phakellistatin-2 and Leukemia-P388

phakellistatin-2 has been researched along with Leukemia-P388* in 1 studies

Other Studies

1 other study(ies) available for phakellistatin-2 and Leukemia-P388

Article	Year
Solid-phase total synthesis of cyclic decapeptide phakellistatin 12. Journal of natural products, 2008, Volume: 71, Issue:6 Pakellistatin 12 (1) is a new cancer cell growth inhibitory (P388 ED 50 2.8 microg/mL) cyclodecapeptide that was isolated from a marine sponge Phakellia sp. The first total synthesis of compound 1 is reported here using solid-phase methodology with safety-catch linker strategy. For the sequence of amino acids in the cycle, the peptide product was analyzed with a MALDI TOF/TOF instrument, and the structure of the synthetic product was found to be chemically and spectroscopically identical to the natural substance. Topics: Animals; Antineoplastic Agents; Leukemia P388; Mice; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Peptides, Cyclic; Porifera	2008

Article

Year

Solid-phase total synthesis of cyclic decapeptide phakellistatin 12.

Journal of natural products, 2008, Volume: 71, Issue:6

Pakellistatin 12 (1) is a new cancer cell growth inhibitory (P388 ED 50 2.8 microg/mL) cyclodecapeptide that was isolated from a marine sponge Phakellia sp. The first total synthesis of compound 1 is reported here using solid-phase methodology with safety-catch linker strategy. For the sequence of amino acids in the cycle, the peptide product was analyzed with a MALDI TOF/TOF instrument, and the structure of the synthetic product was found to be chemically and spectroscopically identical to the natural substance.

Topics: Animals; Antineoplastic Agents; Leukemia P388; Mice; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Peptides, Cyclic; Porifera

2008