Compounds > 2-amino-5-nitropyridine
Page last updated: 2024-11-06

2-amino-5-nitropyridine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

2-Amino-5-nitropyridine is a yellow crystalline solid that has been studied for its potential applications in various fields. It is synthesized through the nitration of 2-aminopyridine using a mixture of nitric acid and sulfuric acid. 2-Amino-5-nitropyridine exhibits interesting properties, including its ability to act as a chelating agent for metal ions, its potential as a building block for pharmaceuticals, and its potential use in organic electronics. Its ability to coordinate with metal ions makes it relevant for the development of catalysts and sensors. The presence of both amino and nitro groups makes it a versatile starting material for the synthesis of various pharmaceuticals, including anti-cancer agents and anti-inflammatory drugs. Research is ongoing to explore its potential applications in organic electronics due to its electronic properties and potential for use in organic light-emitting diodes (OLEDs). The compound's unique structure and its potential for diverse applications contribute to its ongoing scientific interest.'

Cross-References

ID SourceID
PubMed CID77888
CHEMBL ID4447423
SCHEMBL ID116229
MeSH IDM0513105

Synonyms (52)

Synonym
2-amino-5-nitro pyridine
ai3-19226
einecs 224-145-6
5-nitropyrimidin-2-ylamine
nsc 23774
5-nitro-2-aminopyridine
4214-76-0
pyridine, 2-amino-5-nitro-
2-amino-5-nitropyridine ,
nsc23774
2-pyridinamine, 5-nitro-
nsc-23774
5-nitro-2-pyridinamine
AH-034/32462004
inchi=1/c5h5n3o2/c6-5-2-1-4(3-7-5)8(9)10/h1-3h,(h2,6,7
2-amino-5-nitropyridine, 97%
AC-4393
A0794
67476-67-9
FT-0653514
STK801376
5-nitropyridin-2-amine
AKOS000120227
A9038
A6894
BBL009980
BP-13039
FT-0611185
AM20100116
SCHEMBL116229
mfcd00006325
SY005081
PS-3482
5-nitro-pyridin-2-ylamine
5-nitropyridine-2-amine
2-amino-5-nitro-pyridine
DTXSID6063357
5-nitro-2-pyridinamine #
Q-103400
STR05721
GEO-00192
2-amino-5-nitropyridine, technical, >=95.0% (nt)
CHEMBL4447423 ,
CS-W016479
BCP23076
EN300-21336
SB12750
FD9107
A847721
bdbm50523947
SB53251
Z104495402
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Replicase polyprotein 1abBetacoronavirus England 1IC50 (µMol)137.00000.00403.43889.5100AID1594515
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (1)

Assay IDTitleYearJournalArticle
AID1594515Inhibition of MERS-CoV papain-like protease using Z-Arg-Leu-Arg-Gly-Gly-AMC as substrate preincubated for 5 mins followed by substrate addition and measured for 10 mins by fluorescence assay2019Bioorganic & medicinal chemistry, 05-15, Volume: 27, Issue:10
Identification and design of novel small molecule inhibitors against MERS-CoV papain-like protease via high-throughput screening and molecular modeling.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (40.00)29.6817
2010's3 (60.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 23.42

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index23.42 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.63 (4.65)
Search Engine Demand Index21.17 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (23.42)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
sulfasalazine
Sulfasalazine: A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see MESALAMINE) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907). sulfasalazine : An azobenzene consisting of diphenyldiazene having a carboxy substituent at the 4-position, a hydroxy substituent at the 3-position and a 2-pyridylaminosulphonyl substituent at the 4'-position.		2.2110
trifluoroacetic acid
Trifluoroacetic Acid: A very strong halogenated derivative of acetic acid. It is used in acid catalyzed reactions, especially those where an ester is cleaved in peptide synthesis.. trifluoroacetic acid : A monocarboxylic acid that is the trifluoro derivative of acetic acid.		2.110fluoroalkanoic acidhuman xenobiotic metabolite;
NMR chemical shift reference compound;
reagent
protocatechualdehyde
protocatechualdehyde: found in wheat grains, wheat seedlings, & other plants; RN given refers to parent cpd; see also rancinamycins; structure		2.2110dihydroxybenzaldehyde
alpha-aminopyridine
alpha-aminopyridine: RN given refers to parent cpd; structure in Merck Index, 9th ed, #485. aminopyridine : Compounds containing a pyridine skeleton substituted by one or more amine groups.		2.9840
4-chloro-7-nitrobenzofurazan
4-Chloro-7-nitrobenzofurazan: A benzofuran derivative used as a protein reagent since the terminal N-NBD-protein conjugate possesses interesting fluorescence and spectral properties. It has also been used as a covalent inhibitor of both beef heart mitochondrial ATPase and bacterial ATPase.. 4-chloro-7-nitrobenzofurazan : A benzoxadiazole that is 2,1,3-benzoxadiazole which is substituted at position 4 by chlorine and at position 7 by a nitro group.		2.2110benzoxadiazole;
C-nitro compound;
organochlorine compound		EC 1.4.3.4 (monoamine oxidase) inhibitor;
EC 3.6.1.3 (adenosinetriphosphatase) inhibitor;
fluorescent probe;
fluorochrome
1-(4-nitrophenyl)piperazine
1-(4-nitrophenyl)piperazine: structure in first source		2.2110
2-methyl-3-nitro-4-methoxymethyl-5-cyano-6-oxypyridine
2-methyl-3-nitro-4-methoxymethyl-5-cyano-6-oxypyridine: structure in first source		2.0310
4-nitrocatechol
4-nitrocatechol : A member of the class of catechols that is benzene-1,2-diol substituted by a nitro group at position 4.It is the by-product of the hydroxylation of p-nitrophenol.		2.2110C-nitro compound;
catechols		human xenobiotic metabolite;
lipoxygenase inhibitor
ConditionIndicatedRelationship StrengthStudiesTrials