Roles > kisspeptin receptor agonist
Page last updated: 2024-08-05 15:50:18

kisspeptin receptor agonist

An agonist that acts at the kisspeptin receptor (KISS1R).

ChEBI ID: 141001

Members (1)

MemberDefinitionClass
RF9A dipeptide formed from L-arginine and L-phenylalaninamide residues in which a hydrogen attached to the nitrogen of the alpha-amino group of the arginine residue has been replaced by a 1-adamantanecarbonyl group. It has been reported to be a potent and selective antagonist of neuropeptide FF (NPFF) receptors, but more recently found to be an agonist at both NPFF1R and the kisspeptin receptor (KISS1R).RF9

Research

Studies (12)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (8.33)29.6817
2010's7 (58.33)24.3611
2020's4 (33.33)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other12 (100.00%)84.16%

Protein Targets (6)

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
KiSS-1 receptorHomo sapiens (human)IC500.830011
Neuropeptide FF receptor 1Homo sapiens (human)IC500.410011
Neuropeptide FF receptor 1Homo sapiens (human)Ki0.031333
Neuropeptide FF receptor 2Homo sapiens (human)IC500.410011
Neuropeptide FF receptor 2Homo sapiens (human)Ki0.045333

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Mas-related G-protein coupled receptor member X1Homo sapiens (human)EC50100.000011
Mas-related G-protein coupled receptor member X1Mus musculus (house mouse)EC500.316211
Mas-related G-protein coupled receptor member X1Rattus norvegicus (Norway rat)EC506.309611
Neuropeptide FF receptor 1Homo sapiens (human)EC501.744333
Neuropeptide FF receptor 2Homo sapiens (human)EC500.425522

Other Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Neuropeptide FF receptor 2Homo sapiens (human)Ke0.045011