**15,23-Dihydrosirohydrochlorin** is a tetrapyrrole molecule that is a key intermediate in the biosynthesis of both heme and chlorophyll. It is a reduced form of sirohydrochlorin, which is itself a reduced form of protoporphyrin IX.
Here's why it's important for research:
* **Understanding Biosynthesis:** Studying 15,23-dihydrosirohydrochlorin helps researchers understand the complex biochemical pathways involved in the synthesis of heme and chlorophyll. These pathways are crucial for a wide range of biological processes, including oxygen transport, photosynthesis, and cellular respiration.
* **Developing New Drugs:** Understanding the mechanisms of heme and chlorophyll biosynthesis can lead to the development of new drugs targeting these pathways. For example, drugs that inhibit the synthesis of heme could be used to treat certain types of cancer.
* **Environmental Research:** Chlorophyll is essential for photosynthesis, the process by which plants convert sunlight into energy. Studying the biosynthesis of chlorophyll can help researchers understand the impact of environmental factors on plant growth and development.
* **Understanding Photosynthesis:** 15,23-dihydrosirohydrochlorin is a precursor to chlorophyll, which is essential for photosynthesis. Researchers can study its role in the assembly of the chlorophyll molecule and its function in light harvesting.
**In summary, 15,23-dihydrosirohydrochlorin is a key intermediate in the biosynthesis of heme and chlorophyll, making it a crucial molecule for understanding a wide range of biological processes and for developing new drugs and environmental research applications.**
15,23-dihydrosirohydrochlorin: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
precorrin-2 : The second intermediate in the biosynthesis of vitamin B12 from uroporphyrinogen III, in which methyl groups have been introduced at positions 2 and 7 of the tetrapyrrole framework. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
ID Source | ID |
---|---|
PubMed CID | 5280516 |
CHEBI ID | 50602 |
MeSH ID | M0174592 |
Synonym |
---|
precorrin 2 |
C02463 |
precorrin-2 |
82542-92-5 |
DIHYDROSIROHYDROCHLORIN , |
CHEBI:50602 |
15,23-dihydrosirohydrochlorin |
3,3',3'',3'''-[(7s,8s,12s,13s)-3,8,13,17-tetrakis(carboxymethyl)-8,13-dimethyl-7,8,12,13,20,24-hexahydroporphyrin-2,7,12,18-tetrayl]tetrapropanoic acid |
3-[(1z,2s,3s,4z,15z,17s,18s)-8,12,17-tris(2-carboxyethyl)-3,7,13,18-tetrakis(carboxymethyl)-3,18-dimethyl-2,10,17,21,22,23-hexahydroporphyrin-2-yl]propanoic acid |
3,3',3'',3'''-[(7s,8s,12s,13s)-3,8,13,17-tetrakis(carboxymethyl)-8,13-dimethyl-7,8,12,13,20,24-hexahydroporphyrin-2,7,1 |
2,18-tetrayl]tetrapropanoic acid |
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 8 (44.44) | 18.2507 |
2000's | 7 (38.89) | 29.6817 |
2010's | 2 (11.11) | 24.3611 |
2020's | 1 (5.56) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (11.38) All Compounds (24.57) |
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 0 (0.00%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 18 (100.00%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |