Compounds > korupensamine-b
Page last updated: 2024-11-08

korupensamine-b

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

korupensamine A: from Ancistrocladus and triphyophyllum; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID392421
CHEMBL ID487392
CHEBI ID31754
SCHEMBL ID1230082
MeSH IDM0286835

Synonyms (20)

Synonym
nsc692899
nsc-692899
korupensamine a
158182-18-4
korupensamine b
CHEMBL487392 ,
chebi:31754 ,
(1r,3r)-5-(4-hydroxy-5-methoxy-7-methylnaphthalen-1-yl)-1,3-dimethyl-1,2,3,4-tetrahydroisoquinoline-6,8-diol
AC1L9432 ,
5-(4-hydroxy-5-methoxy-7-methylnaphthalen-1-yl)-1,3-dimethyl-1,2,3,4-tetrahydroisoquinoline-6,8-diol
AC1Q2QQ8 ,
158252-04-1
6,8-isoquinolinediol, 1,2,3,4-tetrahydro-5-(4-hydroxy-5-methoxy-7-methyl-1-naphthalenyl)-1,3-dimethyl-, (1r,3r,5r)-
6,8-isoquinolinediol, 1,2,3,4-tetrahydro-5-(4-hydroxy-5-methoxy-7-methyl-1-naphthalenyl)-1,3-dimethyl-, (1r,3r,5s)-
(-)-korupensamine a
SCHEMBL1230082
surecn1230082
(1r,3r)-5-(4-hydroxy-5-methoxy-7-methyl-1-naphthyl)-1,3-dimethyl-1,2,3,4-tetrahydroisoquinoline-6,8-diol
DTXSID50935873
Q27114680
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (2)

ClassDescription
isoquinolinesA class of organic heteropolycyclic compound consisting of isoquinoline and its substitution derivatives.
naphthalenesAny benzenoid aromatic compound having a skeleton composed of two ortho-fused benzene rings.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (9)

Assay IDTitleYearJournalArticle
AID335552Antileishmanial activity against Leishmania donovani2002Journal of natural products, Aug, Volume: 65, Issue:8
Ancistrocongolines A-D, new naphthylisoquinoline alkaloids from ancistrocladus congolensis.
AID335553Cytotoxicity against rat L6 cells after 72 hrs by alamar blue assay2002Journal of natural products, Aug, Volume: 65, Issue:8
Ancistrocongolines A-D, new naphthylisoquinoline alkaloids from ancistrocladus congolensis.
AID335551Antitrypanosomal activity against Trypanosoma brucei rhodesiense after 72 hrs by alamar blue assay2002Journal of natural products, Aug, Volume: 65, Issue:8
Ancistrocongolines A-D, new naphthylisoquinoline alkaloids from ancistrocladus congolensis.
AID335550Antitrypanosomal activity against Trypanosoma cruzi Tulahuen strain C2C4 containing galactosidase gene in rat L6 cells after 4 days2002Journal of natural products, Aug, Volume: 65, Issue:8
Ancistrocongolines A-D, new naphthylisoquinoline alkaloids from ancistrocladus congolensis.
AID377569Cytotoxicity against rat L6 cells after 72 hrs2000Journal of natural products, Oct, Volume: 63, Issue:10
Ancistrolikokines A-C: new 5,8'-coupled naphthylisoquinoline alkaloids from Ancistrocladus likoko.
AID335549Antimalarial activity against Plasmodium falciparum K1 in human erythrocytes after 48 hrs by [3H]hypoxanthine uptake2002Journal of natural products, Aug, Volume: 65, Issue:8
Ancistrocongolines A-D, new naphthylisoquinoline alkaloids from ancistrocladus congolensis.
AID377567Antimalarial activity after 48 hrs against Plasmodium falciparum NF54 infected human erythrocytes by [3H]hypoxanthine uptake2000Journal of natural products, Oct, Volume: 63, Issue:10
Ancistrolikokines A-C: new 5,8'-coupled naphthylisoquinoline alkaloids from Ancistrocladus likoko.
AID377568Antimalarial activity after 48 hrs against Plasmodium falciparum K1 infected human erythrocytes by [3H]hypoxanthine uptake2000Journal of natural products, Oct, Volume: 63, Issue:10
Ancistrolikokines A-C: new 5,8'-coupled naphthylisoquinoline alkaloids from Ancistrocladus likoko.
AID1410125Antiplasmodial activity against Plasmodium falciparum NF542018Journal of natural products, 04-27, Volume: 81, Issue:4
Mbandakamine-Type Naphthylisoquinoline Dimers and Related Alkaloids from the Central African Liana Ancistrocladus ealaensis with Antiparasitic and Antileukemic Activities.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (11.11)18.2507
2000's4 (44.44)29.6817
2010's3 (33.33)24.3611
2020's1 (11.11)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other9 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
chloroquine
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.. chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.		2.4520aminoquinoline;
organochlorine compound;
secondary amino compound;
tertiary amino compound		anticoronaviral agent;
antimalarial;
antirheumatic drug;
autophagy inhibitor;
dermatologic drug
miltefosine
miltefosine: hexadecyl phosphocholine derivative of cisplatin; did not substantially activate HIV long terminal repeat; less toxic than cisplatin. miltefosine : A phospholipid that is the hexadecyl monoester of phosphocholine.		2.1710phosphocholines;
phospholipid		anti-inflammatory agent;
anticoronaviral agent;
antifungal agent;
antineoplastic agent;
antiprotozoal drug;
apoptosis inducer;
immunomodulator;
protein kinase inhibitor
melarsoprol
Melarsoprol: Arsenical used in trypanosomiases. It may cause fatal encephalopathy and other undesirable side effects.		2.4620triazines
podophyllotoxin
Podophyllum: A genus of poisonous American herbs, family BERBERIDACEAE. The roots yield PODOPHYLLOTOXIN and other pharmacologically important agents. The plant was formerly used as a cholagogue and cathartic. It is different from the European mandrake, MANDRAGORA.		2.1710furonaphthodioxole;
lignan;
organic heterotetracyclic compound		antimitotic;
antineoplastic agent;
keratolytic drug;
microtubule-destabilising agent;
plant metabolite;
tubulin modulator
palladium
Palladium: A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.. palladium : Chemical element (nickel group element atom) with atomic number 46.		210metal allergen;
nickel group element atom;
platinum group metal atom
benzonidazole
benzonidazole: used in treatment of Chagas' disease. benznidazole : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2-nitroimidazol-1-yl)acetic acid with the aromatic amino group of benzylamine. Used for treatment of Chagas disease.		2.4620C-nitro compound;
imidazoles;
monocarboxylic acid amide		antiprotozoal drug
michellamine c
michellamine A: atropisomeric naphthylisoquinoline anti-HIV cytopathic alkaloid dimers; from tropical plant Ancistrocladus abbreviatus; structure given in first source. michellamine A : A dimeric isoquinoline alkaloid isolated from Ancistrocladus abbreviatus and has been shown to exhibit anti-HIV activity.		2.4320
ConditionIndicatedRelationship StrengthStudiesTrials
2019 Novel Coronavirus Disease
[description not available]		02.610