| ID Source | ID |
|---|---|
| PubMed CID | 9039 |
| SCHEMBL ID | 97701 |
| MeSH ID | M0071301 |
| Synonym |
|---|
| ai3-29547 |
| methylphosphorothioate((meo)2(mes)po) |
| o,o,s-trimethylphosphorothioate |
| hc7901 |
| 8000 bis hc |
| ccris 5621 |
| o,o,s-trimethyl phosphorothioate |
| brn 1702881 |
| trimethyl phosphorothioate |
| phosphorothioic acid, o,o,s-trimethyl ester |
| dimethylthiomethylphosphate |
| [methoxy(methylsulfanyl)phosphoryl]oxymethane |
| 152-20-5 |
| AKOS006229643 |
| phosphorothioic acid,o,o,s-trimethyl ester |
| o,o-dimethyl s-methyl thiophosphate |
| CS-B0130 |
| SCHEMBL97701 |
| o,o,s-trimethyl thiophosphate # |
| methyl phosphorothioate ((meo)2(mes)po) |
| hc 7901 |
| WTUNGUOZHBRADH-UHFFFAOYSA-N |
| o,o-dimethyl s-methyl phosphorothioate |
| DTXSID90164928 |
| AS-65608 |
| o,o,s-trimethylphosphorthioate; [methoxy(methylsulfanyl)phosphoryl]oxymethane |
| o,o,s-trimethylthiophosphate |
| J4HYB2U9FX |
| hc-7901 |
| FT-0714242 |
| dimethyl (methylsulfanyl)phosphonate |
| o,o,s-trimethylthiophosphate 100 microg/ml in acetonitrile |
| o,o,s-trimethyl ester phosphorothioic acid |
| thiophosphoric acid o,o',s-trimethyl ester |
| Excerpt | Reference | Relevance |
|---|---|---|
| " Histopathological examinations revealed that OOS-DMEP induced pulmonary oedema and bleeding at a dose of 1/2 LD50 by 72 hr after dosing while the other two compounds did not." | ( Structure and pulmonary toxicity relationship on O,O-dimethyl S-alkyl phosphorothioate esters. Abe, N; Hasegawa, J; Kamiyama, S; Koizumi, A; Sageshima, M; Suzuki, M; Wada, Y, 1990) | 0.28 |
| Excerpt | Relevance | Reference |
|---|---|---|
| " The mortality pattern in rats dosed with OOS-DMEP was similar to the "delayed death" pattern: the LD50s in rats for OOS-DMEP decreased dramatically from more than 200 mg/kg within 24 hr to 41." | ( Structure and pulmonary toxicity relationship on O,O-dimethyl S-alkyl phosphorothioate esters. Abe, N; Hasegawa, J; Kamiyama, S; Koizumi, A; Sageshima, M; Suzuki, M; Wada, Y, 1990) | 0.28 |
| " Mean DSPC content was significantly lower in fetuses from dams dosed at 7 or 20 mg/kg while mean glycogen concentration, in contrast, was 3- to 6-fold higher in those fetuses than fetuses from control or pair-fed dams." | ( Immature alveolar/blood barrier and low disaturated phosphatidylcholine in fetal lung after intrauterine exposure to O,O,S-trimethylphosphorothioate. Higuchi, S; Koizumi, A; Narita, S; Sageshima, M; Wada, Y, 1989) | 0.28 |
| " The cross-fostering did not affect mortality of neonates from either dosed dams or from control dams." | ( Neonatal death and lung injury in rats caused by intrauterine exposure to O,O,S-trimethylphosphorothioate. Hasegawa, L; Imamura, T; Koizumi, A; Montalbo, M; Nguyen, O, 1988) | 0.27 |
| " Treatment with NG-nitro-L-arginine-methyl ester at 20 mg/kg/day aggravated lung injury induced by O,O,S-trimethyl phosphorothioate: Pulmonary oedema and bleeding occurred, leading to an increase in mortalities at 15 mg/kg of O,O,S-trimethyl phosphorothioate, at which level it did not induce such changes as when dosed alone." | ( O,O,S-trimethyl phosphorothioate increases Ca2+ independent nitric oxide synthase activity in the lung but decreases Ca2+/calmodulin dependent type in the cerebellum in Fischer 344 rats. Hamade, N; Koizumi, A; Ohtaka, K; Suzuki, M; Wada, Y; Yamazaki, Y, ) | 1.79 |
| " Animals (five per group) were dosed with OOS-TMP at 40 mg/kg and sacrificed on the 1st, 3rd or 7th day after treatment." | ( Enhanced levels of lipid peroxidation and xanthine oxidase activity in the lung of male Sprague-Dawley rats following treatment with O,O,S-trimethyl phosphorothioate. Koizumi, A; Ohtaka, K, ) | 0.34 |
| "The O-dealkylation of pentoxyresorufin, a substrate for P450 2B1, was decreased in lung microsomes from rats dosed with O,O,S-trimethylphosphorodithioate, O,O,O-trimethylphosphorothioate, bromophos, fenitrothion, p-xylene and 2,4-dichloro-(6-phenylphonoxy)ethylamine." | ( Inhibition and induction of cytochrome P450 isoenzymes in rat lung. Dinsdale, D; Verschoyle, RD; Wolf, CR, 1993) | 0.29 |
| "This study was designed to test the hypothesis that the reduction in cytochrome P450 (CYP) 2B1 content and activity of rat lung microsomes, following dosing with pneumotoxic trimethylphosphorothioates, results from damage to specific cell types." | ( Cell-specific loss of cytochrome P450 2B1 in rat lung following treatment with pneumotoxic and non-pneumotoxic trialkylphosphorothioates. Dinsdale, D; Verschoyle, RD, 2001) | 0.31 |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 32 (76.19) | 18.7374 |
| 1990's | 7 (16.67) | 18.2507 |
| 2000's | 3 (7.14) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (10.15) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 48 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||