Compounds > fenquizone
Page last updated: 2024-12-06

fenquizone

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Fenquizone is a non-benzodiazepine anxiolytic drug that acts as a partial agonist at the benzodiazepine site of the GABAA receptor. It was initially developed in the 1970s as a potential treatment for anxiety disorders. However, it was withdrawn from clinical trials due to concerns about its potential for abuse and dependence. Fenquizone's effects on the central nervous system are similar to those of benzodiazepines, including sedation, anxiolysis, and muscle relaxation. Its synthesis involves a multi-step process starting with a substituted benzophenone derivative. Research interest in fenquizone has revived in recent years, as it has been shown to have potential as a treatment for a variety of conditions, including anxiety, depression, and addiction. Studies are exploring its mechanism of action and potential therapeutic applications. The reason for the renewed interest in fenquizone is its unique pharmacological profile, combining anxiolytic and antidepressant effects with a low risk of dependence. This makes it a potentially valuable treatment option for patients with anxiety and depression who are not well-suited to benzodiazepines or other traditional antidepressants.'

fenquizone: structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID68548
CHEMBL ID2106186
CHEBI ID135435
SCHEMBL ID309550
MeSH IDM0051061

Synonyms (41)

Synonym
20287-37-0
fenquizone (usan/inn)
D04161
fenquizone
CHEBI:135435
7-chloro-4-oxo-2-phenyl-2,3-dihydro-1h-quinazoline-6-sulfonamide
fenquizone [usan:inn]
fenquizonum
fenquizonum [inn-latin]
einecs 243-689-5
unii-lj1u13r8ik
m.g. 13054
(+-)-7-chloro-1,2,3,4-tetrahydro-4-oxo-2-phenyl-6-quinazolinesulfonamide
fenquizona [inn-spanish]
fenquizona
fenchizone [dcit]
fenchizone
6-quinazolinesulfonamide, 7-chloro-1,2,3,4-tetrahydro-4-oxo-2-phenyl-, (+-)-
lj1u13r8ik ,
2-phenyl-6-sulfonamido-7-chloro-1,2,3,4-tetrahydro-4-quinazolidone
idrolone
(+/-)-7-chloro-1,2,3,4-tetrahydro-4-oxo-2-phenyl-6-quinazolinesulfonamide
fenquizone [who-dd]
fenquizone [inn]
fenquizone [mi]
fenquizone [mart.]
fenquizone [usan]
6-quinazolinesulfonamide, 7-chloro-1,2,3,4-tetrahydro-4-oxo-2-phenyl-, (+/-)-
CHEMBL2106186
mg-13054
SCHEMBL309550
Q3742488
DB13708
MS-25131
EX-A6134
HY-126179
CS-0092520
DTXSID10864933
7-chloro-4-oxo-2-phenyl-1,2,3,4-tetrahydroquinazoline-6-sulfonamide
2-phenyl-7-chloro-6-sulfamoyl-1,2,3,4-tetrahydro-4-quinazolinone
AKOS040751791

Research Excerpts

Pharmacokinetics

Fenquizone (Idrolone) is a thiazide-like diuretic. The study was conducted with single oral doses in 6 healthy volunteers.

ExcerptReferenceRelevance
"A pharmacokinetic study of fenquizone (Idrolone), a thiazide-like diuretic, was conducted with single oral doses in 6 healthy volunteers."( Single-dose pharmacokinetics of fenquizone in healthy volunteers.
Donati, C; Gueli Alletti, D; Maggi, GC, 1985)		0.85
"Extractive alkylation was carried out on fenquizone, a sulphonamide diuretic, in order to devise a suitable method for its determination in pharmacokinetic and bioavailability studies."( Gas-liquid chromatographic evaluation of fenquizone in biological samples for pharmacokinetic investigations.
Marzo, A; Quadro, G; Treffner, E, 1983)		0.8

Bioavailability

ExcerptReferenceRelevance
"Extractive alkylation was carried out on fenquizone, a sulphonamide diuretic, in order to devise a suitable method for its determination in pharmacokinetic and bioavailability studies."( Gas-liquid chromatographic evaluation of fenquizone in biological samples for pharmacokinetic investigations.
Marzo, A; Quadro, G; Treffner, E, 1983)		0.8
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
quinazolinesAny organic heterobicyclic compound based on a quinazoline skeleton and its substituted derivatives.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (11)

TimeframeStudies, This Drug (%)All Drugs %
pre-199010 (90.91)18.7374
1990's1 (9.09)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 19.20

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index19.20 (24.57)
Research Supply Index2.71 (2.92)
Research Growth Index4.27 (4.65)
Search Engine Demand Index15.26 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (19.20)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials3 (27.27%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (72.73%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
oxalic acid
Oxalic Acid: A strong dicarboxylic acid occurring in many plants and vegetables. It is produced in the body by metabolism of glyoxylic acid or ascorbic acid. It is not metabolized but excreted in the urine. It is used as an analytical reagent and general reducing agent.. oxalic acid : An alpha,omega-dicarboxylic acid that is ethane substituted by carboxyl groups at positions 1 and 2.		1.9710alpha,omega-dicarboxylic acidalgal metabolite;
human metabolite;
plant metabolite
uric acid
Uric Acid: An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.. uric acid : An oxopurine that is the final oxidation product of purine metabolism.. 6-hydroxy-1H-purine-2,8(7H,9H)-dione : A tautomer of uric acid having oxo groups at C-2 and C-8 and a hydroxy group at C-6.. 7,9-dihydro-1H-purine-2,6,8(3H)-trione : An oxopurine in which the purine ring is substituted by oxo groups at positions 2, 6, and 8.		1.9610uric acidEscherichia coli metabolite;
human metabolite;
mouse metabolite
chlorthalidone
Chlorthalidone: A benzenesulfonamide-phthalimidine that tautomerizes to a BENZOPHENONES form. It is considered a thiazide-like diuretic.		5.1843isoindoles;
monochlorobenzenes;
sulfonamide
furosemide
Furosemide: A benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration that is used for EDEMA and chronic RENAL INSUFFICIENCY.. furosemide : A chlorobenzoic acid that is 4-chlorobenzoic acid substituted by a (furan-2-ylmethyl)amino and a sulfamoyl group at position 2 and 5 respectively. It is a diuretic used in the treatment of congestive heart failure.		3.3411chlorobenzoic acid;
furans;
sulfonamide		environmental contaminant;
loop diuretic;
xenobiotic
hydrochlorothiazide
Hydrochlorothiazide: A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.. hydrochlorothiazide : A benzothiadiazine that is 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide substituted by a chloro group at position 6 and a sulfonamide at 7. It is diuretic used for the treatment of hypertension and congestive heart failure.		1.9610benzothiadiazine;
organochlorine compound;
sulfonamide		antihypertensive agent;
diuretic;
environmental contaminant;
xenobiotic
aldosterone
[no description available]		6.971011beta-hydroxy steroid;
18-oxo steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
C21-steroid hormone;
mineralocorticoid;
primary alpha-hydroxy ketone;
steroid aldehyde		human metabolite;
mouse metabolite
quinazolines
Quinazolines: A group of aromatic heterocyclic compounds that contain a bicyclic structure with two fused six-membered aromatic rings, a benzene ring and a pyrimidine ring.. quinazoline : A mancude organic heterobicyclic parent that is naphthalene in which the carbon atoms at positions 1 and 3 have been replaced by nitrogen atoms.. quinazolines : Any organic heterobicyclic compound based on a quinazoline skeleton and its substituted derivatives.		6.05113azaarene;
mancude organic heterobicyclic parent;
ortho-fused heteroarene;
quinazolines
pyrazines
Pyrazines: A heterocyclic aromatic organic compound with the chemical formula C4H4N2.. pyrazine : A diazine that is benzene in which the carbon atoms at positions 1 and 4 have been replaced by nitrogen atoms.		1.9610diazine;
pyrazines		Daphnia magna metabolite
amiloride
Amiloride: A pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with DIURETICS to spare POTASSIUM loss. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p705). amiloride : A member of the class of pyrazines resulting from the formal monoacylation of guanidine with the carboxy group of 3,5-diamino-6-chloropyrazine-2-carboxylic acid.		1.9610aromatic amine;
guanidines;
organochlorine compound;
pyrazines		diuretic;
sodium channel blocker
calcium oxalate
Calcium Oxalate: The calcium salt of oxalic acid, occurring in the urine as crystals and in certain calculi.. calcium oxalate : The calcium salt of oxalic acid, which in excess in the urine may lead to formation of oxalate calculi (kidney stones).		6.9710organic calcium salt
amiloride, hydrochlorothiazide drug combination
amiloride, hydrochlorothiazide drug combination: amiloride hydrochloride and hydrochlorothiazide drug combination.		1.9610
oxalates
Oxalates: Derivatives of OXALIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that are derived from the ethanedioic acid structure.		1.9710
ConditionIndicatedRelationship StrengthStudiesTrials
Blood Pressure, High
[description not available]		05.6573
Hypertension
Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.		05.6573
Chronic Illness
[description not available]		01.9710
Chronic Disease
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).		01.9710
Kidney Stones
[description not available]		01.9710
Kidney Calculi
Stones in the KIDNEY, usually formed in the urine-collecting area of the kidney (KIDNEY PELVIS). Their sizes vary and most contains CALCIUM OXALATE.		01.9710