Compounds > 1-(chloromethyl)silatrane
Page last updated: 2024-12-08

1-(chloromethyl)silatrane

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

## 1-(Chloromethyl)silatrane: A Powerful Tool in Research

1-(Chloromethyl)silatrane, also known as **chloromethyltris(2-hydroxyethyl)silane**, is a versatile organosilicon compound with a unique structure. It consists of a central silicon atom surrounded by three 2-hydroxyethyl groups and a chloromethyl group. This molecule is particularly important for research due to its:

**1. Reactivity:** The chloromethyl group in 1-(chloromethyl)silatrane acts as a reactive site, allowing for the formation of diverse derivatives through various chemical transformations. These transformations include:

* **Nucleophilic Substitution:** The chlorine atom can be readily replaced by various nucleophiles, such as amines, alkoxides, and thiols. This allows for the synthesis of a wide range of functionalized silatranes with specific properties.
* **Ring-Opening Reactions:** The silatrane framework can be opened under specific conditions, providing access to new silicon-containing compounds with different functionalities.

**2. Biological Activity:** 1-(Chloromethyl)silatrane and its derivatives have shown promising biological activity, particularly in the following areas:

* **Antimicrobial Agents:** Some derivatives exhibit antimicrobial activity against bacteria, fungi, and even viruses.
* **Anticancer Agents:** Certain silatrane-based compounds demonstrate cytotoxic effects against specific cancer cell lines.
* **Bioimaging Probes:** The unique structure and reactivity of silatranes allow them to be functionalized with fluorescent groups, making them valuable tools for bioimaging and drug delivery applications.

**3. Material Science Applications:** 1-(Chloromethyl)silatrane and its derivatives have found applications in the development of advanced materials, including:

* **Polymers and Composites:** The reactive chloromethyl group can be used to incorporate silatranes into polymer chains, enhancing their mechanical properties and thermal stability.
* **Nanomaterials:** Silatranes can be utilized for the synthesis of novel nanomaterials with controlled size and morphology, leading to unique optical and electronic properties.

**4. Chemical Reactivity Studies:** 1-(Chloromethyl)silatrane serves as a valuable model compound for studying the reactivity of silatrane systems. Its unique structure and reactivity provide insights into the behavior of silicon in different chemical environments, contributing to the advancement of silicon chemistry.

**In summary:** 1-(Chloromethyl)silatrane's reactivity, biological activity, and material science applications make it a crucial compound in research. It serves as a versatile building block for synthesizing new functional molecules, offering valuable insights into the chemistry and biology of silicon-containing compounds.

Silimin: contains collagen, hydroxyapatite & CM-silitrane; Russian compound; a biogenic composite material for dental implants [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID362521
CHEMBL ID2000017
SCHEMBL ID8418895
MeSH IDM0104675

Synonyms (33)

Synonym
42003-39-4
AKOS005429972
nsc626545
nsc-626545
chloromethylsilatrane
2,8,9-trioxa-5-aza-1-silabicyclo[3.3.3]undecane, 1-(chloromethyl)-
5-(chloromethyl)-4,6,11-trioxa-1-aza-5-silabicyclo[3.3.3]undecane
1-(chloromethyl)-2,8,9-trioxa-5-aza-1-silabicyclo[3.3.3]undecane
NCI60_008397
1-chloromethyl-2,8,9-trioxa-5-aza-1-sila-bicyclo[3.3.3]undecane
STK363119
2,8,9-trioxa-5-aza-1-silabicyclo(3.3.3)undecane, 1-(chloromethyl)-
silimin
1-(chloromethyl)silatrane
mival
1-(chloromethyl)-2,8,9-trioxa-5-aza-1-silabicyclo(3.3.3)undecane
1-chloromethylsilatrane
einecs 255-621-1
BBL000525
unii-7r9b5a0vph
7r9b5a0vph ,
1-(chloromethyl)-2,8,9-trioxa-5-aza-1- silabicyclo(3.3.3)undecane
1-chloromethyl silatrane
chloromethylsilatrane [who-dd]
2,8,9-trioxa-5-aza-1-silabicyclo(3.3.3)undecane, 1- (chloromethyl)-
CHEMBL2000017
SCHEMBL8418895
DTXSID2041383
mfcd00053377
1-chloromethyl-2,8,9-trioxa-5-aza-1-sila-bicyclo(3.3.3)undecane
VS-00636
Q27268749
CS-0357933
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (15)

TimeframeStudies, This Drug (%)All Drugs %
pre-19907 (46.67)18.7374
1990's7 (46.67)18.2507
2000's1 (6.67)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.03

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.03 (24.57)
Research Supply Index3.14 (2.92)
Research Growth Index4.17 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.03)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (4.76%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other20 (95.24%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
uracil
2,4-dihydroxypyrimidine: a urinary biomarker for bipolar disorder		1.9710pyrimidine nucleobase;
pyrimidone		allergen;
Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
prodrug;
Saccharomyces cerevisiae metabolite
corticosterone
[no description available]		1.961011beta-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
C21-steroid;
glucocorticoid;
primary alpha-hydroxy ketone		human metabolite;
mouse metabolite
alloxan
Alloxan: Acidic compound formed by oxidation of URIC ACID. It is isolated as an efflorescent crystalline hydrate.. alloxan : A member of the class of pyrimidones, the structure of which is that of perhydropyrimidine substituted at C-2, -4, -5 and -6 by oxo groups.		2.3720pyrimidonehyperglycemic agent;
metabolite
hydroxyproline
Hydroxyproline: A hydroxylated form of the imino acid proline. A deficiency in ASCORBIC ACID can result in impaired hydroxyproline formation.. hydroxyproline : A proline derivative that is proline substituted by at least one hydroxy group.		1.96104-hydroxyproline;
L-alpha-amino acid zwitterion		human metabolite;
mouse metabolite;
plant metabolite
tyrosine
Tyrosine: A non-essential amino acid. In animals it is synthesized from PHENYLALANINE. It is also the precursor of EPINEPHRINE; THYROID HORMONES; and melanin.. tyrosine : An alpha-amino acid that is phenylalanine bearing a hydroxy substituent at position 4 on the phenyl ring.		1.9610amino acid zwitterion;
erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid;
proteinogenic amino acid;
tyrosine		EC 1.3.1.43 (arogenate dehydrogenase) inhibitor;
fundamental metabolite;
micronutrient;
nutraceutical
triethanolamine
triethanolamine: RN given refers to parent cpd. triethanolamine : A tertiary amino compound that is ammonia in which each of the hydrogens is substituted by a 2-hydroxyethyl group.		1.9610amino alcohol;
tertiary amino compound;
triol		buffer;
surfactant
6-methyluracil
6-methyluracil: RN given refers to unlabeled cpd; structure. 6-methyluracil : A pyrimidone that is uracil with a methyl group at position 6.		1.9710pyrimidonemetabolite
durapatite
Durapatite: The mineral component of bones and teeth; it has been used therapeutically as a prosthetic aid and in the prevention and treatment of osteoporosis.. hydroxylapatite : A phosphate mineral with the formula Ca5(PO4)3(OH).		4.0731
2,3-diketogulonic acid
2,3-Diketogulonic Acid: Metabolite of ASCORBIC ACID and the oxidized form of the lactone DEHYDROASCORBIC ACID.. 2,3-diketogulonic acid : A carbohydrate acid formally derived from gulonic acid by oxidation of the -OH groups at positions 2 and 3 to keto groups.		2.3720
titanium
Titanium: A dark-gray, metallic element of widespread distribution but occurring in small amounts with atomic number, 22, atomic weight, 47.867 and symbol, Ti; specific gravity, 4.5; used for fixation of fractures.		1.9910titanium group element atom
galactose
aldohexose : A hexose with a (potential) aldehyde group at one end.		1.9610
glycogen
glycogen : A polydisperse, highly branched glucan composed of chains of D-glucopyranose residues in alpha(1->4) glycosidic linkage, joined together by alpha(1->6) glycosidic linkages. A small number of alpha(1->3) glycosidic linkages and some cumulative alpha(1->6) links also may occur. The branches in glycogen typically contain 8 to 12 glucose residues.		2.3720
methylthiouracil
Methylthiouracil: A thiourea antithyroid agent that inhibits the synthesis of thyroid hormone. It is used in the treatment of hyperthyroidism.		1.9610pyrimidone
silicon
Silicon: A trace element that constitutes about 27.6% of the earth's crust in the form of SILICON DIOXIDE. It does not occur free in nature. Silicon has the atomic symbol Si, atomic number 14, and atomic weight [28.084; 28.086].		3.4780carbon group element atom;
metalloid atom;
nonmetal atom
silatrane
silatrane: RN given refers to unspecified silatrane		2.3720
ConditionIndicatedRelationship StrengthStudiesTrials
Complication, Postoperative
[description not available]		03.3711
Postoperative Complications
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.		03.3711
Aseptic Necrosis of Femur Head
[description not available]		02.0210
Gastric Ulcer
[description not available]		07.6630
Stomach Ulcer
Ulceration of the GASTRIC MUCOSA due to contact with GASTRIC JUICE. It is often associated with HELICOBACTER PYLORI infection or consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).		02.6630
Bradykinesia
[description not available]		01.9810
Segond Fracture
[description not available]		02.3920
Tibial Fractures
Fractures of the TIBIA.		02.3920
Fractures, Closed
Fractures in which the break in bone is not accompanied by an external wound.		01.9910
Fractures, Compound
[description not available]		01.9910