propylene glycol dinitrate

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

propylene glycol dinitrate: major volatile constituent of Otto Fuel II liquid propellant that causes vasodilation, lowered blood pressure, methemoglobin formation; monoamine oxidase inhibitor [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	22933
CHEMBL ID	206527
SCHEMBL ID	989882
MeSH ID	M0097795

Synonyms (33)

Synonym
1,2-propanediol, dinitrate
propylene dinitrate
propylene nitrate
isopropylene nitrate
1,2-propylene glycol dinitrate
nsc62614
propylene glycol dinitrate
1,2-propanediol dinitrate
6423-43-4
propylene glycol 1,2-dinitrate
nsc-62614
wln: wnoy1&1onw
pgdn
hsdb 6823
nsc 62614
brn 1709968
einecs 229-180-0
propane-1,2-diyl dinitrate
bdbm50186612
1,2-bis-nitrooxy-propane
1-nitrooxypropan-2-yl nitrate
CHEMBL206527 ,
AKOS006280147
unii-4by6t6y8d1
1,2-propanediol, 1,2-dinitrate
4-01-00-02497 (beilstein handbook reference)
1,2-pgdn
4by6t6y8d1 ,
1,2-propanediol dinitrate [hsdb]
SCHEMBL989882
PSXCGTLGGVDWFU-UHFFFAOYSA-N
DTXSID7027627
Q2113171

Research Excerpts

Overview

Propylene glycol dinitrate is a rapidly metabolized, nitrated ester explosive propellant. It has acute cardiovascular effects at lower levels of exposure and methemoglobinemia and vascular collapse at higher ones.

Excerpt	Reference	Relevance
"Propylene glycol dinitrate (PGDN) is a rapidly metabolized, nitrated ester explosive propellant with acute cardiovascular effects at lower levels of exposure and methemoglobinemia and vascular collapse at higher ones. "	( A review of propylene glycol dinitrate toxicology and epidemiology. Forman, SA, 1988)	2.1

Dosage Studied

Excerpt	Relevance	Reference
"Male Fischer-344 rats demonstrated a dose-response of blood pressure (BP) to increasing doses of propylene glycol dinitrate (PGDN), the major constituent of OTTO Fuel II (OFII) following administration by subcutaneous injection."	( Effect of exposure route on measurement of blood pressure by tail cuff in F-344 rats exposed to OTTO Fuel II. Drerup, JM; Godin, CS; Kimmel, EC; Leahy, HF; Pollard, DL, 1993)	0.5

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (3)

Assay ID	Title	Year	Journal	Article
AID264514	Antioxidant activity assessed as inhibition of TBARS production in ferrous salt/ascorbate-induced lipid peroxidation in Wistar rat liver microsomal membrane at 1 mM	2006	Journal of medicinal chemistry, May-18, Volume: 49, Issue:10	NO-donor phenols: a new class of products endowed with antioxidant and vasodilator properties.
AID264515	Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips	2006	Journal of medicinal chemistry, May-18, Volume: 49, Issue:10	NO-donor phenols: a new class of products endowed with antioxidant and vasodilator properties.
AID264517	Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips at 100 uM in presence of 1 uM ODQ	2006	Journal of medicinal chemistry, May-18, Volume: 49, Issue:10	NO-donor phenols: a new class of products endowed with antioxidant and vasodilator properties.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (14)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	9 (64.29)	18.7374
1990's	3 (21.43)	18.2507
2000's	2 (14.29)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 24.70

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	24.70 (24.57)
Research Supply Index	2.77 (2.92)
Research Growth Index	4.14 (4.65)
Search Engine Demand Index	26.67 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (24.70)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (6.67%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	14 (93.33%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
nitrates Nitrates: Inorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical.	2	1	monovalent inorganic anion; nitrogen oxoanion; reactive nitrogen species
4-cresol 4-cresol: RN given refers to parent cpd. p-cresol : A cresol that consists of toluene substituted by a hydroxy group at position 4. It is a metabolite of aromatic amino acid metabolism produced by intestinal microflora in humans and animals.	2.03	1	cresol	Escherichia coli metabolite; human metabolite; uremic toxin
nitroglycerin Nitroglycerin: A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.. nitroglycerol : A nitrate ester that is glycerol in which nitro group(s) replace the hydrogen(s) attached to one or more of the hydroxy groups.. nitroglycerin : A nitroglycerol that is glycerol in which the hydrogen atoms of all three hydroxy groups are replaced by nitro groups. It acts as a prodrug, releasing nitric oxide to open blood vessels and so alleviate heart pain.	2	1	nitroglycerol	explosive; muscle relaxant; nitric oxide donor; prodrug; tocolytic agent; vasodilator agent; xenobiotic
propyl nitrate propyl nitrate: C3-H7-N-O3	2.03	1
butylated hydroxytoluene 2,6-di-tert-butyl-4-methylphenol : A member of the class of phenols that is 4-methylphenol substituted by tert-butyl groups at positions 2 and 6.	2.03	1	phenols	antioxidant; ferroptosis inhibitor; food additive; geroprotector
2,2,5,7,8-pentamethyl-1-hydroxychroman 2,2,5,7,8-pentamethyl-1-hydroxychroman: a Vitamin E derivative. chromanol : Any member of the class of chromanes that is chromane substituted by one or more hydroxy groups.	2.03	1
riboflavin vitamin B2 : Any member of a group of vitamers that belong to the chemical structural class called flavins that exhibit biological activity against vitamin B2 deficiency. Symptoms associated with vitamin B2 deficiency include glossitis, seborrhea, angular stomaitis, cheilosis and photophobia. The vitamers include riboflavin and its phosphate derivatives (and includes their salt, ionised and hydrate forms).	2	1	flavin; vitamin B2	anti-inflammatory agent; antioxidant; cofactor; Escherichia coli metabolite; food colouring; fundamental metabolite; human urinary metabolite; mouse metabolite; photosensitizing agent; plant metabolite
5-deazaflavin [no description available]	2	1	pyridopyrimidine
4-ethoxy-3-phenylsulfonylfuroxan [no description available]	2.03	1

Condition	Relationship Strength	Studies
Muscle Contraction A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.	2.03	1
Ataxia Impairment of the ability to perform smoothly coordinated voluntary movements. This condition may affect the limbs, trunk, eyes, pharynx, larynx, and other structures. Ataxia may result from impaired sensory or motor function. Sensory ataxia may result from posterior column injury or PERIPHERAL NERVE DISEASES. Motor ataxia may be associated with CEREBELLAR DISEASES; CEREBRAL CORTEX diseases; THALAMIC DISEASES; BASAL GANGLIA DISEASES; injury to the RED NUCLEUS; and other conditions.	6.96	1
Bilateral Headache [description not available]	1.96	1
Headache The symptom of PAIN in the cranial region. It may be an isolated benign occurrence or manifestation of a wide variety of HEADACHE DISORDERS.	1.96	1
Cephalgia, Vascular [description not available]	1.98	1
Angor Pectoris [description not available]	1.97	1
Arrhythmia [description not available]	1.97	1
Cardiovascular Stroke [description not available]	1.97	1
Diseases, Occupational [description not available]	1.97	1
Angina Pectoris The symptom of paroxysmal pain consequent to MYOCARDIAL ISCHEMIA usually of distinctive character, location and radiation. It is thought to be provoked by a transient stressful situation during which the oxygen requirements of the MYOCARDIUM exceed that supplied by the CORONARY CIRCULATION.	1.97	1
Arrhythmias, Cardiac Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.	1.97	1
Myocardial Infarction NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).	1.97	1
Methemoglobinemia The presence of methemoglobin in the blood, resulting in cyanosis. A small amount of methemoglobin is present in the blood normally, but injury or toxic agents convert a larger proportion of hemoglobin into methemoglobin, which does not function reversibly as an oxygen carrier. Methemoglobinemia may be due to a defect in the enzyme NADH methemoglobin reductase (an autosomal recessive trait) or to an abnormality in hemoglobin M (an autosomal dominant trait). (Dorland, 27th ed)	1.96	1

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