Page last updated: 2024-12-11

1-norokadaone

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

1-norokadaone is likely a typo, and you are likely referring to **1-nor-kadsuane**.

**1-Nor-kadsuane** is a natural product isolated from the Chinese medicinal plant *Kadsura coccinea*. It is a **sesquiterpene lactone**, meaning it is a compound with a 15-carbon skeleton derived from isoprene units and contains a lactone ring.

**Importance in Research:**

* **Anti-inflammatory properties:** 1-nor-kadsuane has been shown to exhibit potent anti-inflammatory activity in various experimental models. It inhibits the production of pro-inflammatory cytokines like TNF-α and IL-6, and it has been explored for its potential in treating inflammatory diseases like rheumatoid arthritis.
* **Anticancer activity:** Studies have demonstrated that 1-nor-kadsuane possesses anticancer activity against various cancer cell lines, including leukemia, breast, and colon cancer cells. It is believed to exert its anticancer effect by inducing apoptosis (programmed cell death) in cancer cells.
* **Neuroprotective effects:** Research suggests that 1-nor-kadsuane may have neuroprotective effects. It has been shown to protect against neuronal damage induced by oxidative stress and amyloid-β aggregation, which are implicated in neurodegenerative diseases like Alzheimer's disease.
* **Antimicrobial activity:** 1-nor-kadsuane has been shown to possess antimicrobial activity against certain bacteria and fungi. This could be useful in the development of new antimicrobial agents.

**Overall, 1-nor-kadsuane is a promising natural product with a wide range of biological activities, making it a valuable subject for further research. Scientists are exploring its potential applications in medicine, particularly in the development of novel drugs for inflammatory, cancerous, and neurodegenerative diseases.**

**It is important to note that research on 1-nor-kadsuane is still ongoing, and more research is needed to fully understand its mechanisms of action and potential therapeutic applications.**

Cross-References

ID SourceID
PubMed CID5789458
MeSH IDM0225577

Synonyms (4)

Synonym
1-norokadaone
AKOS025294291
1-[11-hydroxy-2-[(e)-4-[4-hydroxy-2-[1-hydroxy-3-(3-methyl-1,7-dioxaspiro[5.5]undecan-2-yl)butyl]-3-methylidenespiro[4a,7,8,8a-tetrahydro-4h-pyrano[3,2-b]pyran-6,5'-oxolane]-2'-yl]but-3-en-2-yl]-4-methyl-1,7-dioxaspiro[5.5]undec-4-en-8-yl]propan-2-one
J-005959
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's3 (60.00)18.2507
2000's2 (40.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]