Compounds > 5-dihydrocortisone
Page last updated: 2024-11-06

5-dihydrocortisone

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

5-Dihydrocortisone is a synthetic steroid that acts as an antagonist of the mineralocorticoid receptor. It has been studied for its potential use in the treatment of hyperkalemia and Conn's syndrome. The compound is synthesized from cortisone through a reduction reaction and exhibits weak glucocorticoid activity. Its effects are mediated through the interaction with the mineralocorticoid receptor, leading to decreased sodium retention and increased potassium excretion. The study of 5-dihydrocortisone is significant as it provides insights into the role of mineralocorticoid receptors in regulating electrolyte balance and potentially offers therapeutic benefits for specific medical conditions.'

5-dihydrocortisone: RN for cpd without isomeric designation not in Chemline 9/85 [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

17,21-dihydroxy-5beta-pregnane-3,11,20-trione : A 4,5-dihydrocortisone that has beta- configuration at position 5. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID65554
CHEBI ID18093
SCHEMBL ID727920
MeSH IDM0133463

Synonyms (36)

Synonym
5-dihydrocortisone
17,21-dihydroxy-5beta-pregnane-3,11,20-trione
CHEBI:18093
LMST02030095
5beta-pregnane-17alpha,21-diol-3,11,20-trione
C05469
68-54-2
17alpha,21-dihydroxy-5beta-pregnane-3,11,20-trione
4,5beta-dihydrocortisone
(5r,8s,9s,10s,13s,14s,17r)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,4,5,6,7,8,9,12,14,15,16-dodecahydrocyclopenta[a]phenanthrene-3,11-dione
6f8sz90823 ,
5beta-pregnan-17alpha,21-dihydroxy-3,11,20-trione
pregnane-3,11,20-trione, 17,21-dihydroxy-, (5beta)-
unii-6f8sz90823
5beta-dihydrocortisone
SCHEMBL727920
5??-dihydrocortisone
AKOS027381340
5.beta.-pregnan-3,11,20-trione-17.alpha.,21-diol
dihydrocortisone, (5.beta.)-
(5.beta.)-17,21-dihydroxypregnane-3,11,20-trione
5.beta.-pregnane-3,11,20-trione, 17,21-dihydroxy-
dihydrocortisone, (5beta)-
17,21-dihydroxy-5.beta.-pregnane-3,11,20-trione
17.alpha.,21-dihydroxy-5.beta.-pregnane-3,11,20-trione
4,5-beta-dihydrocortisone
17,21-dihydroxy-5b-pregnane-3,11,20-trione
4,5-b-dihydrocortisone
17a,21-dihydroxy-5b-pregnane-3,11,20-trione
17,21-dihydroxy-5-beta-pregnane-3,11,20-trione
(5beta)-dihydrocortisone
Q5276425
DTXSID70987415
CS-0146461
5|a-dihydrocortisone
HY-N8549
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (4)

ClassDescription
4,5-dihydrocortisoneA 3-oxo steroid that is cortisone in which the double bond between positions 4 and 5 has been reduced to a single bond.
3-oxo-5beta-steroidAny 3-oxo steroid that has beta- configuration at position 5.
primary alpha-hydroxy ketoneAn alpha-hydroxy ketone in which the carbonyl group and the hydroxy group are linked by a -CH2 (methylene) group.
tertiary alpha-hydroxy ketoneAn alpha-hydroxy ketone in which the carbonyl group and the hydroxy group are linked by a carbon bearing two organyl groups.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathways (15)

PathwayProteinsCompounds
Steroidogenesis1142
Adrenal Hyperplasia Type 3 or Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency1142
Congenital Lipoid Adrenal Hyperplasia (CLAH) or Lipoid CAH1142
Adrenal Hyperplasia Type 5 or Congenital Adrenal Hyperplasia Due to 17 alpha-Hydroxylase Deficiency1142
17-alpha-Hydroxylase Deficiency (CYP17)1142
11-beta-Hydroxylase Deficiency (CYP11B1)1142
21-Hydroxylase Deficiency (CYP21)1142
Corticosterone Methyl Oxidase I Deficiency (CMO I)1142
Corticosterone Methyl Oxidase II Deficiency (CMO II)1142
Apparent Mineralocorticoid Excess Syndrome1142
3-beta-Hydroxysteroid Dehydrogenase Deficiency1142
Glucocorticoid biosynthesis1411
Glucocorticoid & Mineralcorticoid Metabolism013
Biochemical pathways: part I0466
Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism325

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19904 (80.00)18.7374
1990's1 (20.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.51

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.51 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.31 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.51)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
taurine
[no description available]		1.9910amino sulfonic acid;
zwitterion		antioxidant;
Escherichia coli metabolite;
glycine receptor agonist;
human metabolite;
mouse metabolite;
nutrient;
radical scavenger;
Saccharomyces cerevisiae metabolite
indomethacin
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.. indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.		1.9610aromatic ether;
indole-3-acetic acids;
monochlorobenzenes;
N-acylindole		analgesic;
drug metabolite;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
environmental contaminant;
gout suppressant;
non-steroidal anti-inflammatory drug;
xenobiotic metabolite;
xenobiotic
pentoxifylline
[no description available]		1.9910oxopurine
thalidomide
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.. thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.. 2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.		1.9910phthalimides;
piperidones
taurolidine
[no description available]		1.9910thiadiazinane
phenyl acetate
phenyl acetate: The ester formed between phenol and acetic acid. Don't confuse with phenylacetic acid derivatives listed under PHENYLACETATES.. phenyl acetate : An acetate ester obtained by the formal condensation of phenol with acetic acid.		2.3420benzenes;
phenyl acetates
cyclosporine
Cyclosporine: A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes. It is used for the prophylaxis of graft rejection in organ and tissue transplantation. (From Martindale, The Extra Pharmacopoeia, 30th ed).		1.9910
ConditionIndicatedRelationship StrengthStudiesTrials
Hepatocellular Carcinoma
[description not available]		01.9910
Cancer of Liver
[description not available]		01.9910
Carcinoma, Hepatocellular
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.		01.9910
Liver Neoplasms
Tumors or cancer of the LIVER.		01.9910