Page last updated: 2024-08-07 21:28:51

Peroxiredoxin-1

A peroxiredoxin-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q06830]

Synonyms

EC 1.11.1.24;
Natural killer cell-enhancing factor A;
NKEF-A;
Proliferation-associated gene protein;
PAG;
Thioredoxin peroxidase 2;
Thioredoxin-dependent peroxide reductase 2;
Thioredoxin-dependent peroxiredoxin 1

Research

Bioassay Publications (1)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (100.00)24.3611
2020's0 (0.00)2.80

Compounds (2)

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
piericidin aHomo sapiens (human)Kd2.610011
glucopiericidin aHomo sapiens (human)Kd1.830011

Enables

This protein enables 6 target(s):

TargetCategoryDefinition
RNA bindingmolecular functionBinding to an RNA molecule or a portion thereof. [GOC:jl, GOC:mah]
peroxidase activitymolecular functionCatalysis of the reaction: a donor + a peroxide = an oxidized donor + 2 H2O. [GOC:curators]
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
thioredoxin peroxidase activitymolecular functionCatalysis of the reaction: [thioredoxin]-dithiol + hydrogen peroxide = [thioredoxin]-disulfide + H2O. [RHEA:63528]
identical protein bindingmolecular functionBinding to an identical protein or proteins. [GOC:jl]
cadherin bindingmolecular functionBinding to cadherin, a type I membrane protein involved in cell adhesion. [GOC:bf]

Located In

This protein is located in 6 target(s):

TargetCategoryDefinition
extracellular spacecellular componentThat part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684]
nucleuscellular componentA membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
cytoplasmcellular componentThe contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
cytosolcellular componentThe part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
melanosomecellular componentA tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells. [GOC:jl, PMID:11584301]
extracellular exosomecellular componentA vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]

Active In

This protein is active in 1 target(s):

TargetCategoryDefinition
cytosolcellular componentThe part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

Involved In

This protein is involved in 15 target(s):

TargetCategoryDefinition
skeletal system developmentbiological processThe process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton). [GOC:dph, GOC:jid, GOC:tb]
canonical NF-kappaB signal transductionbiological processAn intracellular signaling cassette characterized by the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB, also known as the canonical NF-kappaB signaling cascade. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. The canonical NF-kappaB pathway is mainly stimulated by proinflammatory cytokines such as IL-1beta, tumor necrosis factor (TNF)-alpha, antigen ligands, and toll-like receptors (TLRs). [GOC:bf, PMID:12773372, PMID:34659217]
cell population proliferationbiological processThe multiplication or reproduction of cells, resulting in the expansion of a cell population. [GOC:mah, GOC:mb]
natural killer cell activationbiological processThe change in morphology and behavior of a natural killer cell in response to a cytokine, chemokine, cellular ligand, or soluble factor. [GOC:mgi_curators, ISBN:0781735149]
regulation of stress-activated MAPK cascadebiological processAny process that modulates the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade. [GOC:mah]
erythrocyte homeostasisbiological processAny process of regulating the production and elimination of erythrocytes within an organism. [GOC:add, PMID:10694114, PMID:14754397]
natural killer cell mediated cytotoxicitybiological processThe directed killing of a target cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors. [GOC:add, GOC:pr]
hydrogen peroxide catabolic processbiological processThe chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2). [GOC:jl]
fibroblast proliferationbiological processThe multiplication or reproduction of fibroblast cells, resulting in the expansion of the fibroblast population. [GOC:jid]
regulation of non-canonical NF-kappaB signal transductionbiological processAny process that modulates the frequency, rate or extent of the non-canonical NF-kappaB signaling cascade. [GOC:TermGenie]
removal of superoxide radicalsbiological processAny process, acting at the cellular level, involved in removing superoxide radicals (O2-) from a cell or organism, e.g. by conversion to dioxygen (O2) and hydrogen peroxide (H2O2). [GOC:jl]
cell redox homeostasisbiological processAny process that maintains the redox environment of a cell or compartment within a cell. [GOC:ai, GOC:dph, GOC:tb]
leukocyte activationbiological processA change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor. [GOC:add]
response to oxidative stressbiological processAny process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. [GOC:jl, PMID:12115731]
cellular response to stressbiological processAny process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). [GOC:mah]