Page last updated: 2024-10-24

UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity

Definition

Target type: molecularfunction

Catalysis of the reaction: phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine. [EC:2.5.1.7, RHEA:18681]

UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity catalyzes the transfer of the N-acetylglucosamine-1-phosphate moiety from UDP-N-acetylglucosamine to the carboxyl group of a protein, forming a glycosidic bond. This reaction is essential for the biosynthesis of peptidoglycan, a major component of bacterial cell walls. The enzyme typically recognizes a specific amino acid residue, often lysine, within the protein substrate. The formation of the glycosidic bond is a key step in the assembly of the peptidoglycan layer, which provides structural integrity to the bacterial cell. The enzyme is found in bacteria, archaea, and some eukaryotes, where it plays a vital role in cell wall formation and maintenance. '
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Proteins (1)

ProteinDefinitionTaxonomy
UDP-N-acetylglucosamine 1-carboxyvinyltransferaseA UDP-N-acetylglucosamine 1-carboxyvinyltransferase that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P0A749]Escherichia coli K-12

Compounds (9)

CompoundDefinitionClassesRoles
bromonitromethanebromonitromethane: structure in first source
alantolactonealantolactone : A sesquiterpene lactone that is 3a,5,6,7,8,8a,9,9a-octahydronaphtho[2,3-b]furan-2-one bearing two methyl substituents at positions 5 and 8a as well as a methylidene substituent at position 3.

alantolactone: allergenic sesquiterpene lactone; crystalline mixture of alantolactones from group of sesquiterpenes; structure
naphthofuran;
olefinic compound;
sesquiterpene lactone
antineoplastic agent;
apoptosis inducer;
plant metabolite
dehydrocostus lactonedehydrocostus lactone : An organic heterotricyclic compound and guaianolide sesquiterpene lactone that is acrylic acid which is substituted at position 2 by a 4-hydroxy-3,8-bis(methylene)decahydoazulen-5-yl group and in which the hydroxy group and the carboxy group have undergone formal condensation to afford the corresponding gamma-lactone.gamma-lactone;
guaiane sesquiterpenoid;
organic heterotricyclic compound;
sesquiterpene lactone
antimycobacterial drug;
antineoplastic agent;
apoptosis inducer;
cyclooxygenase 2 inhibitor;
metabolite;
trypanocidal drug
parthenolidegermacranolide
cynaropicrincynaropicrin: structure given in first source; RN given for ((3aR-(3aalpha,4alpha,6aalpha,8beta,9aalpha,9bbeta)))-isomersesquiterpene lactone
fosfomycinfosfomycin : A phosphonic acid having an (R,S)-1,2-epoxypropyl group attached to phosphorus.

Fosfomycin: An antibiotic produced by Streptomyces fradiae.
epoxide;
phosphonic acids
antimicrobial agent;
EC 2.5.1.7 (UDP-N-acetylglucosamine 1-carboxyvinyltransferase) inhibitor
costunolidegermacranolide;
heterobicyclic compound
anthelminthic drug;
antiinfective agent;
antineoplastic agent;
antiparasitic agent;
antiviral drug;
metabolite
eupatoriopicrinegermacranolide
2-bromo-5-(2-bromo-2-nitrovinyl)furan2-bromo-5-(2-bromo-2-nitrovinyl)furan: structure in first source