Compounds > seryl-histidine
Page last updated: 2024-10-14

seryl-histidine

Description

seryl-histidine: both amino acids function together as key catalytic amino acids in the active sites of diverse enzymes as the serine- and thiol-proteases, lipases, and esterases [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Ser-His : A dipeptide formed from L-serine and L-histidine residues. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID7016094
CHEMBL ID123541
CHEBI ID73651
SCHEMBL ID2132240
MeSH IDM0382654

Synonyms (27)

Synonym
chebi:73651 ,
CHEMBL123541
SCHEMBL2132240
67726-09-4
l-histidine, n-l-seryl-
serylhistidine
l-seryl-l-histidine
s-h
ser-his
l-ser-l-his
DTXSID10426797
seryl-histidine
l-serinyl-l-histidine
s-h dipeptide
serinylhistidine
serine-histidine dipeptide
serine histidine dipeptide
sh dipeptide
CS-0104926
HY-126488
Q27143822
h-ser-his-oh
(s)-2-((s)-2-amino-3-hydroxypropanamido)-3-(1h-imidazol-4-yl)propanoic acid
MS-23423
(2s)-2-[[(2s)-2-amino-3-hydroxypropanoyl]amino]-3-(1h-imidazol-5-yl)propanoic acid
(2s)-2-[(2s)-2-amino-3-hydroxypropanamido]-3-(1h-imidazol-5-yl)propanoic acid
AKOS040733347
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
metaboliteAny intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (1)

ClassDescription
dipeptideAny molecule that contains two amino-acid residues connected by peptide linkages.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (1)

Assay IDTitleYearJournalArticle
AID227363DNA cleaving activity was determined; +++++ indicates 100% of Ser-His cleavage activity2004Bioorganic & medicinal chemistry letters, Jul-16, Volume: 14, Issue:14
Molecular modeling on DNA cleavage activity of seryl-histidine and related dipeptide.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (12)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's6 (50.00)29.6817
2010's6 (50.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (8.33%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other11 (91.67%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
aspartic acid
Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.. aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent. L-aspartic acid : The L-enantiomer of aspartic acid.		2.0810aspartate family amino acid;
aspartic acid;
L-alpha-amino acid;
proteinogenic amino acid		Escherichia coli metabolite;
mouse metabolite;
neurotransmitter
alanylglutamine
alanylglutamine: RN refers to (L-Glu)-isomer; dipeptiven is for parenteral use. Ala-Gln : A dipeptide formed from L-alanyl and L-glutamine residues.		2.1310dipeptide zwitterion;
dipeptide		metabolite
histidylphenylalanine
His-Phe : A dipeptide obtained by formal condensation of the carboxy group of L-histidine with the amino group of L-phenylalanine.		2.1310dipeptide
2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate
2-hydroxy-6-oxo-6-phenyl-2,4-hexadienoic acid: metabolic product of biphenyl; from Pseudomonas putida; RN given refers to cpd without isomeric designation; structure. 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid : Penta-2,4-dienoic acid in which the hydrogen at position 2 is substituted by hydroxy and one of the hydrogens at position 5 is substituted by a benzoyl group. It is a metabolic product of biphenyl from Pseudomonas putida.		2.0810
phosphorus
Phosphorus: A non-metal element that has the atomic symbol P, atomic number 15, and atomic weight 31. It is an essential element that takes part in a broad variety of biochemical reactions.		2.1710monoatomic phosphorus;
nonmetal atom;
pnictogen		macronutrient
muramidase
Muramidase: A basic enzyme that is present in saliva, tears, egg white, and many animal fluids. It functions as an antibacterial agent. The enzyme catalyzes the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrin. EC 3.2.1.17.		2.0210
ConditionIndicatedRelationship StrengthStudiesTrials