Target type: molecularfunction
Catalysis of the reaction: phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine. [EC:2.5.1.7, RHEA:18681]
UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity catalyzes the transfer of the N-acetylglucosamine-1-phosphate moiety from UDP-N-acetylglucosamine to the carboxyl group of a protein, forming a glycosidic bond. This reaction is essential for the biosynthesis of peptidoglycan, a major component of bacterial cell walls. The enzyme typically recognizes a specific amino acid residue, often lysine, within the protein substrate. The formation of the glycosidic bond is a key step in the assembly of the peptidoglycan layer, which provides structural integrity to the bacterial cell. The enzyme is found in bacteria, archaea, and some eukaryotes, where it plays a vital role in cell wall formation and maintenance. '
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| Protein | Definition | Taxonomy |
|---|---|---|
| UDP-N-acetylglucosamine 1-carboxyvinyltransferase | A UDP-N-acetylglucosamine 1-carboxyvinyltransferase that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P0A749] | Escherichia coli K-12 |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| bromonitromethane | bromonitromethane: structure in first source | ||
| alantolactone | alantolactone : A sesquiterpene lactone that is 3a,5,6,7,8,8a,9,9a-octahydronaphtho[2,3-b]furan-2-one bearing two methyl substituents at positions 5 and 8a as well as a methylidene substituent at position 3. alantolactone: allergenic sesquiterpene lactone; crystalline mixture of alantolactones from group of sesquiterpenes; structure | naphthofuran; olefinic compound; sesquiterpene lactone | antineoplastic agent; apoptosis inducer; plant metabolite |
| dehydrocostus lactone | dehydrocostus lactone : An organic heterotricyclic compound and guaianolide sesquiterpene lactone that is acrylic acid which is substituted at position 2 by a 4-hydroxy-3,8-bis(methylene)decahydoazulen-5-yl group and in which the hydroxy group and the carboxy group have undergone formal condensation to afford the corresponding gamma-lactone. | gamma-lactone; guaiane sesquiterpenoid; organic heterotricyclic compound; sesquiterpene lactone | antimycobacterial drug; antineoplastic agent; apoptosis inducer; cyclooxygenase 2 inhibitor; metabolite; trypanocidal drug |
| parthenolide | germacranolide | ||
| cynaropicrin | cynaropicrin: structure given in first source; RN given for ((3aR-(3aalpha,4alpha,6aalpha,8beta,9aalpha,9bbeta)))-isomer | sesquiterpene lactone | |
| fosfomycin | fosfomycin : A phosphonic acid having an (R,S)-1,2-epoxypropyl group attached to phosphorus. Fosfomycin: An antibiotic produced by Streptomyces fradiae. | epoxide; phosphonic acids | antimicrobial agent; EC 2.5.1.7 (UDP-N-acetylglucosamine 1-carboxyvinyltransferase) inhibitor |
| costunolide | germacranolide; heterobicyclic compound | anthelminthic drug; antiinfective agent; antineoplastic agent; antiparasitic agent; antiviral drug; metabolite | |
| eupatoriopicrine | germacranolide | ||
| 2-bromo-5-(2-bromo-2-nitrovinyl)furan | 2-bromo-5-(2-bromo-2-nitrovinyl)furan: structure in first source |