Compounds > bromonitromethane
Page last updated: 2024-12-06

bromonitromethane

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

bromonitromethane: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID68423
CHEMBL ID2335229
SCHEMBL ID1776160
MeSH IDM0527535

Synonyms (35)

Synonym
563-70-2
bromonitromethane
methane, bromonitro-
nitrobromomethane
einecs 209-258-0
bromonitromethane, technical grade, 90%
dnprvxjgnanvcz-uhfffaoysa-
bromo-nitromethane
inchi=1/ch2brno2/c2-1-3(4)5/h1h2
bromo(nitro)methane
eg63p9eur0 ,
unii-eg63p9eur0
ccris 9456
AKOS005208083
bdbm50428793
FT-0623252
.alpha.-bromonitromethane
CHEMBL2335229 ,
1-bromonitromethane
monobromonitromethane
DTXSID7060338
SCHEMBL1776160
STR00857
mfcd00007401
BBL102788
STL556595
4-methylbenzyl1h-1,2,4-triazol-3-ylsulfone
HY-131120
CS-0128873
AMY33516
Q27277165
bromo-nitro-methane
bromonitromethane, tech.
EN300-87636
Z1255485348

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" However, data on toxic effect from in vivo experiment is limited."( Comparative toxicity of chloro- and bromo-nitromethanes in mice based on a metabolomic method.
Wu, B; Xian, Q; Yin, J; Zhang, XX, 2017)		0.46
" This study sheds new light on dehalogenation and toxic processes of HNMs by oral exposure, which provides basic data for their human health risk assessment."( Rapid and complete dehalogenation of halonitromethanes in simulated gastrointestinal tract and its influence on toxicity.
Cherr, GN; Gong, T; Hu, S; Liu, S; Ren, H; Wu, B; Xian, Q; Yin, J; Zhang, XX, 2018)		0.48
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
UDP-N-acetylglucosamine 1-carboxyvinyltransferaseEscherichia coli K-12IC50 (µMol)6.20000.10004.21698.8000AID736770; AID736771
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (5)

Processvia Protein(s)Taxonomy
peptidoglycan biosynthetic processUDP-N-acetylglucosamine 1-carboxyvinyltransferaseEscherichia coli K-12
regulation of cell shapeUDP-N-acetylglucosamine 1-carboxyvinyltransferaseEscherichia coli K-12
peptidoglycan biosynthetic processUDP-N-acetylglucosamine 1-carboxyvinyltransferaseEscherichia coli K-12
UDP-N-acetylgalactosamine biosynthetic processUDP-N-acetylglucosamine 1-carboxyvinyltransferaseEscherichia coli K-12
cell divisionUDP-N-acetylglucosamine 1-carboxyvinyltransferaseEscherichia coli K-12
cell wall organizationUDP-N-acetylglucosamine 1-carboxyvinyltransferaseEscherichia coli K-12
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (2)

Processvia Protein(s)Taxonomy
UDP-N-acetylglucosamine 1-carboxyvinyltransferase activityUDP-N-acetylglucosamine 1-carboxyvinyltransferaseEscherichia coli K-12
transferase activityUDP-N-acetylglucosamine 1-carboxyvinyltransferaseEscherichia coli K-12
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (2)

Processvia Protein(s)Taxonomy
cytoplasmUDP-N-acetylglucosamine 1-carboxyvinyltransferaseEscherichia coli K-12
cytosolUDP-N-acetylglucosamine 1-carboxyvinyltransferaseEscherichia coli K-12
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (25)

Assay IDTitleYearJournalArticle
AID736375Induction of GSH-adduct formation in citrate buffer at100 uM by RP-LC/MS analysis2013Bioorganic & medicinal chemistry, Feb-01, Volume: 21, Issue:3
Chemical, biochemical and microbiological properties of a brominated nitrovinylfuran with broad-spectrum antibacterial activity.
AID736769Inhibition of Pseudomonas aeruginosa MurA expressed in Escherichia coli BL21(lambdaDE3) using UNAG and PEP as substrate incubated for 10 mins prior to PEP addition measured after 60 mins by spectrophotometric analysis2013Bioorganic & medicinal chemistry, Feb-01, Volume: 21, Issue:3
Chemical, biochemical and microbiological properties of a brominated nitrovinylfuran with broad-spectrum antibacterial activity.
AID736758Cytotoxicity against human A431 cells after 72 hrs by crystal violet staining method2013Bioorganic & medicinal chemistry, Feb-01, Volume: 21, Issue:3
Chemical, biochemical and microbiological properties of a brominated nitrovinylfuran with broad-spectrum antibacterial activity.
AID736380Half life of the compound in citrate buffer at pH 62013Bioorganic & medicinal chemistry, Feb-01, Volume: 21, Issue:3
Chemical, biochemical and microbiological properties of a brominated nitrovinylfuran with broad-spectrum antibacterial activity.
AID736754Cytotoxicity against human Capan1 cells after 72 hrs by crystal violet staining method2013Bioorganic & medicinal chemistry, Feb-01, Volume: 21, Issue:3
Chemical, biochemical and microbiological properties of a brominated nitrovinylfuran with broad-spectrum antibacterial activity.
AID736366Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 after 20 to 24 hrs by broth microdilution assay2013Bioorganic & medicinal chemistry, Feb-01, Volume: 21, Issue:3
Chemical, biochemical and microbiological properties of a brominated nitrovinylfuran with broad-spectrum antibacterial activity.
AID736760Cytotoxicity against human HaCaT cells after 72 hrs by crystal violet staining method2013Bioorganic & medicinal chemistry, Feb-01, Volume: 21, Issue:3
Chemical, biochemical and microbiological properties of a brominated nitrovinylfuran with broad-spectrum antibacterial activity.
AID736770Inhibition of Escherichia coli MurA C115D mutant expressed in Escherichia coli BL21(lambdaDE3) using UNAG and PEP as substrate incubated for 10 mins prior to PEP addition measured after 60 mins by spectrophotometric analysis2013Bioorganic & medicinal chemistry, Feb-01, Volume: 21, Issue:3
Chemical, biochemical and microbiological properties of a brominated nitrovinylfuran with broad-spectrum antibacterial activity.
AID736761Antibacterial activity against methicillin-resistant Staphylococcus aureus NCTC 10442 after 20 to 24 hrs by broth microdilution assay2013Bioorganic & medicinal chemistry, Feb-01, Volume: 21, Issue:3
Chemical, biochemical and microbiological properties of a brominated nitrovinylfuran with broad-spectrum antibacterial activity.
AID736768Inhibition of Staphylococcus aureus MurA2 expressed in Escherichia coli BL21(lambdaDE3) using UNAG and PEP as substrate incubated for 10 mins prior to PEP addition measured after 60 mins by spectrophotometric analysis2013Bioorganic & medicinal chemistry, Feb-01, Volume: 21, Issue:3
Chemical, biochemical and microbiological properties of a brominated nitrovinylfuran with broad-spectrum antibacterial activity.
AID736756Cytotoxicity against human Calu6 cells after 72 hrs by crystal violet staining method2013Bioorganic & medicinal chemistry, Feb-01, Volume: 21, Issue:3
Chemical, biochemical and microbiological properties of a brominated nitrovinylfuran with broad-spectrum antibacterial activity.
AID736757Cytotoxicity against human MeWo cells after 72 hrs by crystal violet staining method2013Bioorganic & medicinal chemistry, Feb-01, Volume: 21, Issue:3
Chemical, biochemical and microbiological properties of a brominated nitrovinylfuran with broad-spectrum antibacterial activity.
AID736755Cytotoxicity against human CaSki cells after 72 hrs by crystal violet staining method2013Bioorganic & medicinal chemistry, Feb-01, Volume: 21, Issue:3
Chemical, biochemical and microbiological properties of a brominated nitrovinylfuran with broad-spectrum antibacterial activity.
AID736367Antibacterial activity against Escherichia coli ATCC 25922 after 20 to 24 hrs by broth microdilution assay2013Bioorganic & medicinal chemistry, Feb-01, Volume: 21, Issue:3
Chemical, biochemical and microbiological properties of a brominated nitrovinylfuran with broad-spectrum antibacterial activity.
AID736374Induction of GSSG formation in citrate buffer at 100 uM by RP-LC/MS analysis2013Bioorganic & medicinal chemistry, Feb-01, Volume: 21, Issue:3
Chemical, biochemical and microbiological properties of a brominated nitrovinylfuran with broad-spectrum antibacterial activity.
AID736765Inhibition of human MetAP2 expressed in Escherichia coli BL21(lambdaDE3) using Met-AMC as substrate at 10 uM incubated for 30 mins prior to substrate addition measured for 15 mins fluorometric analysis2013Bioorganic & medicinal chemistry, Feb-01, Volume: 21, Issue:3
Chemical, biochemical and microbiological properties of a brominated nitrovinylfuran with broad-spectrum antibacterial activity.
AID736767Inhibition of Escherichia coli MetAP expressed in Escherichia coli BL21(lambdaDE3) using Met-AMC as substrate at 10 uM incubated for 30 mins prior to substrate addition measured for 15 mins fluorometric analysis2013Bioorganic & medicinal chemistry, Feb-01, Volume: 21, Issue:3
Chemical, biochemical and microbiological properties of a brominated nitrovinylfuran with broad-spectrum antibacterial activity.
AID736766Inhibition of human MetAP1 expressed in Escherichia coli BL21(lambdaDE3) using Met-AMC as substrate at 10 uM incubated for 30 mins prior to substrate addition measured for 15 mins fluorometric analysis2013Bioorganic & medicinal chemistry, Feb-01, Volume: 21, Issue:3
Chemical, biochemical and microbiological properties of a brominated nitrovinylfuran with broad-spectrum antibacterial activity.
AID736381Half life of the compound in tris buffer at pH 7.82013Bioorganic & medicinal chemistry, Feb-01, Volume: 21, Issue:3
Chemical, biochemical and microbiological properties of a brominated nitrovinylfuran with broad-spectrum antibacterial activity.
AID736764Inhibition of thrombin (unknown origin) expressed in Escherichia coli BL21(lambdaDE3) using Boc-Val-Pro-Arg-AMC as substrate at 25 uM incubated for 15 mins prior to substrate addition measured for 10 mins by fluorometric analysis2013Bioorganic & medicinal chemistry, Feb-01, Volume: 21, Issue:3
Chemical, biochemical and microbiological properties of a brominated nitrovinylfuran with broad-spectrum antibacterial activity.
AID736771Inhibition of Escherichia coli MurA expressed in Escherichia coli BL21(lambdaDE3) using UNAG and PEP as substrate incubated for 10 mins prior to PEP addition measured after 60 mins by spectrophotometric analysis2013Bioorganic & medicinal chemistry, Feb-01, Volume: 21, Issue:3
Chemical, biochemical and microbiological properties of a brominated nitrovinylfuran with broad-spectrum antibacterial activity.
AID736759Cytotoxicity against human Flow 2002 cells after 72 hrs by crystal violet staining method2013Bioorganic & medicinal chemistry, Feb-01, Volume: 21, Issue:3
Chemical, biochemical and microbiological properties of a brominated nitrovinylfuran with broad-spectrum antibacterial activity.
AID736753Cytotoxicity against human SW707 cells after 72 hrs by crystal violet staining method2013Bioorganic & medicinal chemistry, Feb-01, Volume: 21, Issue:3
Chemical, biochemical and microbiological properties of a brominated nitrovinylfuran with broad-spectrum antibacterial activity.
AID736762Antibacterial activity against methicillin-sensitive Staphylococcus aureus ATCC 25923 after 20 to 24 hrs by broth microdilution assay2013Bioorganic & medicinal chemistry, Feb-01, Volume: 21, Issue:3
Chemical, biochemical and microbiological properties of a brominated nitrovinylfuran with broad-spectrum antibacterial activity.
AID736763Inhibition of Dengue virus NS2B-NS3 protease expressed in Escherichia coli BL21(lambdaDE3) using Abz-NleKRRS-3-(NO2)Y as substrate at 50 uM incubated for 15 mins prior to substrate addition measured for 15 mins by fluorometric analysis2013Bioorganic & medicinal chemistry, Feb-01, Volume: 21, Issue:3
Chemical, biochemical and microbiological properties of a brominated nitrovinylfuran with broad-spectrum antibacterial activity.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (16)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (18.75)29.6817
2010's12 (75.00)24.3611
2020's1 (6.25)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 23.57

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index23.57 (24.57)
Research Supply Index2.83 (2.92)
Research Growth Index4.76 (4.65)
Search Engine Demand Index23.28 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (23.57)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other16 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
bromide
Bromides: Salts of hydrobromic acid, HBr, with the bromine atom in the 1- oxidation state. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)		2.0810halide anion;
monoatomic bromine
methane
Methane: The simplest saturated hydrocarbon. It is a colorless, flammable gas, slightly soluble in water. It is one of the chief constituents of natural gas and is formed in the decomposition of organic matter. (Grant & Hackh's Chemical Dictionary, 5th ed). methane : A one-carbon compound in which the carbon is attached by single bonds to four hydrogen atoms. It is a colourless, odourless, non-toxic but flammable gas (b.p. -161degreeC).		2.7830alkane;
gas molecular entity;
mononuclear parent hydride;
one-carbon compound		bacterial metabolite;
fossil fuel;
greenhouse gas
glycine
[no description available]		2.4820alpha-amino acid;
amino acid zwitterion;
proteinogenic amino acid;
serine family amino acid		EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor;
fundamental metabolite;
hepatoprotective agent;
micronutrient;
neurotransmitter;
NMDA receptor agonist;
nutraceutical
ethane
Ethane: A two carbon alkane with the formula H3C-CH3.. ethane : An alkane comprising of two carbon atoms.		4.17150alkane;
gas molecular entity		plant metabolite;
refrigerant
nitromethane
nitromethane: structure. nitromethane : A primary nitroalkane that is methane in which one of the hydrogens is replace by a nitro group. A polar solvent (b.p. 101 degreeC), it is an important starting material in organic synthesis. It is also used as a fuel for rockets and radio-controlled models.		7.5220primary nitroalkane;
volatile organic compound		EC 4.3.1.3 (histidine ammonia-lyase) inhibitor;
explosive;
NMR chemical shift reference compound;
polar aprotic solvent
chloropicrin
chloropicrin: major descriptor (66-85); on-line search HYDROCARBONS, CHLORINATED (66-85); Index Medicus search CHLOROPICRIN (66-85). chloropicrin : A C-nitro compound that is nitromethane in which all three hydrogens are replaced by chlorines. It is a severe irritant, and can cause immediate, severe inflammation of the eyes, nose and throat, and significant injuries to the upper and lower respiratory tract. Formerly stockpiled as a chemical warfare agent, it has been widely used in the US as a soil fumigant, particularly for strawberry crops. It is not approved for use within the European Union.		3.3360C-nitro compound;
one-carbon compound;
organochlorine compound		antifungal agrochemical;
fumigant insecticide;
nematicide
phenyl acetate
phenyl acetate: The ester formed between phenol and acetic acid. Don't confuse with phenylacetic acid derivatives listed under PHENYLACETATES.. phenyl acetate : An acetate ester obtained by the formal condensation of phenol with acetic acid.		2.0410benzenes;
phenyl acetates
alkenes
[no description available]		2.0810
fosfomycin
Fosfomycin: An antibiotic produced by Streptomyces fradiae.. fosfomycin : A phosphonic acid having an (R,S)-1,2-epoxypropyl group attached to phosphorus.		2.0810epoxide;
phosphonic acids		antimicrobial agent;
EC 2.5.1.7 (UDP-N-acetylglucosamine 1-carboxyvinyltransferase) inhibitor
2-bromo-5-(2-bromo-2-nitrovinyl)furan
2-bromo-5-(2-bromo-2-nitrovinyl)furan: structure in first source		2.0810
ConditionIndicatedRelationship StrengthStudiesTrials
Carcinogenesis
The origin, production or development of cancer through genotypic and phenotypic changes which upset the normal balance between cell proliferation and cell death. Carcinogenesis generally requires a constellation of steps, which may occur quickly or over a period of many years.		02.1510
Chromosome-Defective Micronuclei
[description not available]		02.0510
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		02.0610