Page last updated: 2024-12-11

seryl-histidine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

seryl-histidine: both amino acids function together as key catalytic amino acids in the active sites of diverse enzymes as the serine- and thiol-proteases, lipases, and esterases [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Ser-His : A dipeptide formed from L-serine and L-histidine residues. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID7016094
CHEMBL ID123541
CHEBI ID73651
SCHEMBL ID2132240
MeSH IDM0382654

Synonyms (27)

Synonym
chebi:73651 ,
CHEMBL123541
SCHEMBL2132240
67726-09-4
l-histidine, n-l-seryl-
serylhistidine
l-seryl-l-histidine
s-h
ser-his
l-ser-l-his
DTXSID10426797
seryl-histidine
l-serinyl-l-histidine
s-h dipeptide
serinylhistidine
serine-histidine dipeptide
serine histidine dipeptide
sh dipeptide
CS-0104926
HY-126488
Q27143822
h-ser-his-oh
(s)-2-((s)-2-amino-3-hydroxypropanamido)-3-(1h-imidazol-4-yl)propanoic acid
MS-23423
(2s)-2-[[(2s)-2-amino-3-hydroxypropanoyl]amino]-3-(1h-imidazol-5-yl)propanoic acid
(2s)-2-[(2s)-2-amino-3-hydroxypropanamido]-3-(1h-imidazol-5-yl)propanoic acid
AKOS040733347
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
metaboliteAny intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (1)

ClassDescription
dipeptideAny molecule that contains two amino-acid residues connected by peptide linkages.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (1)

Assay IDTitleYearJournalArticle
AID227363DNA cleaving activity was determined; +++++ indicates 100% of Ser-His cleavage activity2004Bioorganic & medicinal chemistry letters, Jul-16, Volume: 14, Issue:14
Molecular modeling on DNA cleavage activity of seryl-histidine and related dipeptide.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (12)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's6 (50.00)29.6817
2010's6 (50.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.49

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.49 (24.57)
Research Supply Index2.56 (2.92)
Research Growth Index5.06 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.49)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (8.33%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other11 (91.67%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]