clathrodin has been researched along with hymenidin* in 2 studies
2 other study(ies) available for clathrodin and hymenidin
Article | Year |
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Clathrodin, hymenidin and oroidin, and their synthetic analogues as inhibitors of the voltage-gated potassium channels.
We have prepared three alkaloids from the Agelas sponges, clathrodin, hymenidin and oroidin, and a series of their synthetic analogues, and evaluated their inhibitory effect against six isoforms of the K Topics: Dose-Response Relationship, Drug; Humans; Molecular Structure; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Pyrroles; Structure-Activity Relationship | 2017 |
Total syntheses of oroidin, hymenidin and clathrodin.
The total syntheses of oroidin, hymenidin and clathrodin are reported via the intermediacy of an imidazo[1,2-a]pyrimidine derivative. The chemistry described herein obviates the need for expensive guanidine reagents, multiply protected prefunctionalized 2-aminoimidazole synthons, or the need for laborious olefinations thereby achieving synthetic efficiency amenable to scale-up. The approach outlined in this manuscript provides an opportunity for further functionalizations through the imidazo[1,2-a]pyrimidine core and through functional groups placed strategically on the side chain. Topics: Models, Molecular; Pyrimidines; Pyrroles | 2013 |