Compounds > di-(2-ethylhexyl) terephthalate
Page last updated: 2024-12-06

di-(2-ethylhexyl) terephthalate

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Di-(2-ethylhexyl) terephthalate, commonly known as DEHT, is a plasticizer used in various industries, including polymers, resins, and adhesives. It is synthesized through the esterification of terephthalic acid with 2-ethylhexanol. DEHT is a colorless, odorless liquid with excellent compatibility and low volatility. It is often used to improve the flexibility, workability, and durability of polymers. Studies on DEHT focus on its potential environmental impact, its effect on human health, and its contribution to the overall lifecycle of plastic products. The compound is known to be persistent in the environment and can accumulate in the food chain, raising concerns about its potential toxicity to wildlife and humans. Ongoing research explores alternative plasticizers and sustainable production methods to minimize the environmental burden of DEHT.'
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Cross-References

ID SourceID
PubMed CID22932
CHEMBL ID1871770
SCHEMBL ID110764
MeSH IDM0151022

Synonyms (60)

Synonym
LS-15075
eastman dotp plasticizer
dioctyl terephthalate, ~80%
dioctyl terephthalate, >=96%
NCGC00164195-01
brn 2302822
1,4-benzenedicarboxylic acid, bis(2-ethylhexyl)ester
einecs 229-176-9
hsdb 6150
terephthalic acid, bis(2-ethylhexyl) ester
kodaflex dotp
ai3-17104
di-(2-ethylhexyl) terephthalate
di(2-ethylhexyl) terephthalate
ccris 7052
bis(2-ethylhexyl) terephthalate
1,4-benzenedicarboxylic acid, bis(2-ethylhexyl) ester
6422-86-2
bis(2-ethylhexyl) benzene-1,4-dicarboxylate
NCGC00164195-03
NCGC00164195-02
tox21_300322
NCGC00254126-01
NCGC00258015-01
dtxsid7027625 ,
dtxcid507625
tox21_200461
cas-6422-86-2
1,4-benzenedicarboxylic acid, 1,4-bis(2-ethylhexyl) ester
eastman tm 168
ec 229-176-9
adk cizer d 810
dehtp
unii-4vs908w98l
plasticizer 168
eastman 168
un 488
4vs908w98l ,
palatinol dotp
eastman 168 plasticizer
diethylhexyl terephthalate
bis(2-ethylhexyl) terephthalate [hsdb]
diethylhexyl terephthalate [inci]
(+/-)-bis(2-ethylhexyl) terephthalate
SCHEMBL110764
terephthalic acid bis(2-ethylhexyl) ester
mfcd00072256
CHEMBL1871770
terephthalic acid, bis(2-ethylhexyl)ester
jp 110
RWPICVVBGZBXNA-UHFFFAOYSA-N
AKOS028108403
J-519867
1,4-bis(2-ethylhexyl) benzene-1,4-dicarboxylate
terephthalic acid, bis-2-ethylhexyl ester
bis(2-ethylhexyl) terephthalate, analytical standard
di(2-ethylhexyl)terephthalate
Q5279087
bis(2-ethylhexyl)terephthalate
terephthalic acid, bis-2-ethylhexyl ester 100 microg/ml in acetonitrile

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" Toxic responses were confined to lower weight gains and food conversion efficiency in males and females ingesting 6000 or 12,000 ppm."( Carcinogenicity and chronic toxicity of di-2-ethylhexyl terephthalate (DEHT) following a 2-year dietary exposure in Fischer 344 rats.
Deyo, JA, 2008)		0.35
"DEHT administered via intravenous infusion was tolerated systemically and locally without adverse effects up to and including 381."( Systemic toxicity of di-2-ethylhexyl terephthalate (DEHT) in rodents following four weeks of intravenous exposure.
Katerkamp, A; Rickenbacher, U; Schachtrupp, A; Wirnitzer, U, 2011)		0.37
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (5)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
GLI family zinc finger 3Homo sapiens (human)Potency0.53870.000714.592883.7951AID1259369
AR proteinHomo sapiens (human)Potency45.97380.000221.22318,912.5098AID588515; AID743042
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency0.01580.000214.376460.0339AID588532
estrogen nuclear receptor alphaHomo sapiens (human)Potency24.54120.000229.305416,493.5996AID743075
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency30.29550.000323.4451159.6830AID743065
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (23)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (4.35)18.7374
1990's3 (13.04)18.2507
2000's5 (21.74)29.6817
2010's11 (47.83)24.3611
2020's3 (13.04)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 35.00

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index35.00 (24.57)
Research Supply Index3.18 (2.92)
Research Growth Index5.13 (4.65)
Search Engine Demand Index42.88 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (35.00)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (4.35%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other22 (95.65%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
phthalic acid
phthalic acid: RN given refers to parent cpd; structure in Merck Index, 9th ed, #7178. phthalic acid : A benzenedicarboxylic acid cosisting of two carboxy groups at ortho positions.		2.0810benzenedicarboxylic acidhuman xenobiotic metabolite
dibutyl phthalate
Dibutyl Phthalate: A plasticizer used in most plastics and found in water, air, soil, plants and animals. It may have some adverse effects with long-term exposure.. dibutyl phthalate : A phthalate ester that is the diester obtained by the formal condensation of the carboxy groups of phthalic acid with two molecules of butan-1-ol. Although used extensively as a plasticiser, it is a ubiquitous environmental contaminant that poses a risk to humans.		2.0810diester;
phthalate ester		EC 3.2.1.20 (alpha-glucosidase) inhibitor;
environmental contaminant;
metabolite;
plasticiser;
teratogenic agent
androstenedione
Androstenedione: A delta-4 C19 steroid that is produced not only in the TESTIS, but also in the OVARY and the ADRENAL CORTEX. Depending on the tissue type, androstenedione can serve as a precursor to TESTOSTERONE as well as ESTRONE and ESTRADIOL.. androst-4-ene-3,17-dione : A 3-oxo Delta(4)-steroid that is androst-4-ene substituted by oxo groups at positions 3 and 17. It is a steroid hormone synthesized in the adrenal glands and gonads.		2.011017-oxo steroid;
3-oxo-Delta(4) steroid;
androstanoid		androgen;
Daphnia magna metabolite;
human metabolite;
mouse metabolite
phencyclidine
Phencyclidine: A hallucinogen formerly used as a veterinary anesthetic, and briefly as a general anesthetic for humans. Phencyclidine is similar to KETAMINE in structure and in many of its effects. Like ketamine, it can produce a dissociative state. It exerts its pharmacological action through inhibition of NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE). As a drug of abuse, it is known as PCP and Angel Dust.. phencyclidine : A member of the class of piperidines that is piperidine in which the nitrogen is substituted with a 1-phenylcyclohexyl group. Formerly used as an anaesthetic agent, it exhibits both hallucinogenic and neurotoxic effects.		2.0610benzenes;
piperidines		anaesthetic;
neurotoxin;
NMDA receptor antagonist;
psychotropic drug
terephthalic acid
terephthalic acid: RN given refers to 1,4-benzenedicarboxylic acid. terephthalic acid : A benzenedicarboxylic acid carrying carboxy groups at positions 1 and 4. One of three possible isomers of benzenedicarboxylic acid, the others being phthalic and isophthalic acids.		2.4520benzenedicarboxylic acid
2-ethylhexanol
[no description available]		1.9810primary alcoholplant metabolite;
volatile oil component
1-hexanol
1-hexanol: RN given refers to parent cpd. hexanol : A fatty alcohol consisting of a hydroxy function at any position of an unbranched saturated chain of six carbon atoms.. hexan-1-ol : A primary alcohol that is hexane substituted by a hydroxy group at position 1.		1.9810hexanol;
primary alcohol		alarm pheromone;
antibacterial agent;
fragrance;
plant metabolite
diethylhexyl phthalate
Diethylhexyl Phthalate: An ester of phthalic acid. It appears as a light-colored, odorless liquid and is used as a plasticizer for many resins and elastomers.. bis(2-ethylhexyl) phthalate : A phthalate ester that is the bis(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.		3.4270diester;
phthalate ester		androstane receptor agonist;
apoptosis inhibitor;
plasticiser
tri-(2-ethylhexyl)trimellitate
tri-(2-ethylhexyl)trimellitate: authors commonly refer to it as trioctyl trimellitate		2.1310benzoate ester
dioctyl adipate
[no description available]		2.0410carboxylic ester
2-methyl-5,6-cyclopentapyrimidine
2-methyl-5,6-cyclopentapyrimidine: structure given in first source; RN given is CAS no. reported in first source		2.2110
mono(2-ethyl-5-hydroxyhexyl) phthalate
mono(2-ethyl-5-hydroxyhexyl) phthalate: a metabolite of bis(2-ethylhexyl) phthalate. mono(2-ethyl-5-hydroxyhexyl) phthalate : A phthalic acid monoester obtained by formal condensation of one of the carboxy groups of phthalic acid with the primary hydroxy group of 2-ethylhexane-1,5-diol		2.2110phthalic acid monoesterhuman urinary metabolite;
human xenobiotic metabolite
diisononyl phthalate
diisononyl phthalate: dielectric (electric insulating) fluid. diisononyl phthalate : The diisononyl ester of benzene-1,2-dicarboxylic acid.		2.1310diester;
phthalate ester		plasticiser
palmitoyl coenzyme a
Palmitoyl Coenzyme A: A fatty acid coenzyme derivative which plays a key role in fatty acid oxidation and biosynthesis.. palmitoyl-CoA : A long-chain fatty acyl-CoA resulting from the formal condensation of the carboxy group of hexadecanoic acid with the thiol group of coenzyme A.		1.971011,12-saturated fatty acyl-CoA;
3-substituted propionyl-CoA;
long-chain fatty acyl-CoA;
palmitoyl bioconjugate		Escherichia coli metabolite;
mouse metabolite
ConditionIndicatedRelationship StrengthStudiesTrials
Extravascular Hemolysis
[description not available]		02.3110
Hemolysis
The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.		02.3110
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		02.1310
Anxiety
Feelings or emotions of dread, apprehension, and impending disaster but not disabling as with ANXIETY DISORDERS.		02.0810
Pregnancy
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.		02.0810
Experimental Neoplasms
[description not available]		02.0410
Body Weight
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.		02.3820
Abnormalities, Autosome
[description not available]		01.9810