Compounds > flocoumafen
Page last updated: 2024-11-13

flocoumafen

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID54698175
CHEBI ID81894
SCHEMBL ID53493
SCHEMBL ID53492
MeSH IDM0138518

Synonyms (32)

Synonym
2h-1-benzopyran-2-one, 4-hydroxy-3-(1,2,3,4-tetrahydro-3-(4-((4-(trifluoromethyl)phenyl)methoxy)phenyl)-1-naphthalenyl)-
wl 108366
4-hydroxy-3-(1,2,3,4-tetrahydro-3-(4-(4-trifluoromethylbenzyloxy)phenyl)-1-naphthyl)coumarin
storm
flocoumafen [bsi:iso]
flocoumafene [iso-french]
flocoumafene
hsdb 6643
stratgem
flocoumafen
D07134
flocoumafen (jan)
90035-08-8
C18696
unii-2z80062xq4
2z80062xq4 ,
ec 421-960-0
SCHEMBL53493
SCHEMBL53492
CHEBI:81894
2h-1-benzopyran-2-one, 4-hydroxy-3-[1,2,3,4-tetrahydro-3-[4-[[4-(trifluoromethyl)phenyl]methoxy]phenyl]-1-naphthalenyl]-
DTXSID1058212
1-(4-hydroxycoumarin-3-yl)-3-[4-(4-trifluoromethylbenzyloxy)phenyl]-1,2,3,4-tetrahydronaphthalene
flocoumafen, pestanal(r), analytical standard
flocoumafen 10 microg/ml in acetonitrile
4-hydroxy-3-(3-(4-(4-(trifluoromethyl)benzyloxy)phenyl)-1,2,3,4-tetrahydronaphthalen-1-yl)-2h-chromen-2-one
Q408221
F17478
CS-0034563
4-hydroxy-3-[3-[4-[[4-(trifluoromethyl)phenyl]methoxy]phenyl]-1,2,3,4-tetrahydronaphthalen-1-yl]chromen-2-one
HY-111186
owuzcvprfksbrg-uhfffaoysa-n

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
"The differences in chemical structure between DFM on the one hand and BFM, FLO and DFTL on the other could explain the differences in bioavailability between these two groups of molecules."( Mass spectrometry characterization of anticoagulant rodenticides and hydroxyl metabolites.
Benoit, E; Berlioz-Barbier, A; Fourel, I, 2020)		0.56

Dosage Studied

ExcerptRelevanceReference
" At 7 days after dosing 12% of the administered radioactivity remained at the site of application, while 25% was located in the liver as unchanged flocoumafen."( The percutaneous fate of the rodenticide flocoumafen in the rat: role of non-biliary intestinal excretion.
Huckle, KR; Morrison, BJ; Warburton, PA, 1989)		0.74
" Amounts of the polar products increased with cumulative dosage received."( Elimination and accumulation of the rodenticide flocoumafen in rats following repeated oral administration.
Huckle, KR; Hutson, DH; Warburton, PA, 1988)		0.53
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (3)

ClassDescription
ring assemblyTwo or more cyclic systems (single rings or fused systems) which are directly joined to each other by double or single bonds are named ring assemblies when the number of such direct ring junctions is one less than the number of cyclic systems involved.
naphthalenesAny benzenoid aromatic compound having a skeleton composed of two ortho-fused benzene rings.
benzenesAny benzenoid aromatic compound consisting of the benzene skeleton and its substituted derivatives.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (23)

TimeframeStudies, This Drug (%)All Drugs %
pre-19906 (26.09)18.7374
1990's1 (4.35)18.2507
2000's3 (13.04)29.6817
2010's9 (39.13)24.3611
2020's4 (17.39)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 31.39

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index31.39 (24.57)
Research Supply Index3.22 (2.92)
Research Growth Index5.20 (4.65)
Search Engine Demand Index72.88 (26.88)
Search Engine Supply Index4.00 (0.95)

This Compound (31.39)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies2 (8.33%)4.05%
Observational0 (0.00%)0.25%
Other22 (91.67%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
chlorophacinone
chlorophacinone: structure		2.0610beta-triketone;
diarylmethane
4-anisaldehyde
4-anisaldehyde: RN given refers to cpd with specified locants for methoxy moieties; structure in Merck, 9th ed, #696. p-methoxybenzaldehyde : A member of the class of benzaldehydes consisting of benzaldehyde itself carrying a methoxy substituent at position 4.		2.0710benzaldehydesbacterial metabolite;
human urinary metabolite;
insect repellent;
plant metabolite
difethialone
[no description available]		7.9330
vitamin k semiquinone radical
vitamin K semiquinone radical: found in active preparations of vitamin K-dependent carboxylase. vitamin K : Any member of a group of fat-soluble 2-methyl-1,4-napthoquinones that exhibit biological activity against vitamin K deficiency. Vitamin K is required for the synthesis of prothrombin and certain other blood coagulation factors.		2.4120
difenacoum
diphenacoum: structure in first source		3.3960benzenes;
naphthalenes;
ring assembly
warfarin
Warfarin: An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.. warfarin : A racemate comprising equal amounts of (R)- and (S)-warfarin. Extensively used as both an anticoagulant drug and as a pesticide against rats and mice.. 4-hydroxy-3-(3-oxo-1-phenylbutyl)-1-benzopyran-2-one : A member of the class of coumarins that is 4-hydroxycoumarin which is substituted at position 3 by a 1-phenyl-3-oxo-1-butyl group.		3.1350benzenes;
hydroxycoumarin;
methyl ketone
coumatetralyl
coumatetralyl: structure		2.7730hydroxycoumarin
ferulenol
ferulenol: intoxicating component of powdered Ferula communis variety brevifolia; RN given for (E,E)-isomer		2.1310
bromadiolone
[no description available]		8.4770diarylheptanoid
bromfenacoum
[no description available]		3.79100benzenes;
naphthalenes;
ring assembly
coumachlor
coumachlor: C19-H15-Cl-O4		2.1310hydroxycoumarin
4-hydroxycoumarin
2-hydroxychromone: structure		2.0710hydroxycoumarin
ConditionIndicatedRelationship StrengthStudiesTrials
Poisoning
Used with drugs, chemicals, and industrial materials for human or animal poisoning, acute or chronic, whether the poisoning is accidental, occupational, suicidal, by medication error, or by environmental exposure.		02.2510
Coagulation, Disseminated Intravascular
[description not available]		02.0610
Disseminated Intravascular Coagulation
A disorder characterized by procoagulant substances entering the general circulation causing a systemic thrombotic process. The activation of the clotting mechanism may arise from any of a number of disorders. A majority of the patients manifest skin lesions, sometimes leading to PURPURA FULMINANS.		02.0610
Body Weight
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.		01.9710