP (in S. cerevisiae). [GOC:bhm, GOC:mah, GOC:vw]
protein-containing complex	cellular component	A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. [GOC:dos, GOC:mah]
cAMP-dependent protein kinase complex	cellular component	An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer. [PMID:18178622]

Involved In

This protein is involved in 12 target(s):

Target	Category	Definition
mesoderm formation	biological process	The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts. [GOC:go_curators]
regulation of protein phosphorylation	biological process	Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein. [GOC:hjd]
regulation of transcription by RNA polymerase II	biological process	Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH]
adenylate cyclase-activating G protein-coupled receptor signaling pathway	biological process	A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling. [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]
positive regulation of insulin secretion	biological process	Any process that activates or increases the frequency, rate or extent of the regulated release of insulin. [GOC:mah]
intracellular signal transduction	biological process	The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
sarcomere organization	biological process	The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs. [GOC:bf]
negative regulation of activated T cell proliferation	biological process	Any process that stops, prevents or reduces the rate or extent of activated T cell proliferation. [GOC:go_curators]
cardiac muscle cell proliferation	biological process	The expansion of a cardiac muscle cell population by cell division. [GOC:dph, GOC:rph, PMID:11161571]
cellular response to glucagon stimulus	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucagon stimulus. [GOC:mah]
negative regulation of cAMP/PKA signal transduction	biological process	Any process that stops, prevents or reduces the frequency, rate or extent of cAMP/PKA signal transduction. [PMID:17376027]
negative regulation of cAMP-dependent protein kinase activity	biological process	Any process that stops, prevents or reduces the frequency, rate or extent of cAMP-dependent protein kinase activity. [GOC:obol]