19-nor-10-keto-25-hydroxyvitamin d3

Description

19-nor-10-keto-25-hydroxyvitamin D3 is a synthetic analog of vitamin D3, meaning it's a modified version created in a lab. It is not a naturally occurring compound.

**Key differences from natural vitamin D3:**

* **19-nor:** This modification removes the methyl group at the 19th carbon position, which is essential for binding to the vitamin D receptor (VDR). This means 19-nor-10-keto-25-hydroxyvitamin D3 has a **lower affinity for the VDR** compared to natural vitamin D3.
* **10-keto:** This modification adds a ketone group at the 10th carbon position.
* **25-hydroxy:** This indicates that the compound is already hydroxylated at the 25th carbon position, which is the first step in the activation of vitamin D3.

**Why it's important for research:**

Despite the differences, 19-nor-10-keto-25-hydroxyvitamin D3 has unique characteristics that make it valuable for research:

* **Increased stability:** It has a longer half-life in the body compared to natural vitamin D3, making it easier to study.
* **Potential for improved selectivity:** It may exhibit a different pharmacological profile than natural vitamin D3, potentially targeting specific pathways or tissues more effectively.
* **Potentially safer than high doses of natural vitamin D3:** Its lower affinity for the VDR may result in fewer side effects, especially at higher doses.

**Research applications:**

19-nor-10-keto-25-hydroxyvitamin D3 is being studied in various fields, including:

* **Cancer:** Research is investigating its potential role in cancer prevention and treatment, as it has shown anti-proliferative effects in some studies.
* **Autoimmune diseases:** Its immunomodulatory properties are being explored in the context of conditions like rheumatoid arthritis and multiple sclerosis.
* **Bone health:** It may have potential benefits for bone density and fracture prevention.
* **Cardiovascular disease:** Its anti-inflammatory and anti-proliferative effects may have implications for heart health.
* **Drug development:** Researchers are developing new analogs of 19-nor-10-keto-25-hydroxyvitamin D3 with even better pharmacological profiles and therapeutic potential.

**Important note:**

It's crucial to remember that 19-nor-10-keto-25-hydroxyvitamin D3 is still under investigation. While promising, it's not yet available for clinical use and further research is needed to confirm its safety and efficacy.

19-nor-10-keto-25-hydroxyvitamin D3: metabolite of calcifediol; RN given refers to (5(E))-isomer; RN & structure from first source; RN not in Chemline 10/83 [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]