geographutoxin i profile

gonyautoxin I: structure in first source; RN given refers to gonyautoxin I; gonyantoxin IV is isomer of gonyautoxin I [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

geographutoxin I: toxic peptide from Conus geographus with 22 amino acids; different from conotoxin GI; amino acid sequence given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	104848
SCHEMBL ID	22319914
MeSH ID	M0114839
PubMed CID	56843427
CHEMBL ID	4562161
MeSH ID	M0114839

Synonym
gonyautoxin i
gtx i
SCHEMBL22319914
geographutoxin i
mu-conotoxin giiia
86394-16-3
mu-conotoxin g iiia (reduced)
.mu.-conotoxin g iiia
conotoxin g iiia
mu-conotoxin g iiia
129129-65-3
unii-0c5t02ki0e
l-alaninamide, l-arginyl-l-alpha-aspartyl-l-cysteinyl-l-cysteinyl-l-threonyl-(4r)-4-hydroxy-l-prolyl-(4r)-4-hydroxy-l-prolyl-l-lysyl-l-lysyl-l-cysteinyl-l-lysyl-l-alpha-aspartyl-l-arginyl-l-glutaminyl-l-cysteinyl-l-lysyl-(4r)-4-hydroxy-l-prolyl-l
0c5t02ki0e ,
bdbm50520482
CHEMBL4562161 ,
DTXSID101339126

Excerpt	Reference	Relevance
" Therefore, populations utilizing high ammonium concentration could be more toxic than those growing on nitrate or urea."	( Variability in toxicity of the dinoflagellate Alexandrium tamarense in response to different nitrogen sources and concentrations. Leong, SC; Murata, A; Nagashima, Y; Taguchi, S, 2004)	0.32

Role	Description
marine metabolite	Any metabolite produced during a metabolic reaction in marine macro- and microorganisms.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Class	Description
organic heterotricyclic compound	An organic tricyclic compound in which at least one of the rings of the tricyclic skeleton contains one or more heteroatoms.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Sodium channel protein type 4 subunit alpha	Rattus norvegicus (Norway rat)	IC50 (µMol)	0.0690	0.0690	0.2845	0.5000	AID1583525
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Assay ID	Title	Year	Journal	Article
AID1583525	Inhibition of rat Nav1.4 expressed in HEK293 cells at -80 mV holding potential by whole cell patch-clamp assay	2020	Journal of medicinal chemistry, 02-27, Volume: 63, Issue:4	Structure and Activity Studies of Disulfide-Deficient Analogues of αO-Conotoxin GeXIVA.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	3 (18.75)	18.7374
1990's	3 (18.75)	18.2507
2000's	3 (18.75)	29.6817
2010's	6 (37.50)	24.3611
2020's	1 (6.25)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Trials	0 (0.00%)	5.53%
Reviews	1 (10.00%)	6.00%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Observational	0 (0.00%)	0.25%
Other	9 (90.00%)	84.16%
Other	6 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
nitrates Nitrates: Inorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical.	2.02	1	monovalent inorganic anion; nitrogen oxoanion; reactive nitrogen species
urea pseudourea: clinical use; structure. isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.	2.02	1	isourea; monocarboxylic acid amide; one-carbon compound	Daphnia magna metabolite; Escherichia coli metabolite; fertilizer; flour treatment agent; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
lidocaine Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.. lidocaine : The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.	2.06	1	benzenes; monocarboxylic acid amide; tertiary amino compound	anti-arrhythmia drug; drug allergen; environmental contaminant; local anaesthetic; xenobiotic
phentolamine Phentolamine: A nonselective alpha-adrenergic antagonist. It is used in the treatment of hypertension and hypertensive emergencies, pheochromocytoma, vasospasm of RAYNAUD DISEASE and frostbite, clonidine withdrawal syndrome, impotence, and peripheral vascular disease.. phentolamine : A substituted aniline that is 3-aminophenol in which the hydrogens of the amino group are replaced by 4-methylphenyl and 4,5-dihydro-1H-imidazol-2-ylmethyl groups respectively. An alpha-adrenergic antagonist, it is used for the treatment of hypertension.	2.06	1	imidazoles; phenols; substituted aniline; tertiary amino compound	alpha-adrenergic antagonist; vasodilator agent
tetrodotoxin Tetrodotoxin: An aminoperhydroquinazoline poison found mainly in the liver and ovaries of fishes in the order TETRAODONTIFORMES, which are eaten. The toxin causes paresthesia and paralysis through interference with neuromuscular conduction.. tetrodotoxin : A quinazoline alkaloid that is a marine toxin isolated from fish such as puffer fish. It has been shown to exhibit potential neutotoxicity due to its ability to block voltage-gated sodium channels.	2.06	1	azatetracycloalkane; oxatetracycloalkane; quinazoline alkaloid	animal metabolite; bacterial metabolite; marine metabolite; neurotoxin; voltage-gated sodium channel blocker
brevetoxin b brevetoxin B: from dinoflagellate Gymnodinium breve	2.06	1	ciguatoxin
gonyautoxin v gonyautoxin V: structure in first source	3.06	1	organic heterotricyclic compound; paralytic shellfish toxin	marine metabolite
saxitoxin Saxitoxin: A compound that contains a reduced purine ring system but is not biosynthetically related to the purine alkaloids. It is a poison found in certain edible mollusks at certain times; elaborated by GONYAULAX and consumed by mollusks, fishes, etc. without ill effects. It is neurotoxic and causes RESPIRATORY PARALYSIS and other effects in MAMMALS, known as paralytic SHELLFISH poisoning.. saxitoxin : An alkaloid isolated from the marine dinoflagellates and cyanobacteria that causes paralytic shellfish poisoning.	4.85	10	alkaloid; carbamate ester; guanidines; ketone hydrate; paralytic shellfish toxin; pyrrolopurine	cyanotoxin; marine metabolite; neurotoxin; sodium channel blocker; toxin
gonyautoxin ii gonyautoxin II: RN given refers to (3aS-(3aalpha,4alpha,9beta,10aR*))-isomer; gonyautoxin III is the (9alpha)-isomer of gonyautoxin II	3.46	7	organic heterotricyclic compound; paralytic shellfish toxin	marine metabolite
hydroxyproline Hydroxyproline: A hydroxylated form of the imino acid proline. A deficiency in ASCORBIC ACID can result in impaired hydroxyproline formation.. hydroxyproline : A proline derivative that is proline substituted by at least one hydroxy group.	1.96	1	4-hydroxyproline; L-alpha-amino acid zwitterion	human metabolite; mouse metabolite; plant metabolite
saxitoxin Saxitoxin: A compound that contains a reduced purine ring system but is not biosynthetically related to the purine alkaloids. It is a poison found in certain edible mollusks at certain times; elaborated by GONYAULAX and consumed by mollusks, fishes, etc. without ill effects. It is neurotoxic and causes RESPIRATORY PARALYSIS and other effects in MAMMALS, known as paralytic SHELLFISH poisoning.. saxitoxin : An alkaloid isolated from the marine dinoflagellates and cyanobacteria that causes paralytic shellfish poisoning.	2	1	alkaloid; carbamate ester; guanidines; ketone hydrate; paralytic shellfish toxin; pyrrolopurine	cyanotoxin; marine metabolite; neurotoxin; sodium channel blocker; toxin
geographutoxin ii geographutoxin II: toxic peptide from Conus geographus with 22 amino acids; different from conotoxin GI; amino acid sequence given in first source	2.36	2

Condition	Relationship Strength	Studies
Amnesic Shellfish Poisoning A condition caused by ingestion of shellfish contaminated by domoic acid-producing diatoms of the genus Pseudo-nitzschia.	2.99	4
Palsy [description not available]	2.88	1
Paralysis A general term most often used to describe severe or complete loss of muscle strength due to motor system disease from the level of the cerebral cortex to the muscle fiber. This term may also occasionally refer to a loss of sensory function. (From Adams et al., Principles of Neurology, 6th ed, p45)	2.88	1
Muscle Contraction A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.	1.96	1

geographutoxin i

Description

Cross-References

Synonyms (17)

Research Excerpts

Toxicity

Roles (1)

Drug Classes (1)

Protein Targets (1)

Inhibition Measurements

Bioassays (1)

Research

Studies (16)

Market Indicators

Research Demand Index: 12.63

Study Types