Target type: molecularfunction
Catalysis of the reaction: H2O + N(1)-acetylspermidine + O2 = 3-acetamidopropanal + H2O2 + putrescine. [RHEA:25812]
N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity catalyzes the oxidation of N1-acetylspermidine to 3-acetamidopropanal and 1,3-diaminopropane. This enzyme is a member of the amine oxidase family and uses molecular oxygen as an electron acceptor. The reaction proceeds through a two-step mechanism. In the first step, the enzyme oxidizes N1-acetylspermidine to an imine intermediate. In the second step, the imine intermediate is hydrolyzed to 3-acetamidopropanal and 1,3-diaminopropane. The enzyme is specific for N1-acetylspermidine and does not oxidize other polyamines such as spermidine or spermine. This enzyme is important for the degradation of N1-acetylspermidine, a polyamine that is found in various tissues. The enzyme activity is regulated by the concentration of N1-acetylspermidine and by the presence of inhibitors. The enzyme is inhibited by various compounds, including hydrazine, semicarbazide, and aminoguanidine.'
"
| Protein | Definition | Taxonomy |
|---|---|---|
| Peroxisomal N(1)-acetyl-spermine/spermidine oxidase | A peroxisomal N(1)-acetyl-spermine/spermidine oxidase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6QHF9] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| n(1)-acetylspermidine | N(1)-acetylspermidine : An acetylspermidine having the acetyl group at the N1-position. | acetylspermidine | Escherichia coli metabolite; metabolite |
| n-acetylputrescine | N-acetylputrescine : An N-monoacetylalkane-alpha,omega-diamine that is the N-monoacetyl derivative of putrescine. | N-monoacetylalkane-alpha,omega-diamine; N-substituted putrescine | metabolite; mouse metabolite |
| n(8)-acetylspermidine | N(8)-acetylspermidine : An acetylspermidine that is 1,8-diamino-4-azaoctane in which one of the hydrogens of the amino group attached to C-8 is replaced by an acetyl group. | acetylspermidine | Escherichia coli metabolite; human metabolite |
| 7-(n-(3-aminopropyl)amino)heptan-2-one | 7-(N-(3-aminopropyl)amino)heptan-2-one: inhibits N(8)-acetylspermidine deacetylation in mice | ||
| n-acetyl-1,6-diaminohexane | |||
| chlorhexidine | chlorhexidine : A bisbiguanide compound with a structure consisting of two (p-chlorophenyl)guanide units linked by a hexamethylene bridge. Chlorhexidine: A disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque. | biguanides; monochlorobenzenes | antibacterial agent; antiinfective agent |