clathrodin and hymenidin

clathrodin has been researched along with hymenidin* in 2 studies

Other Studies

2 other study(ies) available for clathrodin and hymenidin

ArticleYear
Clathrodin, hymenidin and oroidin, and their synthetic analogues as inhibitors of the voltage-gated potassium channels.
    European journal of medicinal chemistry, 2017, Oct-20, Volume: 139

    We have prepared three alkaloids from the Agelas sponges, clathrodin, hymenidin and oroidin, and a series of their synthetic analogues, and evaluated their inhibitory effect against six isoforms of the K

    Topics: Dose-Response Relationship, Drug; Humans; Molecular Structure; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Pyrroles; Structure-Activity Relationship

2017
Total syntheses of oroidin, hymenidin and clathrodin.
    Organic & biomolecular chemistry, 2013, Jul-07, Volume: 11, Issue:25

    The total syntheses of oroidin, hymenidin and clathrodin are reported via the intermediacy of an imidazo[1,2-a]pyrimidine derivative. The chemistry described herein obviates the need for expensive guanidine reagents, multiply protected prefunctionalized 2-aminoimidazole synthons, or the need for laborious olefinations thereby achieving synthetic efficiency amenable to scale-up. The approach outlined in this manuscript provides an opportunity for further functionalizations through the imidazo[1,2-a]pyrimidine core and through functional groups placed strategically on the side chain.

    Topics: Models, Molecular; Pyrimidines; Pyrroles

2013