Page last updated: 2024-12-10

15,23-dihydrosirohydrochlorin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

**15,23-Dihydrosirohydrochlorin** is a tetrapyrrole molecule that is a key intermediate in the biosynthesis of both heme and chlorophyll. It is a reduced form of sirohydrochlorin, which is itself a reduced form of protoporphyrin IX.

Here's why it's important for research:

* **Understanding Biosynthesis:** Studying 15,23-dihydrosirohydrochlorin helps researchers understand the complex biochemical pathways involved in the synthesis of heme and chlorophyll. These pathways are crucial for a wide range of biological processes, including oxygen transport, photosynthesis, and cellular respiration.
* **Developing New Drugs:** Understanding the mechanisms of heme and chlorophyll biosynthesis can lead to the development of new drugs targeting these pathways. For example, drugs that inhibit the synthesis of heme could be used to treat certain types of cancer.
* **Environmental Research:** Chlorophyll is essential for photosynthesis, the process by which plants convert sunlight into energy. Studying the biosynthesis of chlorophyll can help researchers understand the impact of environmental factors on plant growth and development.
* **Understanding Photosynthesis:** 15,23-dihydrosirohydrochlorin is a precursor to chlorophyll, which is essential for photosynthesis. Researchers can study its role in the assembly of the chlorophyll molecule and its function in light harvesting.

**In summary, 15,23-dihydrosirohydrochlorin is a key intermediate in the biosynthesis of heme and chlorophyll, making it a crucial molecule for understanding a wide range of biological processes and for developing new drugs and environmental research applications.**

15,23-dihydrosirohydrochlorin: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

precorrin-2 : The second intermediate in the biosynthesis of vitamin B12 from uroporphyrinogen III, in which methyl groups have been introduced at positions 2 and 7 of the tetrapyrrole framework. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID5280516
CHEBI ID50602
MeSH IDM0174592

Synonyms (11)

Synonym
precorrin 2
C02463
precorrin-2
82542-92-5
DIHYDROSIROHYDROCHLORIN ,
CHEBI:50602
15,23-dihydrosirohydrochlorin
3,3',3'',3'''-[(7s,8s,12s,13s)-3,8,13,17-tetrakis(carboxymethyl)-8,13-dimethyl-7,8,12,13,20,24-hexahydroporphyrin-2,7,12,18-tetrayl]tetrapropanoic acid
3-[(1z,2s,3s,4z,15z,17s,18s)-8,12,17-tris(2-carboxyethyl)-3,7,13,18-tetrakis(carboxymethyl)-3,18-dimethyl-2,10,17,21,22,23-hexahydroporphyrin-2-yl]propanoic acid
3,3',3'',3'''-[(7s,8s,12s,13s)-3,8,13,17-tetrakis(carboxymethyl)-8,13-dimethyl-7,8,12,13,20,24-hexahydroporphyrin-2,7,1
2,18-tetrayl]tetrapropanoic acid
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (18)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's8 (44.44)18.2507
2000's7 (38.89)29.6817
2010's2 (11.11)24.3611
2020's1 (5.56)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.38

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.38 (24.57)
Research Supply Index2.94 (2.92)
Research Growth Index4.33 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.38)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other18 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]