Compounds > 3,4,5,6-tetrachlorocatechol
Page last updated: 2024-11-05

3,4,5,6-tetrachlorocatechol

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

3,4,5,6-Tetrachlorocatechol is a chlorinated catechol that has been studied as a potential environmental contaminant and a model compound for understanding the metabolism and toxicity of chlorinated aromatic compounds. It is formed as a byproduct of the production of chlorophenols, which are used in various industrial applications. 3,4,5,6-Tetrachlorocatechol is known to be toxic to aquatic organisms and can accumulate in the food chain. Studies have shown that it can induce oxidative stress and disrupt endocrine function in organisms. The compound is also known to be mutagenic and carcinogenic. Research on 3,4,5,6-tetrachlorocatechol aims to understand its environmental fate, toxicity, and mechanisms of action, as well as to develop methods for its remediation and prevention. '

3,4,5,6-tetrachlorocatechol: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

tetrachlorocatechol : A chlorocatechol that is catechol in which all of the hydrogens attached to the benzene ring are replaced by chlorines. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID14537
CHEBI ID26889
SCHEMBL ID68786
MeSH IDM0384062

Synonyms (42)

Synonym
tetrachlorpyrokatechin [czech]
brn 1876366
tetrachlorpyrokatechol [czech]
nsc 29027
3,4,5,6-tetrachloro-1,2-benzenediol
1,2-benzenediol, 3,4,5,6-tetrachloro-
ccris 4061
tetrachloro-1,2-benzenediol
1198-55-6
nsc29027
nsc-29027
pyrocatechol, tetrachloro-
tetrachlorocatechol
tetrachloropyrocatechol
3,4,5,6-tetrachlorocatechol
CHEBI:26889
3,4,5,6-tetrachlorobenzene-1,2-diol
C18240
FT-0659084
AKOS000121218
unii-5reg09ujo0
tetrachlorpyrokatechol
tetrachlorpyrokatechin
5reg09ujo0 ,
3,4,5,6-tetrachloro-benzene-1,2-diol
SCHEMBL68786
T3627
mfcd00002190
c6h2cl4o2
DTXSID4022151
J-524850
CS-W006000
tetrachlorocatechol, technical, >=95.0% (hplc)
F0001-0325
DS-4828
Q27109925
AMY13239
HY-W006000
EN300-21597
tetrachlorobenzene-1,2-diol
SY113179
Z104503558
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (2)

ClassDescription
chlorocatecholAny member of the class of catechols that is catechol substituted by at least one chloro group.
tetrachlorobenzeneAny member of the class of chlorobenzenes carrying four chloro groups at unspecified positions.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (9)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (11.11)18.2507
2000's7 (77.78)29.6817
2010's1 (11.11)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.79

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.79 (24.57)
Research Supply Index2.30 (2.92)
Research Growth Index5.10 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.79)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other9 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
chlorine
chloride : A halide anion formed when chlorine picks up an electron to form an an anion.		2.0510halide anion;
monoatomic chlorine		cofactor;
Escherichia coli metabolite;
human metabolite
methanol
Methanol: A colorless, flammable liquid used in the manufacture of FORMALDEHYDE and ACETIC ACID, in chemical synthesis, antifreeze, and as a solvent. Ingestion of methanol is toxic and may cause blindness.. primary alcohol : A primary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it.. methanol : The primary alcohol that is the simplest aliphatic alcohol, comprising a methyl and an alcohol group.		2.0410alkyl alcohol;
one-carbon compound;
primary alcohol;
volatile organic compound		amphiprotic solvent;
Escherichia coli metabolite;
fuel;
human metabolite;
mouse metabolite;
Mycoplasma genitalium metabolite
pentachlorophenol
PENTA: structure given in first source		2.4320aromatic fungicide;
chlorophenol;
organochlorine pesticide;
pentachlorobenzenes		human xenobiotic metabolite
2,3,4,6-tetrachlorophenol
2,3,4,6-tetrachlorophenol: RN given refers to parent cpd; see also record for tetrachlorophenol with locants for chloro groups not specified. 2,3,4,6-tetrachlorophenol : A tetrachlorophenol in which the chlorines are located at positions 2, 3, 4, and 6.		2.0510tetrachlorophenolxenobiotic metabolite
acetonitrile
acetonitrile: RN given refers to unlabeled cpd. acetonitrile : A nitrile that is hydrogen cyanide in which the hydrogen has been replaced by a methyl group.		2.0410aliphatic nitrile;
volatile organic compound		EC 3.5.1.4 (amidase) inhibitor;
NMR chemical shift reference compound;
polar aprotic solvent
1,2,3,4-tetrachlorobenzene
1,2,3,4-tetrachlorobenzene : A tetrachlorobenzene carrying chloro groups at positions 1, 2 , 3 and 4.. tetrachlorobenzene : Any member of the class of chlorobenzenes carrying four chloro groups at unspecified positions.		210tetrachlorobenzene
4-chlorocatechol
4-chlorocatechol : A chlorocatechol that is catechol substituted by a chloro group at position 4.		2.0110chlorocatechol;
monochlorobenzenes		bacterial xenobiotic metabolite
4,5-dichlorocatechol
[no description available]		210
2,3,4,5-tetrachlorophenate
tetrachlorophenol: RN given refers to cpd with unspecified isomeric designation; see also record for 2,3,4,6-tetrachlorophenol. tetrachlorophenol : A chlorophenol that is phenol in which four of the hydrogens attached to the benzene ring are replaced by chlorines.. 2,3,4,5-tetrachlorophenol : A tetrachlorophenol in which the chlorines are located at positions 2, 3, 4, and 5.		2.0510tetrachlorophenolxenobiotic metabolite
titanium
Titanium: A dark-gray, metallic element of widespread distribution but occurring in small amounts with atomic number, 22, atomic weight, 47.867 and symbol, Ti; specific gravity, 4.5; used for fixation of fractures.		2.0510titanium group element atom
fluorine
Fluorine: A nonmetallic, diatomic gas that is a trace element and member of the halogen family. It is used in dentistry as fluoride (FLUORIDES) to prevent dental caries.		2.0510diatomic fluorine;
gas molecular entity		NMR chemical shift reference compound
titanium dioxide
titanium dioxide: used medically as protectant against externally caused irritation & sunlight; high concentrations of dust may cause irritation to respiratory tract; RN given refers to titanium oxide (TiO2); structure. titanium dioxide : A titanium oxide with the formula TiO2. A naturally occurring oxide sourced from ilmenite, rutile and anatase, it has a wide range of applications.		2.0510titanium oxidesfood colouring
sodium azide
Sodium Azide: A cytochrome oxidase inhibitor which is a nitridizing agent and an inhibitor of terminal oxidation. (From Merck Index, 12th ed). sodium azide : The sodium salt of hydrogen azide (hydrazoic acid).		2.0510inorganic sodium saltantibacterial agent;
explosive;
mitochondrial respiratory-chain inhibitor;
mutagen
1,2,3,4-tetrachlorodibenzodioxin
1,2,3,4-tetrachlorodibenzodioxin: structure given in first source		2.0110polychlorinated dibenzodioxine
2,7-dichlorodibenzo-4-dioxin
[no description available]		2.0110
neocuproine
neocuproine: Spectrophotometric determination of copper and ultramicro blood sugar determinations; structure; RN given refers to parent cpd. neocuproine : A member of the class of phenanthrolines that is 1,10-phenanthroline bearing two methyl substituents at positions 2 and 9.		2.110phenanthrolineschelator;
copper chelator
3,5-di-tert-butylcatechol
3,5-di-tert-butylcatechol: structure given in first source		2.0410
chloranilic acid
chloranilic acid: structure		2.0410
1,7-phenanthroline
[no description available]		2.110phenanthroline
hydroxyl radical
Hydroxyl Radical: The univalent radical OH. Hydroxyl radical is a potent oxidizing agent.		2.0510oxygen hydride;
oxygen radical;
reactive oxygen species
silicon
Silicon: A trace element that constitutes about 27.6% of the earth's crust in the form of SILICON DIOXIDE. It does not occur free in nature. Silicon has the atomic symbol Si, atomic number 14, and atomic weight [28.084; 28.086].		2.0510carbon group element atom;
metalloid atom;
nonmetal atom
ConditionIndicatedRelationship StrengthStudiesTrials