Compounds > neuropeptide y (24-36) amide, n-acetyl-(leu(28,31))-
Page last updated: 2024-11-12

neuropeptide y (24-36) amide, n-acetyl-(leu(28,31))-

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Description

neuropeptide Y (24-36) amide, N-acetyl-(Leu(28,31))-: a presynaptic (Y2) receptor-specific neuropeptide Y analog [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID16131052
MeSH IDM0232635

Synonyms (10)

Synonym
ac(leu-28,31)npy(24-36)amide
n-acetyl(leu(28),leu(31))npy(24-36)-amide
n-acetyl-l-leucyl-l-arginyl-l-histidyl-l-tyrosyl-l-leucyl-l-asparaginyl-l-leucyl-l-leucyl-l-threonyl-l-arginyl-l-glutaminyl-l-arginyl-l-tyrosinamide
l-tyrosinamide, n-acetyl-l-leucyl-l-arginyl-l-histidyl-l-tyrosyl-l-leucyl-l-asparaginyl-l-leucyl-l-leucyl-l-threonyl-l-arginyl-l-glutaminyl-l-arginyl-
n-acetyl(leu-28,leu-31)npy(24-36)-amide
neuropeptide y (24-36) amide, n-acetyl-(leu(28,31))-
155709-24-3
NCGC00167292-01
DTXSID50165956
ac-leu-arg-his-tyr-leu-asn-leu-leu-thr-arg-gln-arg-tyr-nh2
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (3)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Neuropeptide Y receptor type 1Homo sapiens (human)Ki0.21000.00010.22952.3150AID1063833; AID299147
Neuropeptide Y receptor type 2Homo sapiens (human)IC50 (µMol)0.00390.00020.74804.4000AID1226438
Neuropeptide Y receptor type 2Homo sapiens (human)Ki0.00500.00010.00260.0050AID1063832; AID299146
Neuropeptide Y receptor type 5Homo sapiens (human)Ki1.00000.00151.66775.0000AID1063831; AID299148
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Neuropeptide Y receptor type 2Homo sapiens (human)EC50 (µMol)0.00600.00600.00600.0060AID1063834; AID299144
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (23)

Processvia Protein(s)Taxonomy
outflow tract morphogenesisNeuropeptide Y receptor type 1Homo sapiens (human)
glucose metabolic processNeuropeptide Y receptor type 1Homo sapiens (human)
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerNeuropeptide Y receptor type 1Homo sapiens (human)
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathwayNeuropeptide Y receptor type 1Homo sapiens (human)
neuropeptide signaling pathwayNeuropeptide Y receptor type 1Homo sapiens (human)
locomotory behaviorNeuropeptide Y receptor type 1Homo sapiens (human)
feeding behaviorNeuropeptide Y receptor type 1Homo sapiens (human)
regulation of blood pressureNeuropeptide Y receptor type 1Homo sapiens (human)
sensory perception of painNeuropeptide Y receptor type 1Homo sapiens (human)
regulation of multicellular organism growthNeuropeptide Y receptor type 1Homo sapiens (human)
outflow tract morphogenesisNeuropeptide Y receptor type 2Homo sapiens (human)
cardiac left ventricle morphogenesisNeuropeptide Y receptor type 2Homo sapiens (human)
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathwayNeuropeptide Y receptor type 2Homo sapiens (human)
neuropeptide signaling pathwayNeuropeptide Y receptor type 2Homo sapiens (human)
locomotory behaviorNeuropeptide Y receptor type 2Homo sapiens (human)
positive regulation of acute inflammatory responseNeuropeptide Y receptor type 5Homo sapiens (human)
negative regulation of acute inflammatory response to antigenic stimulusNeuropeptide Y receptor type 5Homo sapiens (human)
outflow tract morphogenesisNeuropeptide Y receptor type 5Homo sapiens (human)
cardiac left ventricle morphogenesisNeuropeptide Y receptor type 5Homo sapiens (human)
neuropeptide signaling pathwayNeuropeptide Y receptor type 5Homo sapiens (human)
negative regulation of glutamate secretionNeuropeptide Y receptor type 5Homo sapiens (human)
negative regulation of synaptic transmission, GABAergicNeuropeptide Y receptor type 5Homo sapiens (human)
eating behaviorNeuropeptide Y receptor type 5Homo sapiens (human)
negative regulation of apoptotic processNeuropeptide Y receptor type 5Homo sapiens (human)
positive regulation of smooth muscle cell proliferationNeuropeptide Y receptor type 5Homo sapiens (human)
generation of ovulation cycle rhythmNeuropeptide Y receptor type 5Homo sapiens (human)
positive regulation of ERK1 and ERK2 cascadeNeuropeptide Y receptor type 5Homo sapiens (human)
synaptic signaling via neuropeptideNeuropeptide Y receptor type 5Homo sapiens (human)
chemical synaptic transmissionNeuropeptide Y receptor type 5Homo sapiens (human)
G protein-coupled receptor signaling pathwayNeuropeptide Y receptor type 5Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (8)

Processvia Protein(s)Taxonomy
peptide YY receptor activityNeuropeptide Y receptor type 1Homo sapiens (human)
pancreatic polypeptide receptor activityNeuropeptide Y receptor type 1Homo sapiens (human)
neuropeptide Y receptor activityNeuropeptide Y receptor type 1Homo sapiens (human)
protein bindingNeuropeptide Y receptor type 1Homo sapiens (human)
neuropeptide receptor activityNeuropeptide Y receptor type 1Homo sapiens (human)
neuropeptide bindingNeuropeptide Y receptor type 1Homo sapiens (human)
peptide YY receptor activityNeuropeptide Y receptor type 2Homo sapiens (human)
neuropeptide Y receptor activityNeuropeptide Y receptor type 2Homo sapiens (human)
calcium channel regulator activityNeuropeptide Y receptor type 2Homo sapiens (human)
protein bindingNeuropeptide Y receptor type 2Homo sapiens (human)
signaling receptor activityNeuropeptide Y receptor type 2Homo sapiens (human)
neuropeptide Y receptor activityNeuropeptide Y receptor type 5Homo sapiens (human)
pancreatic polypeptide receptor activityNeuropeptide Y receptor type 5Homo sapiens (human)
peptide YY receptor activityNeuropeptide Y receptor type 5Homo sapiens (human)
neuropeptide bindingNeuropeptide Y receptor type 5Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (6)

Processvia Protein(s)Taxonomy
plasma membraneNeuropeptide Y receptor type 1Homo sapiens (human)
plasma membraneNeuropeptide Y receptor type 1Homo sapiens (human)
neuron projectionNeuropeptide Y receptor type 1Homo sapiens (human)
plasma membraneNeuropeptide Y receptor type 2Homo sapiens (human)
ciliumNeuropeptide Y receptor type 2Homo sapiens (human)
non-motile ciliumNeuropeptide Y receptor type 2Homo sapiens (human)
plasma membraneNeuropeptide Y receptor type 5Homo sapiens (human)
presynapseNeuropeptide Y receptor type 5Homo sapiens (human)
GABA-ergic synapseNeuropeptide Y receptor type 5Homo sapiens (human)
plasma membraneNeuropeptide Y receptor type 5Homo sapiens (human)
neuron projectionNeuropeptide Y receptor type 5Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (16)

Assay IDTitleYearJournalArticle
AID1226432Effect on body weight in diet-induced obese C57BL/6JRj mouse at 50 to 250 nM/kg, ip2015Journal of medicinal chemistry, May-28, Volume: 58, Issue:10
Rational design of dual peptides targeting ghrelin and Y2 receptors to regulate food intake and body weight.
AID299144Agonist activity at human NPY2 receptor in KAN-TS cells by [35S]GTP-gamma-S binding assay2007Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
A long-acting selective neuropeptide Y2 receptor PEGylated peptide agonist reduces food intake in mice.
AID1063832Binding affinity to NPYY2 receptor (unknown origin)2014Bioorganic & medicinal chemistry letters, Jan-15, Volume: 24, Issue:2
Ligands of the neuropeptide Y Y2 receptor.
AID1226431Effect on food intake in diet-induced obese C57BL/6JRj mouse at 50 to 250 nM/kg, ip2015Journal of medicinal chemistry, May-28, Volume: 58, Issue:10
Rational design of dual peptides targeting ghrelin and Y2 receptors to regulate food intake and body weight.
AID299148Displacement of [125I]PYY from human NPY5 receptor in HEK293 cells2007Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
A long-acting selective neuropeptide Y2 receptor PEGylated peptide agonist reduces food intake in mice.
AID1226430Effect on body weight in diet-induced obese C57BL/6JRj mouse at 500 nM/kg, sc2015Journal of medicinal chemistry, May-28, Volume: 58, Issue:10
Rational design of dual peptides targeting ghrelin and Y2 receptors to regulate food intake and body weight.
AID299145Agonist activity at human NPY2 receptor in KAN-TS cells at 1 uM by [35S]GTP-gamma-S binding assay2007Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
A long-acting selective neuropeptide Y2 receptor PEGylated peptide agonist reduces food intake in mice.
AID299149Reduction of food intake in C57BL/6 mouse at 10 mg/kg, sc after 1 to 24 hrs2007Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
A long-acting selective neuropeptide Y2 receptor PEGylated peptide agonist reduces food intake in mice.
AID1063831Binding affinity to NPYY5 receptor (unknown origin)2014Bioorganic & medicinal chemistry letters, Jan-15, Volume: 24, Issue:2
Ligands of the neuropeptide Y Y2 receptor.
AID299147Displacement of [125I]PYY from human NPY1 receptor in SK-N-MC cells2007Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
A long-acting selective neuropeptide Y2 receptor PEGylated peptide agonist reduces food intake in mice.
AID1226429Effect on food intake in diet-induced obese C57BL/6JRj mouse at 500 nM/kg, sc2015Journal of medicinal chemistry, May-28, Volume: 58, Issue:10
Rational design of dual peptides targeting ghrelin and Y2 receptors to regulate food intake and body weight.
AID299146Displacement of [125I]PYY from human NPY2 receptor in KAN-TS cells by SPA assay2007Bioorganic & medicinal chemistry letters, Apr-01, Volume: 17, Issue:7
A long-acting selective neuropeptide Y2 receptor PEGylated peptide agonist reduces food intake in mice.
AID1063833Binding affinity to NPYY1 receptor (unknown origin)2014Bioorganic & medicinal chemistry letters, Jan-15, Volume: 24, Issue:2
Ligands of the neuropeptide Y Y2 receptor.
AID1226436Decrease in food intake in diet-induced obese C57BL/6JRj mouse at 0.25 nM/h, sc administered via osmotic minipumps daily for 14 days2015Journal of medicinal chemistry, May-28, Volume: 58, Issue:10
Rational design of dual peptides targeting ghrelin and Y2 receptors to regulate food intake and body weight.
AID1063834Agonist activity at NPYY2 receptor (unknown origin)2014Bioorganic & medicinal chemistry letters, Jan-15, Volume: 24, Issue:2
Ligands of the neuropeptide Y Y2 receptor.
AID1226438Agonist activity at neuropeptide Y Y2 receptor in human SMS-KAN cells2015Journal of medicinal chemistry, May-28, Volume: 58, Issue:10
Rational design of dual peptides targeting ghrelin and Y2 receptors to regulate food intake and body weight.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's3 (50.00)18.2507
2000's1 (16.67)29.6817
2010's2 (33.33)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.56

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.56 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index4.64 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.56)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (14.29%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (85.71%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
atropine
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate : A tropane alkaloid that is (1R,5)-8-methyl-8-azabicyclo[3.2.1]octane substituted by a (3-hydroxy-2-phenylpropanoyl)oxy group at position 3.		1.9910
capsaicin
ALGRX-4975: an injectable capsaicin (TRPV1 receptor agonist) formulation for longlasting pain relief. capsaicinoid : A family of aromatic fatty amides produced as secondary metabolites by chilli peppers.		1.9910capsaicinoidnon-narcotic analgesic;
TRPV1 agonist;
voltage-gated sodium channel blocker
N-(4-ethoxyphenyl)-4-[hydroxy(diphenyl)methyl]-1-piperidinecarbothioamide
[no description available]		3.1910diarylmethane
2-(2-methoxyphenyl)-N-[4-[5-(3-methoxyphenyl)-1,2,4-oxadiazol-3-yl]phenyl]acetamide
[no description available]		3.1910oxadiazole;
ring assembly
3,5-dimethyl-4-[(4-methylphenyl)sulfonyl-phenylmethyl]isoxazole
[no description available]		3.1910sulfonic acid derivative
jnj-5207787
N-(1-Acetyl-2,3-dihydro-1H-indol-6-yl)-3-(3-cyano-phenyl)-N-(1-(2-cyclopentyl-ethyl)-piperidin-4yl)acrylamide: structure in first source		3.1910
neuropeptide y
Neuropeptide Y: A 36-amino acid peptide present in many organs and in many sympathetic noradrenergic neurons. It has vasoconstrictor and natriuretic activity and regulates local blood flow, glandular secretion, and smooth muscle activity. The peptide also stimulates feeding and drinking behavior and influences secretion of pituitary hormones.		2.6830
jnj-31020028
[no description available]		3.1910
neuropeptide y, leu(31)-pro(34)-
neuropeptide Y, Leu(31)-Pro(34)-: specific Y1 receptor agonist		1.9810
peptide yy
Peptide YY: A 36-amino acid peptide produced by the L cells of the distal small intestine and colon. Peptide YY inhibits gastric and pancreatic secretion.. peptide YY : A 36-membered human gut polypeptide consisting of Tyr, Pro, Ile, Lys, Pro, Glu, Ala, Pro, Gly, Glu, Asp, Ala, Ser, Pro, Glu, Glu, Leu, Asn, Arg, Tyr, Tyr, Ala, Ser, Leu, Arg, His, Tyr, Leu, Asn, Leu, Val, Thr, Arg, Gln, Arg and Tyr-NH2 residues joined in sequence.		1.9810
ConditionIndicatedRelationship StrengthStudiesTrials
Body Weight
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.		02.1110
Muscle Contraction
A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.		01.9810
Anesthesia
A state characterized by loss of feeling or sensation. This depression of nerve function is usually the result of pharmacologic action and is induced to allow performance of surgery or other painful procedures.		01.9910