Target type: biologicalprocess
The chemical reactions and pathways resulting in the breakdown of putrescine, 1,4-diaminobutane; putrescine is the metabolic precursor of spermidine and spermine. [GOC:ai]
Putrescine catabolic process is the metabolic breakdown of putrescine, a polyamine that plays a significant role in various cellular processes, including cell growth, differentiation, and proliferation. The process begins with the oxidation of putrescine by the enzyme diamine oxidase (DAO), which converts it to 4-aminobutylaldehyde. This aldehyde is then further oxidized by the enzyme aldehyde dehydrogenase to γ-aminobutyric acid (GABA), a neurotransmitter. The breakdown of putrescine can occur in various cellular compartments, including the cytoplasm, mitochondria, and peroxisomes. The catabolism of putrescine is tightly regulated and is influenced by factors such as dietary intake, hormonal levels, and cellular stress. Disruptions in putrescine catabolism can contribute to various pathological conditions, including cancer, neurodegenerative diseases, and inflammatory disorders.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Peroxisomal N(1)-acetyl-spermine/spermidine oxidase | A peroxisomal N(1)-acetyl-spermine/spermidine oxidase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6QHF9] | Homo sapiens (human) |
| Diamine acetyltransferase 1 | A diamine acetyltransferase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P21673] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| n(1)-acetylspermidine | N(1)-acetylspermidine : An acetylspermidine having the acetyl group at the N1-position. | acetylspermidine | Escherichia coli metabolite; metabolite |
| diminazene | diminazene : A triazene derivative that is triazene in which each of the terminal nitrogens is substituted by a 4-carbamimidoylphenyl group. Diminazene: An effective trypanocidal agent. | carboxamidine; triazene derivative | antiparasitic agent; trypanocidal drug |
| pentamidine | pentamidine : A diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease. Pentamidine: Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. | aromatic ether; carboxamidine; diether | anti-inflammatory agent; antifungal agent; calmodulin antagonist; chemokine receptor 5 antagonist; EC 2.3.1.48 (histone acetyltransferase) inhibitor; NMDA receptor antagonist; S100 calcium-binding protein B inhibitor; trypanocidal drug; xenobiotic |
| trientine | 2,2,2-tetramine : A polyazaalkane that is decane in which the carbon atoms at positions 1, 4, 7 and 10 are replaced by nitrogens. TETA : An azamacrocyle in which four nitrogen atoms at positions 1, 4, 8 and 11 of a fouteen-membered ring are each substituted with a carboxymethyl group. Trientine: An ethylenediamine derivative used as stabilizer for EPOXY RESINS, as ampholyte for ISOELECTRIC FOCUSING and as chelating agent for copper in HEPATOLENTICULAR DEGENERATION. | polyazaalkane; tetramine | copper chelator |
| n-acetylputrescine | N-acetylputrescine : An N-monoacetylalkane-alpha,omega-diamine that is the N-monoacetyl derivative of putrescine. | N-monoacetylalkane-alpha,omega-diamine; N-substituted putrescine | metabolite; mouse metabolite |
| n(8)-acetylspermidine | N(8)-acetylspermidine : An acetylspermidine that is 1,8-diamino-4-azaoctane in which one of the hydrogens of the amino group attached to C-8 is replaced by an acetyl group. | acetylspermidine | Escherichia coli metabolite; human metabolite |
| 7-(n-(3-aminopropyl)amino)heptan-2-one | 7-(N-(3-aminopropyl)amino)heptan-2-one: inhibits N(8)-acetylspermidine deacetylation in mice | ||
| n-acetyl-1,6-diaminohexane | |||
| chlorhexidine | chlorhexidine : A bisbiguanide compound with a structure consisting of two (p-chlorophenyl)guanide units linked by a hexamethylene bridge. Chlorhexidine: A disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque. | biguanides; monochlorobenzenes | antibacterial agent; antiinfective agent |