Page last updated: 2024-12-11

19-nor-10-keto-25-hydroxyvitamin d3

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

19-nor-10-keto-25-hydroxyvitamin D3 is a synthetic analog of vitamin D3, meaning it's a modified version created in a lab. It is not a naturally occurring compound.

**Key differences from natural vitamin D3:**

* **19-nor:** This modification removes the methyl group at the 19th carbon position, which is essential for binding to the vitamin D receptor (VDR). This means 19-nor-10-keto-25-hydroxyvitamin D3 has a **lower affinity for the VDR** compared to natural vitamin D3.
* **10-keto:** This modification adds a ketone group at the 10th carbon position.
* **25-hydroxy:** This indicates that the compound is already hydroxylated at the 25th carbon position, which is the first step in the activation of vitamin D3.

**Why it's important for research:**

Despite the differences, 19-nor-10-keto-25-hydroxyvitamin D3 has unique characteristics that make it valuable for research:

* **Increased stability:** It has a longer half-life in the body compared to natural vitamin D3, making it easier to study.
* **Potential for improved selectivity:** It may exhibit a different pharmacological profile than natural vitamin D3, potentially targeting specific pathways or tissues more effectively.
* **Potentially safer than high doses of natural vitamin D3:** Its lower affinity for the VDR may result in fewer side effects, especially at higher doses.

**Research applications:**

19-nor-10-keto-25-hydroxyvitamin D3 is being studied in various fields, including:

* **Cancer:** Research is investigating its potential role in cancer prevention and treatment, as it has shown anti-proliferative effects in some studies.
* **Autoimmune diseases:** Its immunomodulatory properties are being explored in the context of conditions like rheumatoid arthritis and multiple sclerosis.
* **Bone health:** It may have potential benefits for bone density and fracture prevention.
* **Cardiovascular disease:** Its anti-inflammatory and anti-proliferative effects may have implications for heart health.
* **Drug development:** Researchers are developing new analogs of 19-nor-10-keto-25-hydroxyvitamin D3 with even better pharmacological profiles and therapeutic potential.

**Important note:**

It's crucial to remember that 19-nor-10-keto-25-hydroxyvitamin D3 is still under investigation. While promising, it's not yet available for clinical use and further research is needed to confirm its safety and efficacy.

19-nor-10-keto-25-hydroxyvitamin D3: metabolite of calcifediol; RN given refers to (5(E))-isomer; RN & structure from first source; RN not in Chemline 10/83 [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID6439023
MeSH IDM0117115

Synonyms (8)

Synonym
(2e,4r)-2-[(2e)-2-[(1s,3as,7ar)-1-[(2r)-6-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1h-inden-4-ylidene]ethylidene]-4-hydroxycyclohexan-1-one
19-nk-25 hvd3
19-nor-10-keto-25-hydroxyvitamin d3
10-oxo-19-nor-25-hydroxyvitamin d3
19-nor-10-oxo-25-hydroxyvitamin d3
19-nor-9,10-secocholesta-5,7-dien-4-one, 1,25-dihydroxy-, (1alpha,5e,7e)-
5(e)-19-nor-10-keto-25-hydroxycholecalciferol
85925-90-2
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (11)

TimeframeStudies, This Drug (%)All Drugs %
pre-199010 (90.91)18.7374
1990's0 (0.00)18.2507
2000's1 (9.09)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.65

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.65 (24.57)
Research Supply Index2.48 (2.92)
Research Growth Index4.14 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.65)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other11 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]