Compounds > 3-hydroxytibolone
Page last updated: 2024-11-12

3-hydroxytibolone

Description

3-hydroxytibolone: tibolone metabolite [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID10087021
SCHEMBL ID7019917
MeSH IDM0466405

Synonyms (18)

Synonym
3alpha-hydroxytibolone
3-hydroxytibolone
org 4094
100239-44-9
SCHEMBL7019917
(3.alpha.,7.alpha.,17.alpha.)-7-methyl-19-norpregn-5(10)-en-20-yne-3,17-diol
37T303O94A ,
3.alpha.-hydroxytibolone
19-norpregn-5(10)-en-20-yne-3,17-diol, 7-methyl-, (3.alpha.,7.alpha.,17.alpha.)-
org-4094
(3r,7r,8r,9s,13s,14s,17r)-17-ethynyl-7,13-dimethyl-2,3,4,6,7,8,9,11,12,14,15,16-dodecahydro-1h-cyclopenta[a]phenanthrene-3,17-diol
unii-37t303o94a
19-norpregn-5(10)-en-20-yne-3,17-diol, 7-methyl-, (3alpha,7alpha,17alpha)-
(3alpha,7alpha,17alpha)-7-methyl-19-norpregn-5(10)-en-20-yne-3,17-diol
3a-hydroxytibolone
Q27256698
3?-hydroxy tibolone
DTXSID001315905

Research Excerpts

Pharmacokinetics

ExcerptReferenceRelevance
" The validated method was applied in a pharmacokinetic study with a tibolone formulation in healthy female volunteers."( Determination of 3-α-hydroxytibolone in human plasma by LC-MS/MS: application for a pharmacokinetic study after administration of a tibolone formulation.
Bonfim, RR; César, IC; da Silva, EP; de Santana e Silva Cardoso, FF; de Souza Teixeira, L; de Souza, WC; Ferreira, DP; Gomes, SA; Lopes, AR; Mundim, IM; Pascoal, HD; Pianetti, GA, 2013)		0.39

Dosage Studied

ExcerptRelevanceReference
" In plasma, the predominant nonsulfated metabolite after single and multiple dosing was the estrogenic 3alpha-hydroxytibolone; levels of the estrogenic 3beta-hydroxytibolone were 10-fold lower and of progestagenic/androgenic Delta(4)-tibolone, 5-fold lower."( Pharmacokinetic parameters of tibolone and metabolites in plasma, urine, feces, and bile from ovariectomized cynomolgus monkeys after a single dose or multiple doses of tibolone.
Delbressine, LP; Kloosterboer, HJ; Timmer, CJ; van Iersel, ML; Verheul, HA, 2007)		0.34
" Levels of disulfated metabolites in serum and tissues were higher (3- to 5-fold) after multiple dosing than after a single dose."( Levels of tibolone and estradiol and their nonsulfated and sulfated metabolites in serum, myometrium, and vagina of postmenopausal women following treatment for 21 days with tibolone, estradiol, or estradiol plus medroxyprogestrone acetate.
Blok, LJ; Burger, CW; Hanifi-Moghaddam, P; Kloosterboer, HJ; Verheul, HA, 2007)		0.34
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (10)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's9 (90.00)29.6817
2010's1 (10.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.54

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.54 (24.57)
Research Supply Index2.71 (2.92)
Research Growth Index4.25 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.54)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials2 (16.67%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other10 (83.33%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
estrone
Hydroxyestrones: Estrone derivatives substituted with one or more hydroxyl groups in any position. They are important metabolites of estrone and other estrogens.		3.421117-oxo steroid;
3-hydroxy steroid;
phenolic steroid;
phenols		antineoplastic agent;
bone density conservation agent;
estrogen;
human metabolite;
mouse metabolite
medroxyprogesterone acetate
[no description available]		3.421120-oxo steroid;
3-oxo-Delta(4) steroid;
acetate ester;
corticosteroid;
steroid ester		adjuvant;
androgen;
antineoplastic agent;
antioxidant;
female contraceptive drug;
inhibitor;
progestin;
synthetic oral contraceptive
phosphoadenosine phosphosulfate
Phosphoadenosine Phosphosulfate: 3'-Phosphoadenosine-5'-phosphosulfate. Key intermediate in the formation by living cells of sulfate esters of phenols, alcohols, steroids, sulfated polysaccharides, and simple esters, such as choline sulfate. It is formed from sulfate ion and ATP in a two-step process. This compound also is an important step in the process of sulfur fixation in plants and microorganisms.. 3'-phospho-5'-adenylyl sulfate : An adenosine bisphosphate having monophosphate groups at the 3'- and 5'-positions and a sulfo group attached to the phosphate at position 5'.		2.0310acyl sulfate;
adenosine bisphosphate;
purine ribonucleoside bisphosphate		Escherichia coli metabolite;
mouse metabolite
2,6-dichloro-4-nitrophenol
[no description available]		2.0310
tibolone
tibolone: used in prevention of postmenopausal osteoporosis. tibolone : Estran-3-one with a double bond between positions 5 and 10, and bearing both an ethynyl group and a hydroxy group at position 17 (R-configuration). A synthetic steroid hormone drug which acts as an agonist at all five type I steroid hormone receptors, it is used in the prevention of postmenopausal osteoporosis and for treatment of endometriosis.		5.498217beta-hydroxy steroid;
terminal acetylenic compound		bone density conservation agent;
hormone agonist
estrone sulfate
estrone sulfate: sulfoconjugated estrone; RN given refers to parent cpd		3.421117-oxo steroid;
steroid sulfate		human metabolite;
mouse metabolite
dinoprostone
prostaglandin E2 : Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostaglandins.		2.0310prostaglandins Ehuman metabolite;
mouse metabolite;
oxytocic
16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione
[no description available]		2.0410
17-ethinyl-7 alpha-methyl-19-nortestosterone
delta(4)-tibolone: metabolite of tibolone; has progestational activity without estrogenic activity seen in tibolone		4.1131
transforming growth factor beta
Transforming Growth Factor beta: A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.		2.0310
nitrophenols
Nitrophenols: PHENOLS carrying nitro group substituents.		2.0310
ConditionIndicatedRelationship StrengthStudiesTrials
Uterine Prolapse
Downward displacement of the UTERUS. It is classified in various degrees: in the first degree the UTERINE CERVIX is within the vaginal orifice; in the second degree the cervix is outside the orifice; in the third degree the entire uterus is outside the orifice.		03.4211
Nerve Degeneration
Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.		02.0310
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