Page last updated: 2024-12-06
6-thiocaffeine
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
6-Thiocaffeine, a sulfur analog of caffeine, exhibits a wide range of biological activities. It has been shown to possess anti-inflammatory, antioxidant, and anticancer properties. Research suggests that 6-Thiocaffeine may act as a potent inhibitor of adenosine deaminase, an enzyme involved in the breakdown of adenosine, leading to potential therapeutic applications in inflammatory diseases and immune disorders. Its synthesis typically involves the reaction of caffeine with phosphorus pentasulfide in a suitable solvent. The study of 6-Thiocaffeine is driven by its potential therapeutic benefits, particularly in the areas of inflammation, cancer, and neurological disorders.'
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 25768 |
| CHEMBL ID | 4591369 |
| SCHEMBL ID | 9257690 |
| MeSH ID | M0113892 |
Synonyms (15)
| Synonym |
|---|
| 2h-purin-2-one, 1,3,6,7-tetrahydro-1,3,7-trimethyl-6-thioxo- |
| caffeine, 6-thio- |
| brn 0205182 |
| m & b 6227 |
| 6-thiocaffeine |
| 1,3,7-trimethyl-6-sulfanylidenepurin-2-one |
| 13182-58-6 |
| 1,3,7-trimethyl-6-thioxo-2-oxopurine |
| AKOS015905618 |
| SCHEMBL9257690 |
| 1,3,7-trimethyl-6-thioxo-1,3,6,7-tetrahydro-2h-purin-2-one # |
| PYUDRFSIKNBDQS-UHFFFAOYSA-N |
| DTXSID70157217 |
| 1,3,7-trimethyl-6-thioxo-1,3,6,7-tetrahydro-purin-2-one |
| CHEMBL4591369 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Bioassays (6)
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1628622 | Hemolytic activity in human erythrocytes assessed as change in cell shape by measuring discocytes level at 0.1 mg/ml incubated for 60 mins by spectrophotometric analysis | 2016 | Bioorganic & medicinal chemistry letters, 08-15, Volume: 26, Issue:16 | Antioxidant properties of thio-caffeine derivatives: Identification of the newly synthesized 8-[(pyrrolidin-1-ylcarbonothioyl)sulfanyl]caffeine as antioxidant and highly potent cytoprotective agent. |
| AID1628623 | Induction of hemolysis in human erythrocytes assessed as effect on osmotic resistance at 0.1 mg/ml incubated for 60 mins by erythrocyte osmotic fragility assay | 2016 | Bioorganic & medicinal chemistry letters, 08-15, Volume: 26, Issue:16 | Antioxidant properties of thio-caffeine derivatives: Identification of the newly synthesized 8-[(pyrrolidin-1-ylcarbonothioyl)sulfanyl]caffeine as antioxidant and highly potent cytoprotective agent. |
| AID1628614 | Antioxidant activity assessed as DPPH radical scavenging activity at 0.025 to 0.1 mg/ml incubated for 30 mins in dark by spectrophotometric analysis | 2016 | Bioorganic & medicinal chemistry letters, 08-15, Volume: 26, Issue:16 | Antioxidant properties of thio-caffeine derivatives: Identification of the newly synthesized 8-[(pyrrolidin-1-ylcarbonothioyl)sulfanyl]caffeine as antioxidant and highly potent cytoprotective agent. |
| AID1628628 | Cytoprotection against AAPH-induced haemolysis in human erythrocytes at 0.01 to 1 mg/l pre-incubated for 20 mins before 60 mM AAPH addition for 4 hrs by spectrophotometric analysis | 2016 | Bioorganic & medicinal chemistry letters, 08-15, Volume: 26, Issue:16 | Antioxidant properties of thio-caffeine derivatives: Identification of the newly synthesized 8-[(pyrrolidin-1-ylcarbonothioyl)sulfanyl]caffeine as antioxidant and highly potent cytoprotective agent. |
| AID1628621 | Metal chelating activity of the compound assessed as inhibition of Fe2+-ferrozine complex formation incubated for 10 mins by spectrophotometric analysis | 2016 | Bioorganic & medicinal chemistry letters, 08-15, Volume: 26, Issue:16 | Antioxidant properties of thio-caffeine derivatives: Identification of the newly synthesized 8-[(pyrrolidin-1-ylcarbonothioyl)sulfanyl]caffeine as antioxidant and highly potent cytoprotective agent. |
| AID1628629 | Hemolytic activity in human erythrocytes at 0.1 mg/ml incubated for 60 mins by spectrophotometric analysis | 2016 | Bioorganic & medicinal chemistry letters, 08-15, Volume: 26, Issue:16 | Antioxidant properties of thio-caffeine derivatives: Identification of the newly synthesized 8-[(pyrrolidin-1-ylcarbonothioyl)sulfanyl]caffeine as antioxidant and highly potent cytoprotective agent. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
Research
Studies (4)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 3 (75.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 12.53
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.53) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||