n-4-hydroxy-2'-deoxycytidylic acid has been researched along with fluorodeoxyuridylate in 4 studies
| Studies (n-4-hydroxy-2'-deoxycytidylic acid) | Trials (n-4-hydroxy-2'-deoxycytidylic acid) | Recent Studies (post-2010) (n-4-hydroxy-2'-deoxycytidylic acid) | Studies (fluorodeoxyuridylate) | Trials (fluorodeoxyuridylate) | Recent Studies (post-2010) (fluorodeoxyuridylate) |
|---|---|---|---|---|---|
| 6 | 0 | 2 | 348 | 6 | 24 |
| Protein | Taxonomy | n-4-hydroxy-2'-deoxycytidylic acid (IC50) | fluorodeoxyuridylate (IC50) |
|---|---|---|---|
| Thymidylate synthase | Mus musculus (house mouse) | 0.0223 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bretner, M; Cieśla, J; Dzik, JM; Felczak, K; Gołos, B; Kulikowski, T; Miazga, A; Poznański, J; Rode, W; Zieliński, Z | 1 |
| Bretner, M; Cieśla, J; Dzik, JM; Kierdaszuk, B; Kulikowski, T; Rode, W; Shugar, D; Zieliński, Z | 1 |
| Adamowicz, L; Leś, A; Rode, W | 1 |
| Casamayou-Boucau, Y; Cieśla, J; Fita, P; Gordon, F; Jarmuła, A; Maj, P; Prokopowicz, M; Rode, W; Ryder, A; Sobich, J; Zieliński, Z | 1 |
4 other study(ies) available for n-4-hydroxy-2'-deoxycytidylic acid and fluorodeoxyuridylate
| Article | Year |
|---|---|
5-Substituted N(4)-hydroxy-2'-deoxycytidines and their 5'-monophosphates: synthesis, conformation, interaction with tumor thymidylate synthase, and in vitro antitumor activity.
Topics: Animals; Antineoplastic Agents; Bromodeoxyuridine; Catalysis; Cell Division; Deoxycytidine; Deoxycytidine Monophosphate; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Idoxuridine; Kinetics; Mice; Molecular Conformation; Stereoisomerism; Structure-Activity Relationship; Thymidylate Synthase; Tumor Cells, Cultured | 2000 |
Mechanism of inhibition of mammalian tumor and other thymidylate synthases by N4-hydroxy-dCMP, N4-hydroxy-5-fluoro-dCMP, and related analogues.
Topics: Animals; Binding Sites; Binding, Competitive; Carcinoma, Ehrlich Tumor; Deoxycytidine Monophosphate; Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Hymenolepis; Kinetics; Leukemia L1210; Liver; Liver Regeneration; Mice; Neoplasms, Experimental; Rats; Thymidylate Synthase; Tumor Cells, Cultured | 1990 |
Modeling of reaction steps relevant to deoxyuridylate (dUMP) enzymatic methylation and thymidylate synthase mechanism-based inhibition.
Topics: Algorithms; Cysteine; Deoxycytidine Monophosphate; Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Methylation; Models, Chemical; Quantum Theory; Sulfhydryl Compounds; Tetrahydrofolates; Thymidylate Synthase; Uracil; Water | 1998 |
Advanced Spectroscopy and APBS Modeling for Determination of the Role of His190 and Trp103 in Mouse Thymidylate Synthase Interaction with Selected dUMP Analogues.
Topics: Amino Acid Substitution; Animals; Deoxycytidine Monophosphate; Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Mice; Models, Molecular; Models, Theoretical; Multivariate Analysis; Protein Conformation; Spectrometry, Fluorescence; Static Electricity; Thymidylate Synthase | 2021 |