1-(chloromethyl)silatrane and Stomach-Ulcer

A stimulating effect of methylethyl(silatrane-I-ilmethyl)-sulphonium iodides, 1-(ethoxy)silatranes and 1-(chloromethyl)silatrane on the processes of rat test acetate ulcer healing is studied. Silatranes efficiency is not inferior to oxyferriscorbone and exceeds that of methacil. It is shown that all preparations inhibit the processes of lipids peroxidation in the blood, in liposomes and stomach tissue.

Topics: 2,3-Diketogulonic Acid; Alloxan; Animals; Anti-Ulcer Agents; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Drug Combinations; Ferric Compounds; Lipid Peroxidation; Organosilicon Compounds; Rats; Silicon; Stomach Ulcer; Uracil

Topics: Adrenal Glands; Animals; Corticosterone; Epinephrine; Glycogen; Liver Glycogen; Male; Myocardium; Organosilicon Compounds; Rats; Silicon; Stomach Ulcer; Stress, Psychological

It has been demonstrated in rats with experimental gastric ulcer that 1-(chloromethyl) silatrane intensifies the development of granulation-fibrous tissue and favours optimization of the ratio of collagens and glycosaminoglycans, the main connective tissue biopolymers. Furthermore, 1-(chloromethyl) silatrane produces a more pronounced effect on hexosamine-containing glycoproteins in the ulcer tissue as compared with methyluracil and oxyferriscorbon. At the same time, judging by the time course of sialoproteins, the antiulcerous drugs, methyluracil and oxyferriscorbon, are much more effective antiinflammatory agents than 1-(chloromethyl)silatrane.

Topics: 2,3-Diketogulonic Acid; Alloxan; Animals; Anti-Ulcer Agents; Drug Combinations; Ferric Compounds; Hexosamines; Hexoses; Hexuronic Acids; Hydroxyproline; Methylthiouracil; Organosilicon Compounds; Rats; Sialic Acids; Silicon; Stomach Ulcer; Tyrosine