Target type: molecularfunction
Catalysis of the reaction: H2O + N(1)-acetylspermine + O2 = 3-acetamidopropanal + H2O2 + spermidine. [RHEA:25800]
N1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity catalyzes the oxidation of N1-acetylspermine, a polyamine derivative, to 3-acetamidopropanal. This reaction involves the transfer of two electrons from N1-acetylspermine to molecular oxygen, resulting in the formation of hydrogen peroxide and the cleavage of the C-N bond between the N1-acetylated spermine and the adjacent carbon atom. The enzyme specifically recognizes and binds to N1-acetylspermine as a substrate. The reaction mechanism involves the initial formation of a reactive oxygen species, such as a superoxide radical, which then reacts with N1-acetylspermine to initiate the oxidation process. This enzyme activity is crucial for the regulation of polyamine metabolism, which plays a role in various cellular processes such as cell growth, proliferation, and differentiation.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Peroxisomal N(1)-acetyl-spermine/spermidine oxidase | A peroxisomal N(1)-acetyl-spermine/spermidine oxidase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6QHF9] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| n(1)-acetylspermidine | N(1)-acetylspermidine : An acetylspermidine having the acetyl group at the N1-position. | acetylspermidine | Escherichia coli metabolite; metabolite |
| n-acetylputrescine | N-acetylputrescine : An N-monoacetylalkane-alpha,omega-diamine that is the N-monoacetyl derivative of putrescine. | N-monoacetylalkane-alpha,omega-diamine; N-substituted putrescine | metabolite; mouse metabolite |
| n(8)-acetylspermidine | N(8)-acetylspermidine : An acetylspermidine that is 1,8-diamino-4-azaoctane in which one of the hydrogens of the amino group attached to C-8 is replaced by an acetyl group. | acetylspermidine | Escherichia coli metabolite; human metabolite |
| 7-(n-(3-aminopropyl)amino)heptan-2-one | 7-(N-(3-aminopropyl)amino)heptan-2-one: inhibits N(8)-acetylspermidine deacetylation in mice | ||
| n-acetyl-1,6-diaminohexane | |||
| chlorhexidine | chlorhexidine : A bisbiguanide compound with a structure consisting of two (p-chlorophenyl)guanide units linked by a hexamethylene bridge. Chlorhexidine: A disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque. | biguanides; monochlorobenzenes | antibacterial agent; antiinfective agent |