Page last updated: 2024-12-08
korupensamine-b
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Description
korupensamine A: from Ancistrocladus and triphyophyllum; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 392421 |
| CHEMBL ID | 487392 |
| CHEBI ID | 31754 |
| SCHEMBL ID | 1230082 |
| MeSH ID | M0286835 |
Synonyms (20)
| Synonym |
|---|
| nsc692899 |
| nsc-692899 |
| korupensamine a |
| 158182-18-4 |
| korupensamine b |
| CHEMBL487392 , |
| chebi:31754 , |
| (1r,3r)-5-(4-hydroxy-5-methoxy-7-methylnaphthalen-1-yl)-1,3-dimethyl-1,2,3,4-tetrahydroisoquinoline-6,8-diol |
| AC1L9432 , |
| 5-(4-hydroxy-5-methoxy-7-methylnaphthalen-1-yl)-1,3-dimethyl-1,2,3,4-tetrahydroisoquinoline-6,8-diol |
| AC1Q2QQ8 , |
| 158252-04-1 |
| 6,8-isoquinolinediol, 1,2,3,4-tetrahydro-5-(4-hydroxy-5-methoxy-7-methyl-1-naphthalenyl)-1,3-dimethyl-, (1r,3r,5r)- |
| 6,8-isoquinolinediol, 1,2,3,4-tetrahydro-5-(4-hydroxy-5-methoxy-7-methyl-1-naphthalenyl)-1,3-dimethyl-, (1r,3r,5s)- |
| (-)-korupensamine a |
| SCHEMBL1230082 |
| surecn1230082 |
| (1r,3r)-5-(4-hydroxy-5-methoxy-7-methyl-1-naphthyl)-1,3-dimethyl-1,2,3,4-tetrahydroisoquinoline-6,8-diol |
| DTXSID50935873 |
| Q27114680 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Drug Classes (2)
| Class | Description |
|---|---|
| isoquinolines | A class of organic heteropolycyclic compound consisting of isoquinoline and its substitution derivatives. |
| naphthalenes | Any benzenoid aromatic compound having a skeleton composed of two ortho-fused benzene rings. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
Bioassays (9)
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID335552 | Antileishmanial activity against Leishmania donovani | 2002 | Journal of natural products, Aug, Volume: 65, Issue:8 | Ancistrocongolines A-D, new naphthylisoquinoline alkaloids from ancistrocladus congolensis. |
| AID335553 | Cytotoxicity against rat L6 cells after 72 hrs by alamar blue assay | 2002 | Journal of natural products, Aug, Volume: 65, Issue:8 | Ancistrocongolines A-D, new naphthylisoquinoline alkaloids from ancistrocladus congolensis. |
| AID335551 | Antitrypanosomal activity against Trypanosoma brucei rhodesiense after 72 hrs by alamar blue assay | 2002 | Journal of natural products, Aug, Volume: 65, Issue:8 | Ancistrocongolines A-D, new naphthylisoquinoline alkaloids from ancistrocladus congolensis. |
| AID335550 | Antitrypanosomal activity against Trypanosoma cruzi Tulahuen strain C2C4 containing galactosidase gene in rat L6 cells after 4 days | 2002 | Journal of natural products, Aug, Volume: 65, Issue:8 | Ancistrocongolines A-D, new naphthylisoquinoline alkaloids from ancistrocladus congolensis. |
| AID377569 | Cytotoxicity against rat L6 cells after 72 hrs | 2000 | Journal of natural products, Oct, Volume: 63, Issue:10 | Ancistrolikokines A-C: new 5,8'-coupled naphthylisoquinoline alkaloids from Ancistrocladus likoko. |
| AID335549 | Antimalarial activity against Plasmodium falciparum K1 in human erythrocytes after 48 hrs by [3H]hypoxanthine uptake | 2002 | Journal of natural products, Aug, Volume: 65, Issue:8 | Ancistrocongolines A-D, new naphthylisoquinoline alkaloids from ancistrocladus congolensis. |
| AID377567 | Antimalarial activity after 48 hrs against Plasmodium falciparum NF54 infected human erythrocytes by [3H]hypoxanthine uptake | 2000 | Journal of natural products, Oct, Volume: 63, Issue:10 | Ancistrolikokines A-C: new 5,8'-coupled naphthylisoquinoline alkaloids from Ancistrocladus likoko. |
| AID377568 | Antimalarial activity after 48 hrs against Plasmodium falciparum K1 infected human erythrocytes by [3H]hypoxanthine uptake | 2000 | Journal of natural products, Oct, Volume: 63, Issue:10 | Ancistrolikokines A-C: new 5,8'-coupled naphthylisoquinoline alkaloids from Ancistrocladus likoko. |
| AID1410125 | Antiplasmodial activity against Plasmodium falciparum NF54 | 2018 | Journal of natural products, 04-27, Volume: 81, Issue:4 | Mbandakamine-Type Naphthylisoquinoline Dimers and Related Alkaloids from the Central African Liana Ancistrocladus ealaensis with Antiparasitic and Antileukemic Activities. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
Research
Studies (9)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 4 (44.44) | 29.6817 |
| 2010's | 3 (33.33) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 9 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||