Compounds > vibrioferrin
Page last updated: 2024-11-08

vibrioferrin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

vibrioferrin: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

vibrioferrin : A tricarboxylic acid that is citric acid in which the pro-R carboxy group has been esterified with the primary hydroxy group of 2-hydroxy-1-{(2S)-1-[(2-hydroxyethyl)amino]-1-oxopropan-2-yl}-5-oxoproline. It is a siderophore isolated from bacteria closely associated or symbiotic with toxic, bloom-forming dinoflagellates. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID11102119
CHEBI ID84585
MeSH IDM0238186

Synonyms (6)

Synonym
vibrioferrin
CHEBI:84585
(2r)-2-[2-(2-{[(2s)-2-(2-carboxy-2-hydroxy-5-oxopyrrolidin-1-yl)propanoyl]amino}ethoxy)-2-oxoethyl]-2-hydroxysuccinic acid
Q27157888
DTXSID601103910
1-[2-[[(2s)-2-(2-carboxy-2-hydroxy-5-oxo-1-pyrrolidinyl)-1-oxopropyl]amino]ethyl] (2r)-2-hydroxy-1,2,3-propanetricarboxylate

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
"Iron is an essential element for oceanic microbial life but its low bioavailability limits microorganisms in large areas of the oceans."( Siderophore-mediated iron uptake in two clades of Marinobacter spp. associated with phytoplankton: the role of light.
Amin, SA; Carrano, CJ; Gärdes, A; Green, DH; Romano, A; Trimble, L, 2012)		0.38
"Iron is an essential element for oceanic microbial life but its low bioavailability limits microorganisms in large areas of the oceans."( Detection of photoactive siderophore biosynthetic genes in the marine environment.
Amin, SA; Carrano, CJ; Gärdes, A; Green, DH; Romano, A; Triana, C; Trimble, L, 2013)		0.39
" However, the bioavailability of iron is extremely low because it is usually present as an insoluble ferric complex in an aerobic environment or is bound to iron-binding proteins in mammalian hosts."( Regulation of the Expression of Iron-acquisition System Genes in Pathogenic Vibrio Species.
Tanabe, T, 2016)		0.43
" Vibroferrin's unique properties and the widespread prevalence of its bacterial producers suggest that it may contribute significantly to generating bioavailability of iron via photoredox reactions."( Distribution of dissolved iron and bacteria producing the photoactive siderophore, vibrioferrin, in waters off Southern California and Northern Baja.
Carrano, CJ; Carter, ML; Cruz-López, R; Edwards, M; García-Mendoza, E; Yarimizu, K, 2019)		0.51
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (2)

RoleDescription
siderophoreAny of low-molecular-mass iron(III)-chelating compounds produced by microorganisms for the purpose of the transport and sequestration of iron.
marine metaboliteAny metabolite produced during a metabolic reaction in marine macro- and microorganisms.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (5)

ClassDescription
tertiary alcoholA tertiary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has three other carbon atoms attached to it.
pyrrolidin-2-onesA pyrrolidinone in which the oxo group is at position 2 of the pyrrolidine ring.
tricarboxylic acidAn oxoacid containing three carboxy groups.
carboxylic esterAn ester of a carboxylic acid, R(1)C(=O)OR(2), where R(1) = H or organyl and R(2) = organyl.
N-acyl hemiaminalAn organic hydroxy compound resulting from the formal addition of the amino group of a carboxamide to the carbonyl group of an aldehyde or ketone.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (26)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's4 (15.38)18.2507
2000's8 (30.77)29.6817
2010's14 (53.85)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (7.69%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other24 (92.31%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
catechol
[no description available]		2.1510catecholsallelochemical;
genotoxin;
plant metabolite
citric acid, anhydrous
Citric Acid: A key intermediate in metabolism. It is an acid compound found in citrus fruits. The salts of citric acid (citrates) can be used as anticoagulants due to their calcium chelating ability.. citric acid : A tricarboxylic acid that is propane-1,2,3-tricarboxylic acid bearing a hydroxy substituent at position 2. It is an important metabolite in the pathway of all aerobic organisms.		2.1510tricarboxylic acidantimicrobial agent;
chelator;
food acidity regulator;
fundamental metabolite
deferoxamine
Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.. desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.		3.1210acyclic desferrioxaminebacterial metabolite;
ferroptosis inhibitor;
iron chelator;
siderophore
molybdenum
Molybdenum: A metallic element with the atomic symbol Mo, atomic number 42, and atomic weight 95.95. It is an essential trace element, being a component of the enzymes xanthine oxidase, aldehyde oxidase, and nitrate reductase.		2.1510chromium group element atommicronutrient
vanadium
Vanadium: A metallic element with the atomic symbol V, atomic number 23, and atomic weight 50.94. It is used in the manufacture of vanadium steel. Prolonged exposure can lead to chronic intoxication caused by absorption usually via the lungs.		2.1510elemental vanadium;
vanadium group element atom		micronutrient
transferrin
Transferrin: An iron-binding beta1-globulin that is synthesized in the LIVER and secreted into the blood. It plays a central role in the transport of IRON throughout the circulation. A variety of transferrin isoforms exist in humans, including some that are considered markers for specific disease states.		1.9810
aerobactin
[no description available]		3.8330L-lysine derivativeEscherichia coli metabolite;
siderophore;
virulence factor
rhizoferrin
rhizoferrin: a ferric polycarboxylate; a complexone-type siderophore; synthesized and secreted by Rhizopus microsporus		2.0310
boron
Boron: A trace element with the atomic symbol B, atomic number 5, and atomic weight [10.806; 10.821]. Boron-10, an isotope of boron, is used as a neutron absorber in BORON NEUTRON CAPTURE THERAPY.		2.4420boron group element atom;
metalloid atom;
nonmetal atom		micronutrient
petrobactin
petrobactin: a photoreactive siderophore produced by the oil-degrading marine bacterium; structure in first source		2.4620
alcaligin
alcaligin: a siderophore produced by Bordetella & Alcaligenes sp.; structure given in first source		3.1210cyclic hydroxamic acid
nitrogenase
Nitrogenase: An enzyme system that catalyzes the fixing of nitrogen in soil bacteria and blue-green algae (CYANOBACTERIA). EC 1.18.6.1.		2.1510
achromobactin
achromobactin: isolated from Erwinia chrysanthemi; structure in first source. achromobactin : A citrate siderophore possessing four carboxylate groups suitable for iron coordination.		3.1210tetracarboxylic acid anionsiderophore
ConditionIndicatedRelationship StrengthStudiesTrials
Fish Diseases
Diseases of freshwater, marine, hatchery or aquarium fish. This term includes diseases of both teleosts (true fish) and elasmobranchs (sharks, rays and skates).		02.7830
Infections, Vibrio
[description not available]		02.7330
Cronobacter Infections
[description not available]		02.1310
Enterobacteriaceae Infections
Infections with bacteria of the family ENTEROBACTERIACEAE.		02.1310