Page last updated: 2024-11-06
gamma-glutamyltyrosine
Description
Gamma-glutamyltyrosine (GGT) is a dipeptide formed by the conjugation of gamma-glutamic acid and tyrosine. It is a product of the enzyme gamma-glutamyl transferase (GGT), which plays a critical role in glutathione metabolism and detoxification. GGT is found in various tissues, including the liver, kidneys, and intestines. Increased levels of GGT in the blood are often associated with liver disease, alcohol abuse, and certain types of cancer. Studies on GGT are focused on its role in oxidative stress, inflammation, and its potential as a biomarker for various diseases.'
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gamma-glutamyltyrosine: RN given refers to (L)-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
gamma-Glu-Tyr : A dipeptide composed of L-glutamic acid and L-tyrosine joined by a peptide linkage. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
Cross-References
| ID Source | ID |
|---|
| PubMed CID | 94340 |
| CHEBI ID | 82969 |
| SCHEMBL ID | 159887 |
| MeSH ID | M0154246 |
Synonyms (21)
| Synonym |
|---|
| gamma-glutamyltyrosine |
| 7432-23-7 |
| gamma-glu-tyr |
| glutyrosine |
| einecs 231-076-5 |
| gamma-glutamyl-l-tyrosine |
| n-l-gamma-glutamyl-l-tyrosine |
| SCHEMBL159887 |
| l-gamma-glutamyl-l-tyrosine |
| CHEBI:82969 |
| (2s)-2-amino-4-{[(1s)-1-carboxy-2-(4-hydroxyphenyl)ethyl]carbamoyl}butanoic acid |
| mfcd00037212 |
| h--glu-tyr-oh |
| Q27156509 |
| h-glu(tyr-oh)-oh |
| n-(4-amino-4-carboxy-1-hydroxybutylidene)tyrosine |
| DTXSID00995841 |
| h-|a-glu-tyr-oh |
| (2s)-2-amino-5-[[(1s)-1-carboxy-2-(4-hydroxyphenyl)ethyl]amino]-5-oxopentanoic acid |
| HY-P4633 |
| CS-0655431 |
Roles (1)
| Role | Description |
|---|
| human metabolite | Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens). |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] |
Drug Classes (5)
| Class | Description |
|---|
| dipeptide | Any molecule that contains two amino-acid residues connected by peptide linkages. |
| secondary carboxamide | A carboxamide resulting from the formal condensation of a carboxylic acid with a primary amine; formula RC(=O)NHR(1). |
| dicarboxylic acid | Any carboxylic acid containing two carboxy groups. |
| primary amino compound | A compound formally derived from ammonia by replacing one hydrogen atom by an organyl group. |
| phenols | Organic aromatic compounds having one or more hydroxy groups attached to a benzene or other arene ring. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] |
Research
Studies (7)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|
| pre-1990 | 3 (42.86) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 12.02
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| Metric | This Compound (vs All) |
|---|
| Research Demand Index | 12.02 (24.57) | | Research Supply Index | 2.30 (2.92) | | Research Growth Index | 4.32 (4.65) | | Search Engine Demand Index | 0.00 (26.88) | | Search Engine Supply Index | 0.00 (0.95) |
| |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|
| Trials | 1 (12.50%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 7 (87.50%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |