Page last updated: 2024-12-08
homoegonol
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Description
homoegonol: has anti-asthmatic activity; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 176929 |
| CHEMBL ID | 3634694 |
| SCHEMBL ID | 15258226 |
| MeSH ID | M000605370 |
Synonyms (15)
| Synonym |
|---|
| 3-[2-(3,4-dimethoxyphenyl)-7-methoxy-benzofuran-5-yl]propan-1-ol |
| 5-(3''-hydroxypropyl)-7-methoxy-2-(3',4'-dimethoxyphenyl)benzofuran |
| homoegonol |
| 3-[2-(3,4-dimethoxyphenyl)-7-methoxy-1-benzofuran-5-yl]propan-1-ol |
| FT-0669223 |
| 17375-66-5 |
| 2-(3,4-dimethoxyphenyl)-5-(3-hydroxypropyl)-7-methoxybenzofuran |
| SCHEMBL15258226 |
| 3-[2-(3,4-dimethoxyphenyl)-7-methoxy-1-benzofuran-5-yl]-1-propanol # |
| 5-benzofuranpropanol, 2-(3,4-dimethoxyphenyl)-7-methoxy- |
| PFOARMALXZGCHY-UHFFFAOYSA-N |
| CHEMBL3634694 |
| DTXSID50169651 |
| 3-(2-(3,4-dimethoxyphenyl)-7-methoxybenzofuran-5-yl)propan-1-ol |
| 3-[2-(3,4-dimethoxyphenyl)-7-methoxybenzofuran-5-yl]-1-propanol |
Research Excerpts
Overview
Homoegonol is a lignan derived from styraxlignolide A. It was isolated from Styrax japonica, a medicinal plant widely used for treatment of inflammatory diseases.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Homoegonol is a lignan derived from styraxlignolide A, which was isolated from Styrax japonica, a medicinal plant widely used for treatment of inflammatory diseases in Korea. " | ( Homoegonol attenuates the asthmatic responses induced by ovalbumin challenge. Ahn, KS; Chin, YW; Jeon, CM; Kwon, OK; Lee, K; Oh, SR; Shin, IS; Shin, NR, 2014) | 3.29 |
Treatment
| Excerpt | Reference | Relevance |
|---|---|---|
| "The homoegonol-treated mice exhibited reduced inflammatory cell counts and Th2 cytokines in BALF, AHR, and IgE in the serum compared with the OVA-sensitized/challenged mice." | ( Homoegonol attenuates the asthmatic responses induced by ovalbumin challenge. Ahn, KS; Chin, YW; Jeon, CM; Kwon, OK; Lee, K; Oh, SR; Shin, IS; Shin, NR, 2014) | 2.33 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Bioassays (6)
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1498471 | Cytotoxicity against human CEM/ADR5000 cells over-expressing P-gp assessed as reduction in cell viability after 72 hrs by resazurin dye based assay | 2018 | Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12 | Access to new highly potent antileukemia, antiviral and antimalarial agents via hybridization of natural products (homo)egonol, thymoquinone and artemisinin. |
| AID1498472 | Antimalarial activity against Plasmodium falciparum 3D7 infected in human erythrocytes after 72 hrs by SYBR green dye fluorescence assay | 2018 | Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12 | Access to new highly potent antileukemia, antiviral and antimalarial agents via hybridization of natural products (homo)egonol, thymoquinone and artemisinin. |
| AID1256625 | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production at 3 to 30 ug/ml after 24 hrs by Griess reaction | 2015 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 25, Issue:22 | Inhibitory effects of compounds from Styrax obassia on NO production. |
| AID1256626 | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production at 30 ug/ml after 24 hrs by Griess reaction | 2015 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 25, Issue:22 | Inhibitory effects of compounds from Styrax obassia on NO production. |
| AID1498470 | Cytotoxicity against human CCRF-CEM cells assessed as reduction in cell viability after 72 hrs by resazurin dye based assay | 2018 | Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12 | Access to new highly potent antileukemia, antiviral and antimalarial agents via hybridization of natural products (homo)egonol, thymoquinone and artemisinin. |
| AID1498473 | Antiviral activity against GFP-fused Human cytomegalovirus AD169 infected in primary HFF | 2018 | Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12 | Access to new highly potent antileukemia, antiviral and antimalarial agents via hybridization of natural products (homo)egonol, thymoquinone and artemisinin. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
Research
Studies (6)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 4 (66.67) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 6 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||