Page last updated: 2024-12-07
cerebronic acid
Description
Cerebronic acid, also known as 2-hydroxytetracosanoic acid, is a long-chain fatty acid found in the brain and other tissues. It is a component of sphingolipids, which are important for cell signaling and membrane structure. Cerebronic acid is synthesized from palmitic acid and stearic acid through a series of enzymatic reactions. Its biosynthesis involves the elongation of palmitate to form the 24-carbon chain. It has been studied for its potential role in various neurological disorders, including Alzheimer's disease and multiple sclerosis. The accumulation of cerebronic acid in the brain has been linked to the formation of plaques, which are characteristic of Alzheimer's disease. Its role in multiple sclerosis is related to its presence in myelin, the protective sheath around nerve fibers. Studies on cerebronic acid aim to understand its role in brain function and its potential as a therapeutic target in neurological disorders.'
cerebronic acid : A very long-chain hydroxy fatty acid composed of lignoceric acid having a 2-hydroxy substituent. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
Cross-References
| ID Source | ID |
|---|
| PubMed CID | 102430 |
| CHEBI ID | 61302 |
| SCHEMBL ID | 338278 |
| MeSH ID | M0045224 |
Synonyms (29)
| Synonym |
|---|
| 544-57-0 |
| dl-cerebronic acid |
| phrenosinic acid |
| 2-hydroxy-tetracosanoic acid |
| LMFA01050080 |
| phrenosic acid |
| 2-hydroxytetracosanoic acid |
| cerebronic acid |
| CHEBI:61302 |
| 2-hydroxytetraicosanoic acid |
| 2-hydroxytetraeicosanoic acid |
| cerebronsaeure |
| 2-hydroxylignoceric acid |
| acide cerebronique |
| 2-hydroxy-tetracosansaeure |
| C17873 |
| unii-66qn3b074e |
| 66qn3b074e , |
| FT-0632358 |
| SCHEMBL338278 |
| .alpha.-hydroxytetracosanoic acid |
| tetracosanoic acid, 2-hydroxy- |
| .alpha.-hydroxylignoceric acid |
| AKOS027379899 |
| 2-hydroxy lignoceric acid |
| a-hydroxylignoceric acid |
| Q11751627 |
| DTXSID40969526 |
| PD060508 |
Drug Classes (3)
| Class | Description |
|---|
| straight-chain fatty acid | Any fatty acid whose skeletal carbon atoms form an unbranched open chain. |
| 2-hydroxy fatty acid | Any fatty acid with a hydroxy functional group in the alpha- or 2-position. |
| very long-chain fatty acid | A fatty acid which has a chain length greater than C22. Very long-chain fatty acids which have a chain length greater than C27 are also known as ultra-long-chain fatty acids. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] |
Research
Studies (5)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|
| pre-1990 | 3 (60.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 50.97
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.
| Metric | This Compound (vs All) |
|---|
| Research Demand Index | 50.97 (24.57) | | Research Supply Index | 1.79 (2.92) | | Research Growth Index | 4.21 (4.65) | | Search Engine Demand Index | 73.70 (26.88) | | Search Engine Supply Index | 2.00 (0.95) |
| |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |