Compounds > 6-thiocaffeine
Page last updated: 2024-12-06

6-thiocaffeine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

6-Thiocaffeine, a sulfur analog of caffeine, exhibits a wide range of biological activities. It has been shown to possess anti-inflammatory, antioxidant, and anticancer properties. Research suggests that 6-Thiocaffeine may act as a potent inhibitor of adenosine deaminase, an enzyme involved in the breakdown of adenosine, leading to potential therapeutic applications in inflammatory diseases and immune disorders. Its synthesis typically involves the reaction of caffeine with phosphorus pentasulfide in a suitable solvent. The study of 6-Thiocaffeine is driven by its potential therapeutic benefits, particularly in the areas of inflammation, cancer, and neurological disorders.'

Cross-References

ID SourceID
PubMed CID25768
CHEMBL ID4591369
SCHEMBL ID9257690
MeSH IDM0113892

Synonyms (15)

Synonym
2h-purin-2-one, 1,3,6,7-tetrahydro-1,3,7-trimethyl-6-thioxo-
caffeine, 6-thio-
brn 0205182
m & b 6227
6-thiocaffeine
1,3,7-trimethyl-6-sulfanylidenepurin-2-one
13182-58-6
1,3,7-trimethyl-6-thioxo-2-oxopurine
AKOS015905618
SCHEMBL9257690
1,3,7-trimethyl-6-thioxo-1,3,6,7-tetrahydro-2h-purin-2-one #
PYUDRFSIKNBDQS-UHFFFAOYSA-N
DTXSID70157217
1,3,7-trimethyl-6-thioxo-1,3,6,7-tetrahydro-purin-2-one
CHEMBL4591369
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (6)

Assay IDTitleYearJournalArticle
AID1628622Hemolytic activity in human erythrocytes assessed as change in cell shape by measuring discocytes level at 0.1 mg/ml incubated for 60 mins by spectrophotometric analysis2016Bioorganic & medicinal chemistry letters, 08-15, Volume: 26, Issue:16
Antioxidant properties of thio-caffeine derivatives: Identification of the newly synthesized 8-[(pyrrolidin-1-ylcarbonothioyl)sulfanyl]caffeine as antioxidant and highly potent cytoprotective agent.
AID1628623Induction of hemolysis in human erythrocytes assessed as effect on osmotic resistance at 0.1 mg/ml incubated for 60 mins by erythrocyte osmotic fragility assay2016Bioorganic & medicinal chemistry letters, 08-15, Volume: 26, Issue:16
Antioxidant properties of thio-caffeine derivatives: Identification of the newly synthesized 8-[(pyrrolidin-1-ylcarbonothioyl)sulfanyl]caffeine as antioxidant and highly potent cytoprotective agent.
AID1628614Antioxidant activity assessed as DPPH radical scavenging activity at 0.025 to 0.1 mg/ml incubated for 30 mins in dark by spectrophotometric analysis2016Bioorganic & medicinal chemistry letters, 08-15, Volume: 26, Issue:16
Antioxidant properties of thio-caffeine derivatives: Identification of the newly synthesized 8-[(pyrrolidin-1-ylcarbonothioyl)sulfanyl]caffeine as antioxidant and highly potent cytoprotective agent.
AID1628628Cytoprotection against AAPH-induced haemolysis in human erythrocytes at 0.01 to 1 mg/l pre-incubated for 20 mins before 60 mM AAPH addition for 4 hrs by spectrophotometric analysis2016Bioorganic & medicinal chemistry letters, 08-15, Volume: 26, Issue:16
Antioxidant properties of thio-caffeine derivatives: Identification of the newly synthesized 8-[(pyrrolidin-1-ylcarbonothioyl)sulfanyl]caffeine as antioxidant and highly potent cytoprotective agent.
AID1628621Metal chelating activity of the compound assessed as inhibition of Fe2+-ferrozine complex formation incubated for 10 mins by spectrophotometric analysis2016Bioorganic & medicinal chemistry letters, 08-15, Volume: 26, Issue:16
Antioxidant properties of thio-caffeine derivatives: Identification of the newly synthesized 8-[(pyrrolidin-1-ylcarbonothioyl)sulfanyl]caffeine as antioxidant and highly potent cytoprotective agent.
AID1628629Hemolytic activity in human erythrocytes at 0.1 mg/ml incubated for 60 mins by spectrophotometric analysis2016Bioorganic & medicinal chemistry letters, 08-15, Volume: 26, Issue:16
Antioxidant properties of thio-caffeine derivatives: Identification of the newly synthesized 8-[(pyrrolidin-1-ylcarbonothioyl)sulfanyl]caffeine as antioxidant and highly potent cytoprotective agent.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (4)

TimeframeStudies, This Drug (%)All Drugs %
pre-19903 (75.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (25.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.53

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.53 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.32 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.53)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
8-phenyltheophylline
8-phenyltheophylline: purinergic P1 receptor antagonist		1.9610
theophylline
[no description available]		2.6630dimethylxanthineadenosine receptor antagonist;
anti-asthmatic drug;
anti-inflammatory agent;
bronchodilator agent;
drug metabolite;
EC 3.1.4.* (phosphoric diester hydrolase) inhibitor;
fungal metabolite;
human blood serum metabolite;
immunomodulator;
muscle relaxant;
vasodilator agent
caffeine
[no description available]		2.940purine alkaloid;
trimethylxanthine		adenosine A2A receptor antagonist;
adenosine receptor antagonist;
adjuvant;
central nervous system stimulant;
diuretic;
EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor;
EC 3.1.4.* (phosphoric diester hydrolase) inhibitor;
environmental contaminant;
food additive;
fungal metabolite;
geroprotector;
human blood serum metabolite;
mouse metabolite;
mutagen;
plant metabolite;
psychotropic drug;
ryanodine receptor agonist;
xenobiotic
butylated hydroxytoluene
2,6-di-tert-butyl-4-methylphenol : A member of the class of phenols that is 4-methylphenol substituted by tert-butyl groups at positions 2 and 6.		2.1310phenolsantioxidant;
ferroptosis inhibitor;
food additive;
geroprotector
6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid
[no description available]		2.1310chromanol;
monocarboxylic acid;
phenols		antioxidant;
ferroptosis inhibitor;
neuroprotective agent;
radical scavenger;
Wnt signalling inhibitor
ConditionIndicatedRelationship StrengthStudiesTrials
Extravascular Hemolysis
[description not available]		02.1310
Hemolysis
The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.		02.1310
Muscle Relaxation
That phase of a muscle twitch during which a muscle returns to a resting position.		01.9710