10,11-dihydroxy-n-allylnoraporphine

Description

10,11-dihydroxy-N-allylnoraporphine, often abbreviated as **DHAN**, is a synthetic derivative of the alkaloid aporphine. It's important for research because of its potential therapeutic applications in treating neurological disorders.

Here's a breakdown of its importance:

**What it is:**

* **Aporphine derivative:** DHAN is structurally similar to naturally occurring aporphine alkaloids, which are found in various plants.
* **Synthetic:** DHAN is not found naturally and must be synthesized in a lab.
* **N-allyl group:** This structural modification differentiates DHAN from other aporphine derivatives.

**Why it's important for research:**

* **Neuroprotective effects:** Studies have shown that DHAN exhibits neuroprotective properties, potentially protecting neurons from damage caused by oxidative stress, inflammation, and other factors that contribute to neurodegenerative diseases.
* **Antioxidant activity:** DHAN possesses strong antioxidant activity, which may be beneficial in combating oxidative stress, a major contributing factor to aging and disease.
* **Possible therapeutic potential for neurological disorders:** Due to its neuroprotective and antioxidant properties, DHAN is being investigated as a potential treatment for various neurological conditions, including Alzheimer's disease, Parkinson's disease, and stroke.
* **Potential for drug development:** The research on DHAN could lead to the development of new and effective therapies for neurological disorders.

**Current research focus:**

* Understanding the exact mechanisms of DHAN's neuroprotective and antioxidant effects.
* Investigating its efficacy and safety in preclinical models of neurological disorders.
* Developing novel drug delivery systems for DHAN to enhance its bioavailability and therapeutic efficacy.

While research on DHAN is promising, it's still in its early stages. More research is needed to fully understand its potential and ensure its safety and efficacy in humans.

10,11-dihydroxy-N-allylnoraporphine: RN refers to (R)-isomer; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]