Compounds > calcifediol lactone
Page last updated: 2024-12-11

calcifediol lactone

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Description

calcifediol lactone: vitamin D3 metabolite; competes actively for vitamin D binding protein in ligand assay for 25-hydroxyvitamin D3; RN given refers to (3beta,5Z,7E)-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID6438386
MeSH IDM0086722

Synonyms (8)

Synonym
calcifediol lactone
5-[(2r)-2-[(1r,3as,4e,7ar)-4-[(2z)-2-[(5s)-5-hydroxy-2-methylidenecyclohexylidene]ethylidene]-7a-methyl-2,3,3a,5,6,7-hexahydro-1h-inden-1-yl]propyl]-3-hydroxy-3-methyloxolan-2-one
25-hydroxycholecalciferol-26,23-lactone
9,10-secocholesta-5,7,10(19)-trien-26-oic acid, 3,23,25-trihydroxy-, gamma-lactone, (3beta,5z,7e)-
25-ohd(3)-26,23-lactone
25-hydroxy vitamin d3-26,23-lactone
25-hydroxyvitamin d(3) 26,23-lactone
71302-34-6
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (26)

TimeframeStudies, This Drug (%)All Drugs %
pre-199023 (88.46)18.7374
1990's1 (3.85)18.2507
2000's0 (0.00)29.6817
2010's2 (7.69)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 10.81

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index10.81 (24.57)
Research Supply Index3.30 (2.92)
Research Growth Index4.11 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (10.81)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (3.85%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other25 (96.15%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
hydroxyproline
Hydroxyproline: A hydroxylated form of the imino acid proline. A deficiency in ASCORBIC ACID can result in impaired hydroxyproline formation.. hydroxyproline : A proline derivative that is proline substituted by at least one hydroxy group.		1.96104-hydroxyproline;
L-alpha-amino acid zwitterion		human metabolite;
mouse metabolite;
plant metabolite
7-dehydrocholesterol
[no description available]		3.06103beta-hydroxy-Delta(5)-steroid;
3beta-sterol;
cholestanoid;
Delta(5),Delta(7)-sterol		human metabolite;
mouse metabolite
calcitriol
dihydroxy-vitamin D3: as a major in vitro metabolite of 1alpha,25-dihydroxyvitamin D3, produced in primary cultures of neonatal human keratinocytes		3.84120D3 vitamins;
hydroxycalciol;
triol		antineoplastic agent;
antipsoriatic;
bone density conservation agent;
calcium channel agonist;
calcium channel modulator;
hormone;
human metabolite;
immunomodulator;
metabolite;
mouse metabolite;
nutraceutical
vitamin d 2
Ergocalciferols: Derivatives of ERGOSTEROL formed by ULTRAVIOLET RAYS breaking of the C9-C10 bond. They differ from CHOLECALCIFEROL in having a double bond between C22 and C23 and a methyl group at C24.. vitamin D2 : A vitamin D supplement and has been isolated from alfalfa.		2.6530hydroxy seco-steroid;
seco-ergostane;
vitamin D		bone density conservation agent;
nutraceutical;
plant metabolite;
rodenticide
cholecalciferol
Cholecalciferol: Derivative of 7-dehydroxycholesterol formed by ULTRAVIOLET RAYS breaking of the C9-C10 bond. It differs from ERGOCALCIFEROL in having a single bond between C22 and C23 and lacking a methyl group at C24.. calciol : A hydroxy seco-steroid that is (5Z,7E)-9,10-secocholesta-5,7,10(19)-triene in which the pro-S hydrogen at position 3 has been replaced by a hydroxy group. It is the inactive form of vitamin D3, being hydroxylated in the liver to calcidiol (25-hydroxyvitamin D3), which is then further hydroxylated in the kidney to give calcitriol (1,25-dihydroxyvitamin D3), the active hormone.		4.6790D3 vitamins;
hydroxy seco-steroid;
seco-cholestane;
secondary alcohol;
steroid hormone		geroprotector;
human metabolite
25-hydroxy-24-oxocholecalciferol
25-hydroxy-24-oxocholecalciferol: metabolite of 25-hydroxycholecalciferol		3.0610hydroxycalciol;
oxocalciol;
tertiary alpha-hydroxy ketone
phosphorus
Phosphorus: A non-metal element that has the atomic symbol P, atomic number 15, and atomic weight 31. It is an essential element that takes part in a broad variety of biochemical reactions.		1.9610monoatomic phosphorus;
nonmetal atom;
pnictogen		macronutrient
25-hydroxyvitamin d 2
25-Hydroxyvitamin D 2: 9,10-Secoergosta-5,7,10(19),22-tetraene-3,25-diol. Biologically active metabolite of vitamin D2 which is more active in curing rickets than its parent. The compound is believed to attach to the same receptor as vitamin D2 and 25-hydroxyvitamin D3.		1.9610hydroxycalciol;
seco-ergostane;
vitamin D		bone density conservation agent;
human xenobiotic metabolite;
nutraceutical
24,25-dihydroxyvitamin d 3
24,25-Dihydroxyvitamin D 3: A physiologically active metabolite of VITAMIN D. The compound is involved in the regulation of calcium metabolism, alkaline phosphatase activity, and enhancing the calcemic effect of CALCITRIOL.		4.5680
1,25-dihydroxyvitamin d3-26,23-lactone
[no description available]		2.6530vitamin D
26-hydroxycholecalciferol
26-hydroxycholecalciferol: RN given refers to (25R)-isomer; RN for cpd without isomeric designation not in Cheline 8/9/83		1.9610
calcitroic acid
calcitroic acid: structure. calcitroic acid : A hydroxycalciol that is calcidiol in which the pro-S hydrogen of calcidiol is replaced by a hydroxy group and the C-23/C-27 unit is replaced by a carboxy group.		1.9510hydroxycalciol
23,25-dihydroxyvitamin d3
23,25-dihydroxyvitamin D3: metabolite of vitamin D3 in chickens & rats; RN given refers to (3beta,5Z,7E)-isomer		2.8740
25,26-dihydroxycholecalciferol
25,26-dihydroxycholecalciferol: RN given refers to (3beta,5A,7E)-isomer		3.0650
ConditionIndicatedRelationship StrengthStudiesTrials
Milk-Alkali Syndrome
[description not available]		02.3920
Hypercalcemia
Abnormally high level of calcium in the blood.		02.3920
Chronic Kidney Failure
[description not available]		02.3720
Kidney Failure, Chronic
The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.		02.3720
Bovine Diseases
[description not available]		01.9610
Pregnancy
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.		01.9610
Deficiency, Vitamin D
[description not available]		02.3620
Vitamin D Deficiency
A nutritional condition produced by a deficiency of VITAMIN D in the diet, insufficient production of vitamin D in the skin, inadequate absorption of vitamin D from the diet, or abnormal conversion of vitamin D to its bioactive metabolites. It is manifested clinically as RICKETS in children and OSTEOMALACIA in adults. (From Cecil Textbook of Medicine, 19th ed, p1406)		02.3620
Aging
The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.		01.9610
Rachitis
[description not available]		01.9510